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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 561 to 570 of 748.

Camelid and shark single domain antibodies: structural features and therapeutic potential

Publication
Könning D, Zielonka S, Grzeschik J, Empting M, Valldorf B, Krah S, Schröter C, Sellmann C, Hock B, Kolmar H (2017)
Current opinion in structural biology, 45, 10-16, 10.1016/j.sbi.2016.10.019, 27865111

Designed Spiroketal Protein Modulation

Publication
Scheepstra M, Andrei S, Unver M, Hirsch A, Leysen S, Ottmann C, Brunsveld L, Milroy L (2017)
Angewandte Chemie (International ed. in English), 56, 20, 5480-5484, 10.1002/anie.201612504, 28407400

Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria

Publication
Monjas L, Swier L, Voogd A, Oudshoorn R, Hirsch A, Slotboom D (2016)
Med. Chem. Commun., 7, 5, 966-971, 10.1039/C6MD00022C

Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds

Publication
Zender M, Witzgall F, Drees S, Weidel E, Maurer C, Fetzner S, Blankenfeldt W, Empting M, Hartmann R (2016)
ACS chemical biology, 10.1021/acschembio.6b00156, 27082157

Discovery and Structure-Based Optimization of 2-Ureidothiophene-3-carboxylic Acids as Dual Bacterial RNA Polymerase and Viral Reverse Transcriptase Inhibitors

Publication
Elgaher W, Sharma K, Haupenthal J, Saladini F, Pires M, Real E, Mely Y, Hartmann R (2016)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.6b00730, 27339173

Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa

Publication
Thomann A, Brengel C, Börger C, Kail D, Steinbach A, Empting M, Hartmann R (2016)
ChemMedChem, 11, 22, 2522-2533, 10.1002/cmdc.201600419, 27731921

Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site

Publication
Masini T, Birkaya B, van Dijk S, Mondal M, Hekelaar J, Jäger M, van Terwisscha Scheltinga A, Patel M, Hirsch A, Moman E (2016)
Journal of enzyme inhibition and medicinal chemistry, 31, sup4, 170-175, 10.1080/14756366.2016.1201812, 27435185

Synthesis and Anticonvulsant Activity of Menthyl γ-Aminobutyrate

Publication
Nesterkina M, Kravchenko I (2016)
Chem Nat Compd, 52, 2, 237-239, 10.1007/s10600-016-1604-9

Synthesis and Pharmacological Properties of Novel Esters Based on Monocyclic Terpenes and GABA

Publication
Nesterkina M, Kravchenko I (2016)
Pharmaceuticals (Basel, Switzerland), 9, 2, 10.3390/ph9020032, 27304960

Analgesic Activity of Novel GABA Esters after Transdermal Delivery

Publication
Nesterkina M, Kravchenko I (2016)
Nat. Prod. Commun., 11, 10, 10.1177/1934578X1601101001