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Biodynamers: self-organization-driven formation of doubly dynamic proteoids
Publication
Hirsch A,
Buhler E,
Lehn J
(2012)
Journal of the American Chemical Society, 134, 9, 4177-83, 10.1021/ja2099134, 22300496
Journal of the American Chemical Society, 134, 9, 4177-83, 10.1021/ja2099134, 22300496
Braces for the peptide backbone: insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations
Publication
Tischler M,
Nasu D,
Empting M,
Schmelz S,
Heinz D,
Rottmann P,
Kolmar H,
Buntkowsky G,
Tietze D,
Avrutina O
(2012)
Angewandte Chemie (International ed. in English), 51, 15, 3708-12, 10.1002/anie.201108983, 22374650
Angewandte Chemie (International ed. in English), 51, 15, 3708-12, 10.1002/anie.201108983, 22374650
Total synthesis of (-)-doliculide, structure-activity relationship studies and its binding to F-actin
Publication
Matcha K,
Madduri A,
Roy S,
Ziegler S,
Waldmann H,
Hirsch A,
Minnaard A
(2012)
ChemBioChem, 13, 17, 2537-48, 10.1002/cbic.201200512, 23129522
ChemBioChem, 13, 17, 2537-48, 10.1002/cbic.201200512, 23129522
'Triazole bridge': disulfide-bond replacement by ruthenium-catalyzed formation of 1,5-disubstituted 1,2,3-triazoles
Publication
Empting M,
Avrutina O,
Meusinger R,
Fabritz S,
Reinwarth M,
Biesalski M,
Voigt S,
Buntkowsky G,
Kolmar H
(2011)
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910
Angewandte Chemie (International ed. in English), 50, 22, 5207-11, 10.1002/anie.201008142, 21544910
Towards click bioconjugations on cube-octameric silsesquioxane scaffolds
Publication
Fabritz S,
Heyl D,
Bagutski V,
Empting M,
Rikowski E,
Frauendorf H,
Balog I,
Fessner W,
Schneider J,
Avrutina O,
Kolmar H
(2010)
Org. Biomol. Chem., 8, 9, 2212-8, 10.1039/b923393h, 20401398
Org. Biomol. Chem., 8, 9, 2212-8, 10.1039/b923393h, 20401398
Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase
Publication
Palme P,
Grover S,
Abdelaziz R,
Mann L,
Kany A,
Ouologuem L,
Bartel K,
Sonnenkalb L,
Reiling N,
Hirsch A,
Schnappinger D,
Rubinstein J,
Imming P,
Richter A
(2025)
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Publication
Gawriljuk V,
Oerlemans R,
Reddem E,
Gierse R,
Hirsch A,
Groves M
(2025)
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery
Publication
Liu Y,
Biesel A,
Kamal M,
Latta L,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2025)
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa
Publication
Kallergis G,
Asgari E,
Empting M,
Hirsch A,
Klawonn F,
McHardy A
(2025)
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Modular synthetic routes to biologically active indoles from lignin
Publication
Castillo-Garcia A,
Haupenthal J,
Hirsch A,
Barta K
(2025)
Green Chem., 27, 25, 7506-7512, 10.1039/d5gc01003a, 40510740
Green Chem., 27, 25, 7506-7512, 10.1039/d5gc01003a, 40510740