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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 511 to 520 of 761.

Positive Charge in an Antimalarial Compound Unlocks Broad-Spectrum Antibacterial Activity

Publication
Braun-Cornejo M, Platteschorre M, Vries V, Bravo P, Sonawane V, Hamed M, Haupenthal J, Reiling N, Rottmann M, Piet D, Maas P, Diamanti E, Hirsch A (2025)
JACS Au, 5, 3, 1146-1156, 10.1021/jacsau.4c00935, 40151263

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Publication
Bravo P, Diamanti E, Hamed M, Bizzarri L, Wiedemar N, Passecker A, Brancucci N, Albisetti A, Gumpp C, Illarionov B, Fischer M, Witschel M, Schehl T, Hahne H, Mäser P, Rottmann M, Hirsch A (2025)
Angew. Chem. Int. Ed., 64, 10.1002/anie.202514085, 41116297

Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity

Publication
Mielniczuk S, Hoff K, Baselious F, Li Y, Haupenthal J, Kany A, Riedner M, Rohde H, Rox K, Hirsch A, Krimm I, Sippl W, Holl R (2024)
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295

Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity

Publication
Al-Saad O, Gabr M, Darwish S, Rullo M, Pisani L, Miniero D, Liuzzi G, Kany A, Hirsch A, Abadi A, Engel M, Catto M, Abdel-Halim M (2024)
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266

Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes

Publication
Chen X, Zhao H, Wang C, Hamed M, Shang Q, Yang Y, Diao X, Sun X, Hu W, Jiang X, Zhang Y, Hirsch A, Wu D, Zhuang J (2024)
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Publication
Gawriljuk V, Godoy A, Oerlemans R, Welker L, Hirsch A, Groves M (2024)
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329

Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD

Publication
Willocx D, D'Auria L, Walsh D, Scherer H, Alhayek A, Hamed M, Borel F, Diamanti E, Hirsch A (2024)
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE

Publication
Braun-Cornejo M, Ornago C, Sonawane V, Haupenthal J, Kany A, Diamanti E, Jézéquel G, Reiling N, Blankenfeldt W, Maas P, Hirsch A (2024)
ACS omega, 10.1021/acsomega.4c05537

AI is a viable alternative to high throughput screening: a 318-target study

Publication
Wallach I, Hirsch, Anna K. H. et al. (2024)
Sci. Rep., 14, 1, 10.1038/s41598-024-54655-z, 38565852

Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Publication
Geißler A, Junca H, Kany A, Daumann L, Hirsch A, Pieper D, Sieber S (2024)
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115