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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 551 to 560 of 761.

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors

Publication
Wimmer S, Hoff K, Martin B, Grewer M, Denni L, Lascorz Massanet R, Raimondi M, Bülbül E, Melesina J, Hotop S, Haupenthal J, Rohde H, Heisig P, Hirsch A, Brönstrup M, Sippl W, Holl R (2022)
Bioorganic chemistry, 131, 10.1016/j.bioorg.2022.106331, 36587505

New Ketene Dithioacetals Generated from 2-Nitroperchlorobutadiene and Investigation of Their Antibacterial, Antifungal, Anticonvulsant and Antidepressant Activities

Publication
Aydinli S, Bulut E, Deniz N, Sayil C, Komarovska-Porokhnyavets O, Lubenets V, Zvarych V, Stasevych M, Nesterkina M, Kravchenko I (2022)
Chemistry & Biodiversity, 19, 7, 10.1002/cbdv.202100931, 35674435

Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases

Publication
Alhayek A, Abdelsamie A, Schönauer E, Camberlein V, Hutterer E, Posselt G, Serwanja J, Blöchl C, Huber C, Haupenthal J, Brandstetter H, Wessler S, Hirsch A (2022)
Journal of medicinal chemistry, 65, 19, 12933-12955, 10.1021/acs.jmedchem.2c00785, 36154055

(1 R ,2 S ,5 R )-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity

Publication
Nesterkina M, Musatov V, Honcharova O, Kravchenko I (2022)
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189

An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay

Publication
Bousis S, Winkler S, Haupenthal J, Fulco F, Diamanti E, Hirsch A (2022)
International journal of molecular sciences, 23, 5, 10.3390/ijms23052637, 35269783

First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Publication
Gierse R, Oerlemans R, Reddem E, Gawriljuk V, Alhayek A, Baitinger D, Jakobi H, Laber B, Lange G, Hirsch A, Groves M (2022)
Sci. Rep., 12, 1, 10.1038/s41598-022-11205-9, 35508530

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Publication
Camberlein V, Fléau C, Sierocki P, Li L, Gealageas R, Bosc D, Guillaume V, Warenghem S, Leroux F, Rosell M, Cheng K, Medve L, Prigent M, Decanter M, Piveteau C, Biela A, Eveque M, Dumont J, Mpakali A, Giastas P, Herledan A, Couturier C, Haupenthal J, Lesire L, Hirsch A, Deprez B, Stratikos E, Bouvier M, Deprez-Poulain R (2022)
Angew. Chemie, 134, 39, 10.1002/ange.202203560

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Publication
Kaya C, Walter I, Alhayek A, Shafiei R, Jézéquel G, Andreas A, Konstantinovic J, Schönauer E, Sikandar A, Haupenthal J, Müller R, Brandstetter H, Hartmann R, Hirsch A (2022)
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824

PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE

Publication
Polish N, Nesterkina M, Karkhut A, Marintsova N, Zhurakhivska L, Volianiuk K, Pokynbroda T, Kravchenko I, Karpenko E (2022)
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956

Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Publication
Hamid R, Adam S, Lacour A, Gomez L, Hirsch A (2022)
bioRxiv, 10.1101/2022.07.04.498669