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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 591 to 600 of 748.

N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

Publication
Yahiaoui S, Voos K, Haupenthal J, Wichelhaus T, Frank D, Weizel L, Rotter M, Brunst S, Kramer J, Proschak E, Ducho C, Hirsch A (2021)
RSC Med. Chem., 10.1039/D1MD00187F

Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase

Publication
Jumde R, Guadigni M, Gierse R, Alhayek A, Di Zhu, Hamid Z, Johannsen S, Elgaher W, Neusens P, Nehls C, Haupenthal J, Reiling N, Hirsch A (2021)
Chemical Science, 10.1039/D1SC00330E

Citatronic Acid and Derivates thereof for use as a medicament

Publication
Pessler F., Chen F., Winterhoff M., Büssow K., Blankenfeldt W., Hirsch A. K. H., Elgaher W (2021)
Patent, WO2022223778, 2022

Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis

Publication
Rosenberger L, Essen C, Khutia A, Kühn C, Georgi K, Hirsch A, Hartmann R, Badolo L (2021)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782

Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies

Publication
Nesterkina M, Smola S, Rusakova N, Kravchenko I (2021)
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438

Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization

Publication
Della Volpe S, Linciano P, Listro R, Tumminelli E, Amadio M, Bonomo I, Elgaher W, Adam S, Hirsch A, Boeckler F, Vasile F, Rossi D, Collina S (2021)
Bioorganic chemistry, 116, 10.1016/j.bioorg.2021.105305, 34482166

Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier

Publication
Abdallah M, Hamed M, Frakolaki E, Katsamakas S, Vassilaki N, Bartenschlager R, Zoidis G, Hirsch A, Abdel-Halim M, Abadi A (2021)
European journal of medicinal chemistry, 10.1016/j.ejmech.2021.114034

Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class

Publication
Diamanti E, Hamed M, Lacour A, Bravo P, Illarionov B, Fischer M, Rottmann M, Witschel M, Hirsch A (2021)
ChemMedChem, 10.1002/cmdc.202100679, 34918860

Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021)

Publication
Voos K, Schönauer E, Alhayek A, Haupenthal J, Andreas A, Müller R, Hartmann R, Brandstetter H, Hirsch A, Ducho C (2021)
ChemMedChem, 16, 8, 1198-1198, 10.1002/cmdc.202100229

Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents

Publication
Nesterkina M, Barbalat D, Konovalova I, Shishkina S, Atakay M, Salih B, Kravchenko I (2021)
Natural product research, 35, 23, 4978-4987, 10.1080/14786419.2020.1756804, 32336164