Search
In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment
Publication
Allegretta G,
Maurer C,
Eberhard J,
Maura D,
Hartmann R,
Rahme L,
Empting M
(2017)
Frontiers in microbiology, 8, 10.3389/fmicb.2017.00924, 28596760
Frontiers in microbiology, 8, 10.3389/fmicb.2017.00924, 28596760
Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections
Publication
Thomann A,
Mello Martins A,
Brengel C,
Empting M,
Hartmann R
(2016)
ACS chemical biology, 11, 5, 1279-86, 10.1021/acschembio.6b00117, 26882081
ACS chemical biology, 11, 5, 1279-86, 10.1021/acschembio.6b00117, 26882081
Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa
Publication
Sahner J,
Empting M,
Kamal A,
Weidel E,
Groh M,
Börger C,
Hartmann R
(2015)
European journal of medicinal chemistry, 96, 14-21, 10.1016/j.ejmech.2015.04.007, 25874327
European journal of medicinal chemistry, 96, 14-21, 10.1016/j.ejmech.2015.04.007, 25874327
From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa
Publication
Storz M,
Allegretta G,
Kirsch B,
Empting M,
Hartmann R
(2014)
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330
The One-Step Synthesis of Biologically Active Isochromans from Lignin-Derived Aromatic Monomers in Tunable Deep Eutectic Solvents
Publication
Kottayi A,
Afanasenko A,
Castillo-Garcia A,
Elgaher W,
Haupenthal J,
Hirsch A,
Barta K
(2025)
Chem. Eur. J., 10.1002/chem.202502769, 41351205
Chem. Eur. J., 10.1002/chem.202502769, 41351205
Identification of DksA as a novel pro-inflammatory mediator of Pseudomonas aeruginosa under conditions mimicking chronic cystic fibrosis lung infection
Publication
Wauters M,
Bollé L,
Meester G,
van den Bossche S,
Grassi L,
van Haver D,
Dufour S,
Devos S,
Impens F,
van Braeckel E,
Hirsch A,
Whiteley M,
Saelens X,
Crabbé A
(2026)
Virulence, 17, 1, 10.1080/21505594.2026.2670050, 42117785
Virulence, 17, 1, 10.1080/21505594.2026.2670050, 42117785
Multiparameter Optimization of Pseudomonas aeruginosa Elastase Inhibitors for Systemic Administration
Publication
Abdelsamie A,
Konstantinovic J,
Kany A,
Schütz C,
Kolling D,
Speicher S,
Klein A,
Shafiei R,
Bouté M,
Mundry K,
Park Y,
Loretz B,
Müller R,
Sallenave J,
Lehr C,
Koehnke J,
Rox K,
Haupenthal J,
Hirsch A
(2026)
J. Med. Chem., 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952
J. Med. Chem., 69, 4, 4160-4186, 10.1021/acs.jmedchem.5c02788, 41642952
Hit-to-Lead Optimization of Energy-Coupling Factor (ECF) Transporter Inhibitors as Novel Antibiotic
Publication
Exapicheidou I,
Tsarenko A,
Zeller L,
Ibrahim H,
Baumann C,
Shams A,
Hoffmann P,
Li Y,
Kany A,
Hermann J,
Slotboom D,
Müller R,
Volkamer A,
Hamed M,
Diamanti E,
Hirsch A
(2026)
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
Journal of medicinal chemistry, 69, 12, 14069-14084, 10.1021/acs.jmedchem.5c02721, 42249838
An investigation of phosphinamides as a functional group for medicinal chemistry
Publication
Meurillon V,
Blanchart P,
Ullah V,
Chan D,
Perry M
(2026)
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Med Chem Res, 35, 1, 118-134, 10.1007/s00044-025-03498-y
Cytochrome P450-Mediated Metabolism of Antimycobacterial Nα-Aroyl-N-aryl-phenylalanine Amides
Publication
Doering J,
Meerz E,
Seidel R,
Lang M,
Kany A,
Auriola S,
Juvonen R,
Raunio H,
Goddard R,
Zimmerman M,
Dartois V,
Hirsch A,
Dick T,
Richter A
(2026)
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659
ACS Infect. Dis., 12, 6, 10.1021/acsinfecdis.6c00100, 42227659