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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 511 to 520 of 757.

Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols

Publication
Peslalz P, Kraus F, Izzo F, Bleisch A, El Hamdaoui Y, Schulz I, Kany A, Hirsch A, Friedland K, Plietker B (2023)
Manuscript, 10.26434/chemrxiv-2023-6w94r

Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle

Publication
Hamed M, Abdelsamie A, Rox K, Schütz C, Kany A, Röhrig T, Schmelz S, Blankenfeldt W, Arce-Rodriguez A, Borrero-de Acuña J, Jahn D, Rademacher J, Ringshausen F, Cramer N, Tümmler B, Hirsch A, Hartmann R, Empting M (2023)
Adv. Sci., Online, 10.1002/advs.202204443

Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation

Publication
Chan A, Ho T, Irfan R, Hamid R, Rudge E, Iqbal A, Turner A, Hirsch A., Leeper F (2023)
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602

1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Publication
Hamid R, Adam S, Lacour A, Monjas L, Köhnke J, Hirsch A (2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475

First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Publication
Gierse R, Oerlemans R, Reddem E, Gawriljuk V, Alhayek A, Baitinger D, Jakobi H, Laber B, Lange G, Hirsch A, Groves M (2022)
Sci. Rep., 12, 1, 10.1038/s41598-022-11205-9, 35508530

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Publication
Camberlein V, Fléau C, Sierocki P, Li L, Gealageas R, Bosc D, Guillaume V, Warenghem S, Leroux F, Rosell M, Cheng K, Medve L, Prigent M, Decanter M, Piveteau C, Biela A, Eveque M, Dumont J, Mpakali A, Giastas P, Herledan A, Couturier C, Haupenthal J, Lesire L, Hirsch A, Deprez B, Stratikos E, Bouvier M, Deprez-Poulain R (2022)
Angew. Chemie, 134, 39, 10.1002/ange.202203560

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Publication
Kaya C, Walter I, Alhayek A, Shafiei R, Jézéquel G, Andreas A, Konstantinovic J, Schönauer E, Sikandar A, Haupenthal J, Müller R, Brandstetter H, Hartmann R, Hirsch A (2022)
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824

PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE

Publication
Polish N, Nesterkina M, Karkhut A, Marintsova N, Zhurakhivska L, Volianiuk K, Pokynbroda T, Kravchenko I, Karpenko E (2022)
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956

Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Publication
Hamid R, Adam S, Lacour A, Gomez L, Hirsch A (2022)
bioRxiv, 10.1101/2022.07.04.498669

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism

Publication
Chen F, Elgaher W, Winterhoff M, Büssow K, Waqas F, Graner E, Pires-Afonso Y, Casares Perez L, La Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch A, Pessler F (2022)
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026