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Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design
Publication
Axer A,
Jumde R,
Adam S,
Faust A,
Schäfers M,
Fobker M,
Koehnke J,
Hirsch A,
Gilmour R
(2021)
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H
N-Phenyl-3-Mercaptopropanamide Derivatives as Metallo-Beta-Lactamase Inhibitors for the Treatment of Bacterial Infections
Publication
Hartmann R,
Konstantinovic J,
Haupenthal J,
Hirsch A,
Kany A,
Kaya C,
Yahiaoui S,
Wichelhaus T,
Proschak E
(2021)
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, WO2021191219A1
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, WO2021191219A1
Novel PqsR Inverse Agonists
Publication
Hamed M,
Ahmed S,
Empting. M.,
Schütz C,
Hartmann R,
Röhrig T,
Kany A,
Hirsch A
(2021)
Patent, A61K31/4439; A61P31/04; C07D401/14; C07D417/14;, WO2021136805A1
Patent, A61K31/4439; A61P31/04; C07D401/14; C07D417/14;, WO2021136805A1
N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa
Publication
Yahiaoui S,
Voos K,
Haupenthal J,
Wichelhaus T,
Frank D,
Weizel L,
Rotter M,
Brunst S,
Kramer J,
Proschak E,
Ducho C,
Hirsch A
(2021)
RSC Med. Chem., 10.1039/D1MD00187F
RSC Med. Chem., 10.1039/D1MD00187F
Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Publication
Jumde R,
Guadigni M,
Gierse R,
Alhayek A,
Di Zhu,
Hamid Z,
Johannsen S,
Elgaher W,
Neusens P,
Nehls C,
Haupenthal J,
Reiling N,
Hirsch A
(2021)
Chemical Science, 10.1039/D1SC00330E
Chemical Science, 10.1039/D1SC00330E
Citatronic Acid and Derivates thereof for use as a medicament
Publication
Pessler F.,
Chen F.,
Winterhoff M.,
Büssow K.,
Blankenfeldt W.,
Hirsch A. K. H.,
Elgaher W
(2021)
Patent, WO2022223778, 2022
Patent, WO2022223778, 2022
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis
Publication
Rosenberger L,
Essen C,
Khutia A,
Kühn C,
Georgi K,
Hirsch A,
Hartmann R,
Badolo L
(2021)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies
Publication
Nesterkina M,
Smola S,
Rusakova N,
Kravchenko I
(2021)
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438
Dynamic Proteoids Generated From Dipeptide-Based Monomers
Publication
Liu Y,
Stuart M,
Buhler E,
Hirsch A
(2018)
Macromolecular rapid communications, 39, 13, 10.1002/marc.201800099, 29806088
Macromolecular rapid communications, 39, 13, 10.1002/marc.201800099, 29806088
Phage Display on the Anti-infective Target 1-Deoxy-d-xylulose-5-phosphate Synthase Leads to an Acceptor-Substrate Competitive Peptidic Inhibitor
Publication
Marcozzi A,
Masini T,
Di Zhu,
Pesce D,
Illarionov B,
Fischer M,
Herrmann A,
Hirsch A
(2018)
ChemBioChem, 19, 1, 58-65, 10.1002/cbic.201700402, 29119720
ChemBioChem, 19, 1, 58-65, 10.1002/cbic.201700402, 29119720