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From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa
Publication
Storz M,
Allegretta G,
Kirsch B,
Empting M,
Hartmann R
(2014)
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330
The One-Step Synthesis of Biologically Active Isochromans from Lignin-Derived Aromatic Monomers in Tunable Deep Eutectic Solvents
Publication
Kottayi A,
Afanasenko A,
Castillo-Garcia A,
Elgaher W,
Haupenthal J,
Hirsch A,
Barta K
(2025)
Chem. Eur. J., 10.1002/chem.202502769, 41351205
Chem. Eur. J., 10.1002/chem.202502769, 41351205
Identification of DksA as a novel pro-inflammatory mediator of Pseudomonas aeruginosa under conditions mimicking chronic cystic fibrosis lung infection
Publication
Wauters M,
Bollé L,
Meester G,
van den Bossche S,
Grassi L,
van Haver D,
Dufour S,
Devos S,
Impens F,
van Braeckel E,
Hirsch A,
Whiteley M,
Saelens X,
Crabbé A
(2026)
Virulence, 17, 1, 10.1080/21505594.2026.2670050, 42117785
Virulence, 17, 1, 10.1080/21505594.2026.2670050, 42117785
Current methods and applications in the study of 1-Deoxy-D-xylulose 5-phosphate synthase (DXPS)
Publication
Gawriljuk V,
Chen S,
Kramer L,
Smith N,
Diamanti E,
Hirsch A,
Freel Meyers C,
Groves M
(2026)
Methods in enzymology, 736, 61-94, 10.1016/bs.mie.2026.08.001, 42805709
Methods in enzymology, 736, 61-94, 10.1016/bs.mie.2026.08.001, 42805709
Hit-to-Lead Optimization of Energy-Coupling Factor (ECF) Transporter Inhibitors as Novel Antibiotic
Publication
Exapicheidou I,
Tsarenko A,
Zeller L,
Ibrahim H,
Baumann C,
Shams A,
Hoffmann P,
Li Y,
Kany A,
Hermann J,
Slotboom D,
Müller R,
Volkamer A,
Hamed M,
Diamanti E,
Hirsch A
(2026)
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
An investigation of phosphinamides as a functional group for medicinal chemistry
Publication
Meurillon V,
Blanchart P,
Ullah V,
Chan D,
Perry M
(2026)
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Cytochrome P450-Mediated Metabolism of Antimycobacterial Nα-Aroyl-N-aryl-phenylalanine Amides
Publication
Doering J,
Meerz E,
Seidel R,
Lang M,
Kany A,
Auriola S,
Juvonen R,
Raunio H,
Goddard R,
Zimmerman M,
Dartois V,
Hirsch A,
Dick T,
Richter A
(2026)
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
Identification of Natural-Product Inhibitors of the 2 C -Methyl- d -erythritol 4-Phosphate Pathway
Publication
Diamanti E,
Alhayek A,
Lacour A,
Shahrour M,
Willocx D,
Illarionov B,
Fischer M,
Stadler M,
Reiling N,
Herrmann J,
Müller R,
Hirsch A
(2026)
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
ACS Med. Chem. Lett., 10.1021/acsmedchemlett.6c00054
Design and Optimization of Simplified Inhibitors Targeting E. coli and K. pneumoniae IspE
Publication
Walsh D,
Hamid R,
Giele T,
Rottmann M,
Hirsch A,
Hamed M,
Reiling N
(2026)
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
RSC Med. Chem., 17, 3, 10.1039/D5MD00874C
From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds
Publication
Keddis P,
My Tu T,
Scherer H,
Kany A,
Hafez D,
Darwish S,
Abadi A,
Hirsch A,
Engel M,
Hamed M,
Horng J,
Abdel-Halim M
(2025)
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051
Eur. J. Med. Chem., 287, 10.1016/j.ejmech.2025.117348, 39947051