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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 501 to 510 of 784.

Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape

Publication
Lee S, Nasr S, Rasheed S, Liu Y, Hartwig O, Kaya C, Boese A, Koch M, Herrmann J, Müller R, Loretz B, Buhler E, Hirsch A, Lehr C (2022)
Journal of controlled release : official journal of the Controlled Release Society, 353, 915-929, 10.1016/j.jconrel.2022.12.018, 36521693

An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

Publication
Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, Schneider-Daum N, Fuhrmann G, Pagès J, Lehr C (2022)
Advanced healthcare materials, 11, 5, 10.1002/adhm.202101180, 34614289

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Publication
Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, Hartmann R, Desmaele D, Loretz B, Couvreur P, Lehr C (2020)
Angewandte Chemie (International ed. in English), 10.1002/anie.202001407, 32243047

Identification of a new protein-RNA interaction inhibitor targeting the KH34 region of the insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2/IMP2)

Publication
Berwanger A, Wagner K, Both S, Kany A, Mazlom K, Hirsch A, Kiemer A, Empting M (2026)
Eur. J. Med. Chem., 307, 10.1016/j.ejmech.2026.118624, 41687271

Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen

Publication
Berwanger A, Stein S, Brandner S, Kany A, Heinz S, Loretz B, Lehr C, Hirsch A, Lermyte F, Schulz T, Empting* M (2025)
ChemMedChem, 10.1002/cmdc.202500758, 41252598

Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity

Publication
Abdelsamie A, Hamed M, Schütz C, Röhrig T, Kany A, Schmelz S, Blankenfeldt W, Hirsch A, Hartmann R, Empting M (2024)
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

Publication
Della Volpe S, Nasti R, Queirolo M, Unver M, Jumde V, Dömling A, Vasile F, Potenza D, Ambrosio F, Costa G, Alcaro S, Zucal C, Provenzani A, Di Giacomo M, Rossi D, Hirsch A, Collina S (2019)
ACS Med. Chem. Lett., 10, 4, 615-620, 10.1021/acsmedchemlett.8b00600, 30996806

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

Publication
Allegretta G, Maurer C, Eberhard J, Maura D, Hartmann R, Rahme L, Empting M (2017)
Frontiers in microbiology, 8, 10.3389/fmicb.2017.00924, 28596760

Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections

Publication
Thomann A, Mello Martins A, Brengel C, Empting M, Hartmann R (2016)
ACS chemical biology, 11, 5, 1279-86, 10.1021/acschembio.6b00117, 26882081

Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa

Publication
Sahner J, Empting M, Kamal A, Weidel E, Groh M, Börger C, Hartmann R (2015)
European journal of medicinal chemistry, 96, 14-21, 10.1016/j.ejmech.2015.04.007, 25874327