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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 631 to 640 of 760.

Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine

Publication
Swier L, Monjas L, Guskov A, Voogd A, Erkens G, slotboom d, Hirsch A (2015)
ChemBioChem, 16, 5, 819-26, 10.1002/cbic.201402673, 25676607

Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors

Publication
Huizing A, Mondal M, Hirsch A (2015)
Journal of medicinal chemistry, 58, 13, 5151-63, 10.1021/jm5014133, 25719272

Supramolecular chemistry … and beyond

Publication
Hirsch A (2015)
Angewandte Chemie (International ed. in English), 54, 38, 11013-4, 10.1002/anie.201506536, 26306880

Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors

Publication
Fittler H, Depp A, Avrutina O, Dahms S, Than M, Empting M, Kolmar H (2015)
Chembiochem : a European journal of chemical biology, 16, 17, 2441-4, 10.1002/cbic.201500447, 26426719

Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD

Publication
Allegretta G, Weidel E, Empting M, Hartmann R (2015)
European journal of medicinal chemistry, 90, 351-9, 10.1016/j.ejmech.2014.11.055, 25437621

Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster

Publication
Nesterkina M, Bilokon S, Alieksieieva T, Kravchenko I, Hirsch A (2023)
Toxicol. Rep., 10, 10.1016/j.toxrep.2023.02.009

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols

Publication
Peslalz P, Kraus F, Izzo F, Bleisch A, El Hamdaoui Y, Schulz I, Kany A, Hirsch A, Friedland K, Plietker B (2023)
Manuscript, 10.26434/chemrxiv-2023-6w94r

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle

Publication
Hamed M, Abdelsamie A, Rox K, Schütz C, Kany A, Röhrig T, Schmelz S, Blankenfeldt W, Arce-Rodriguez A, Borrero-de Acuña J, Jahn D, Rademacher J, Ringshausen F, Cramer N, Tümmler B, Hirsch A, Hartmann R, Empting M (2023)
Adv. Sci., Online, 10.1002/advs.202204443

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation

Publication
Chan A, Ho T, Irfan R, Hamid R, Rudge E, Iqbal A, Turner A, Hirsch A., Leeper F (2023)
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Publication
Hamid R, Adam S, Lacour A, Monjas L, Köhnke J, Hirsch A (2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475