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Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa
Publication
Lamprecht A,
Schäfer U,
Lehr C
(2001)
Pharmaceutical research, 18, 6, 788-793, 10.1023/A:1011032328064
Pharmaceutical research, 18, 6, 788-793, 10.1023/A:1011032328064
Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration
Publication
Abdelsamie A,
Konstantinovic J,
Kany A,
Schütz C,
Kolling D,
Speicher S,
Klein A,
Shafiei R,
Bouté M,
Mundry K,
Park Y,
Loretz B,
Müller R,
Sallenave J,
Lehr C,
Koehnke J,
Rox K,
Haupenthal J,
Hirsch A
(2026)
J. Med. Chem., 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952
J. Med. Chem., 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952
A multivalent TAT-arginine-biodynamer conjugate targeting the bacterial cell envelope via specific membrane interactions
Publication
Kamal M,
Metwally W,
Bassil J,
Niebuur B,
Kraus T,
Herrmann J,
Koch M,
Hirsch A,
Loretz B,
Lee S,
Lehr C
(2026)
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 198, 10.1016/j.biopha.2026.119304, 41931850
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 198, 10.1016/j.biopha.2026.119304, 41931850
Exploring the Role of Pseudomonas aeruginosa Elastase in Lung Epithelial Barrier Dysfunction: Advancing toward Antivirulence Therapies
Publication
Shafiei R,
Alhayek A,
Hiller L,
Latta L,
Neu T,
Aljohmani A,
Abdollahibiroun S,
Schönborn E,
Yildiz D,
Schneider-Daum N,
Lehr C,
Haupenthal J,
Hirsch A
(2026)
ACS Infect. Dis., 10.1021/acsinfecdis.5c00915, 41960628
ACS Infect. Dis., 10.1021/acsinfecdis.5c00915, 41960628
Direct monitoring of intracellular polymer degradation via BODIPY dynamic dequenching
Publication
Bassil J,
Kamal M,
Gabelmann A,
Christoulaki A,
Koch M,
Hamed M,
Loretz B,
Gallei M,
Buhler E,
Lehr C,
Hirsch A,
Lee S
(2025)
Mater. Des., 256, 10.1016/j.matdes.2025.114240
Mater. Des., 256, 10.1016/j.matdes.2025.114240
Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery
Publication
Liu Y,
Biesel A,
Kamal M,
Latta L,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2025)
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Arg-biodynamers as antibiotic potentiators through interacting with Gram-negative outer membrane lipopolysaccharides
Publication
Kamal M,
Bassil J,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2024)
Eur J Pharm Biopharm, 200, 10.1016/j.ejpb.2024.114336, 38795784
Eur J Pharm Biopharm, 200, 10.1016/j.ejpb.2024.114336, 38795784
Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor
Publication
Berwanger A,
Stein S,
Kany A,
Gartner M,
Loretz B,
Lehr C,
Hirsch A,
Schulz T,
Empting M
(2023)
Journal of medicinal chemistry, 66, 15, 10782-10790, 10.1021/acs.jmedchem.3c00990, 37506283
Journal of medicinal chemistry, 66, 15, 10782-10790, 10.1021/acs.jmedchem.3c00990, 37506283
Aspherical and Spherical InvA497-Functionalized Nanocarriers for Intracellular Delivery of Anti-Infective Agents
Publication
Castoldi A,
Empting M,
Rossi C,
Mayr K,
Dersch P,
Hartmann R,
Müller R,
Gordon S,
Lehr C
(2018)
Pharm Res, 36, 1, 10.1007/s11095-018-2521-3, 30519925
Pharm Res, 36, 1, 10.1007/s11095-018-2521-3, 30519925
Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen
Publication
Berwanger A,
Stein S,
Brandner S,
Kany A,
Heinz S,
Loretz B,
Lehr C,
Hirsch A,
Lermyte F,
Schulz T,
Empting* M
(2025)
ChemMedChem, 10.1002/cmdc.202500758, 41252598
ChemMedChem, 10.1002/cmdc.202500758, 41252598