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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 641 to 650 of 748.

N-Aryl-2-iso-butylmercaptoacetamides: the discovery of highly potent and selective inhibitors of Pseudomonas aeruginosa virulence factor LasB and Clostridium histolyticum virulence factor ColH

Publication
Voos K, Yahiaoui S, Konstantinovic J, Schönauer E, Alhayek A, Sikandar A, Si Chaib K, Ramspoth T, Rox K, Haupenthal J, Köhnke J, Brandstetter H, Ducho C, Hirsch A (2022)
ChemRxiv, 10.26434/chemrxiv-2022-fjrqr

Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin‐Wound Infections

Publication
Alhayek A, Khan E, Schönauer E, Däinghaus T, Shafiei R, Voos K, Han M, Ducho C, Posselt G, Wessler S, Brandstetter H, Haupenthal J, del Campo A, Hirsch A (2022)
Adv. Therap., 10.1002/adtp.202100222

Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor

Publication
Drost M, Diamanti E, Fuhrmann K, Goes A, Shams A, Haupenthal J, Koch M, Hirsch A, Fuhrmann G (2022)
Pharmaceutics, 14, 1, 10.3390/pharmaceutics14010004

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors

Publication
Wimmer S, Hoff K, Martin B, Grewer M, Denni L, Lascorz Massanet R, Raimondi M, Bülbül E, Melesina J, Hotop S, Haupenthal J, Rohde H, Heisig P, Hirsch A, Brönstrup M, Sippl W, Holl R (2022)
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505

New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities

Publication
Aydinli S, Bulut E, Deniz N, Sayil C, Komarovska-Porokhnyavets O, Lubenets V, Zvarych V, Stasevych M, Nesterkina M, Kravchenko I (2022)
Chemistry & Biodiversity, 19, 7, 10.1002/cbdv.202100931, 35674435

Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

Publication
Alhayek A, Abdelsamie A, Schönauer E, Camberlein V, Hutterer E, Posselt G, Serwanja J, Blöchl C, Huber C, Haupenthal J, Brandstetter H, Wessler S, Hirsch A (2022)
Journal of medicinal chemistry, 65, 19, 12933-12955, 10.1021/acs.jmedchem.2c00785, 36154055

(1 R ,2 S ,5 R )-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity

Publication
Nesterkina M, Musatov V, Honcharova O, Kravchenko I (2022)
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189

An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay

Publication
Bousis S, Winkler S, Haupenthal J, Fulco F, Diamanti E, Hirsch A (2022)
International journal of molecular sciences, 23, 5, 10.3390/ijms23052637, 35269783

First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Publication
Gierse R, Oerlemans R, Reddem E, Gawriljuk V, Alhayek A, Baitinger D, Jakobi H, Laber B, Lange G, Hirsch A, Groves M (2022)
Sci. Rep., 12, 1, 10.1038/s41598-022-11205-9, 35508530

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Publication
Camberlein V, Fléau C, Sierocki P, Li L, Gealageas R, Bosc D, Guillaume V, Warenghem S, Leroux F, Rosell M, Cheng K, Medve L, Prigent M, Decanter M, Piveteau C, Biela A, Eveque M, Dumont J, Mpakali A, Giastas P, Herledan A, Couturier C, Haupenthal J, Lesire L, Hirsch A, Deprez B, Stratikos E, Bouvier M, Deprez-Poulain R (2022)
Angew. Chemie, 134, 39, 10.1002/ange.202203560