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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 631 to 640 of 744.

Between two worlds: a comparative study on in vitro and in silico inhibition of trypsin and matriptase by redox-stable SFTI-1 variants at near physiological pH

Publication
Avrutina O, Fittler H, Glotzbach B, Kolmar H, Empting M (2012)
Org. Biomol. Chem., 10, 38, 7753-62, 10.1039/c2ob26162f, 22903577

Biodynamers: self-organization-driven formation of doubly dynamic proteoids

Publication
Hirsch A, Buhler E, Lehn J (2012)
Journal of the American Chemical Society, 134, 9, 4177-83, 10.1021/ja2099134, 22300496

Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations

Publication
Tischler M, Nasu D, Empting M, Schmelz S, Heinz D, Rottmann P, Kolmar H, Buntkowsky G, Tietze D, Avrutina O (2012)
Angewandte Chemie (International ed. in English), 51, 15, 3708-12, 10.1002/anie.201108983, 22374650

Total synthesis of (-)-doliculide, structure-activity relationship studies and its binding to F-actin

Publication
Matcha K, Madduri A, Roy S, Ziegler S, Waldmann H, Hirsch A, Minnaard A (2012)
ChemBioChem, 13, 17, 2537-48, 10.1002/cbic.201200512, 23129522

'Triazole bridge': disulfide-bond replacement by ruthenium-catalyzed formation of 1,5-disubstituted 1,2,3-triazoles

Publication
Empting M, Avrutina O, Meusinger R, Fabritz S, Reinwarth M, Biesalski M, Voigt S, Buntkowsky G, Kolmar H (2011)
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910

Towards click bioconjugations on cube-octameric silsesquioxane scaffolds

Publication
Fabritz S, Heyl D, Bagutski V, Empting M, Rikowski E, Frauendorf H, Balog I, Fessner W, Schneider J, Avrutina O, Kolmar H (2010)
Org. Biomol. Chem., 8, 9, 2212-8, 10.1039/b923393h, 20401398

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Publication
Bravo P, Diamanti E, Hamed M, Bizzarri L, Wiedemar N, Passecker A, Brancucci N, Albisetti A, Gumpp C, Illarionov B, Fischer M, Witschel M, Schehl T, Hahne H, Mäser P, Rottmann M, Hirsch A (2025)
Angew. Chem. Int. Ed., 10.1002/anie.202514085, 41116297

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity

Publication
Mielniczuk S, Hoff K, Baselious F, Li Y, Haupenthal J, Kany A, Riedner M, Rohde H, Rox K, Hirsch A, Krimm I, Sippl W, Holl R (2024)
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295

Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity

Publication
Al-Saad O, Gabr M, Darwish S, Rullo M, Pisani L, Miniero D, Liuzzi G, Kany A, Hirsch A, Abadi A, Engel M, Catto M, Abdel-Halim M (2024)
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266

Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes

Publication
Chen X, Zhao H, Wang C, Hamed M, Shang Q, Yang Y, Diao X, Sun X, Hu W, Jiang X, Zhang Y, Hirsch A, Wu D, Zhuang J (2024)
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721