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Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity
Publication
Abdelsamie A,
Hamed M,
Schütz C,
Röhrig T,
Kany A,
Schmelz S,
Blankenfeldt W,
Hirsch A,
Hartmann R,
Empting M
(2024)
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991
In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment
Publication
Allegretta G,
Maurer C,
Eberhard J,
Maura D,
Hartmann R,
Rahme L,
Empting M
(2017)
Frontiers in microbiology, 8, 10.3389/fmicb.2017.00924, 28596760
Frontiers in microbiology, 8, 10.3389/fmicb.2017.00924, 28596760
Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections
Publication
Thomann A,
Mello Martins A,
Brengel C,
Empting M,
Hartmann R
(2016)
ACS chemical biology, 11, 5, 1279-86, 10.1021/acschembio.6b00117, 26882081
ACS chemical biology, 11, 5, 1279-86, 10.1021/acschembio.6b00117, 26882081
Identification of a new protein-RNA interaction inhibitor targeting the KH34 region of the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2/IMP2)
Publication
Berwanger A,
Wagner K,
Both S,
Kany A,
Mazlom K,
Hirsch A,
Kiemer A,
Empting M
(2026)
European journal of medicinal chemistry, 307, 10.1016/j.ejmech.2026.118624, 41687271
European journal of medicinal chemistry, 307, 10.1016/j.ejmech.2026.118624, 41687271
Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen
Publication
Berwanger A,
Stein S,
Brandner S,
Kany A,
Heinz S,
Loretz B,
Lehr C,
Hirsch A,
Lermyte F,
Schulz T,
Empting* M
(2025)
ChemMedChem, 10.1002/cmdc.202500758, 41252598
ChemMedChem, 10.1002/cmdc.202500758, 41252598
The One-Step Synthesis of Biologically Active Isochromans from Lignin-Derived Aromatic Monomers in Tunable Deep Eutectic Solvents
Publication
Kottayi A,
Afanasenko A,
Castillo-Garcia A,
Elgaher W,
Haupenthal J,
Hirsch A,
Barta K
(2025)
Chem. Eur. J., 10.1002/chem.202502769, 41351205
Chem. Eur. J., 10.1002/chem.202502769, 41351205
Synthesis and Anticonvulsant Activity of Menthyl γ-Aminobutyrate
Publication
Nesterkina M,
Kravchenko I
(2016)
Chem Nat Compd, 52, 2, 237-239, 10.1007/s10600-016-1604-9
Chem Nat Compd, 52, 2, 237-239, 10.1007/s10600-016-1604-9
Synthesis and Pharmacological Properties of Novel Esters Based on Monocyclic Terpenes and GABA
Publication
Nesterkina M,
Kravchenko I
(2016)
Pharmaceuticals (Basel, Switzerland), 9, 2, 10.3390/ph9020032, 27304960
Pharmaceuticals (Basel, Switzerland), 9, 2, 10.3390/ph9020032, 27304960
Analgesic Activity of Novel GABA Esters after Transdermal Delivery
Publication
Nesterkina M,
Kravchenko I
(2016)
Nat. Prod. Commun., 11, 10, 10.1177/1934578X1601101001
Nat. Prod. Commun., 11, 10, 10.1177/1934578X1601101001
Single-domain antibodies for biomedical applications
Publication
Krah S,
Schröter C,
Zielonka S,
Empting M,
Valldorf B,
Kolmar H
(2016)
Immunopharmacol. Immunotoxicol., 38, 1, 21-8, 10.3109/08923973.2015.1102934, 26551147
Immunopharmacol. Immunotoxicol., 38, 1, 21-8, 10.3109/08923973.2015.1102934, 26551147