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Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections
Publication
Ho D,
Murgia X,
Rossi C,
Christmann R,
Hüfner de Mello Martins A,
Koch M,
Andreas A,
Herrmann J,
Müller R,
Empting M,
Hartmann R,
Desmaele D,
Loretz B,
Couvreur P,
Lehr C
(2020)
Angewandte Chemie (International ed. in English), 10.1002/anie.202001407, 32243047
Angewandte Chemie (International ed. in English), 10.1002/anie.202001407, 32243047
An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability
Publication
Richter R,
Kamal M,
Koch M,
Niebuur B,
Huber A,
Goes A,
Volz C,
Vergalli J,
Kraus T,
Müller R,
Schneider-Daum N,
Fuhrmann G,
Pagès J,
Lehr C
(2022)
Advanced healthcare materials, 11, 5, 10.1002/adhm.202101180, 34614289
Advanced healthcare materials, 11, 5, 10.1002/adhm.202101180, 34614289
From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa
Publication
Storz M,
Allegretta G,
Kirsch B,
Empting M,
Hartmann R
(2014)
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330
Organic & biomolecular chemistry, 12, 32, 6094-104, 10.1039/c4ob00707g, 24909330
Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies
Publication
Della Volpe S,
Nasti R,
Queirolo M,
Unver M,
Jumde V,
Dömling A,
Vasile F,
Potenza D,
Ambrosio F,
Costa G,
Alcaro S,
Zucal C,
Provenzani A,
Di Giacomo M,
Rossi D,
Hirsch A,
Collina S
(2019)
ACS Med. Chem. Lett., 10, 4, 615-620, 10.1021/acsmedchemlett.8b00600, 30996806
ACS Med. Chem. Lett., 10, 4, 615-620, 10.1021/acsmedchemlett.8b00600, 30996806
In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment
Publication
Allegretta G,
Maurer C,
Eberhard J,
Maura D,
Hartmann R,
Rahme L,
Empting M
(2017)
Frontiers in microbiology, 8, 10.3389/fmicb.2017.00924, 28596760
Frontiers in microbiology, 8, 10.3389/fmicb.2017.00924, 28596760
Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections
Publication
Thomann A,
Mello Martins A,
Brengel C,
Empting M,
Hartmann R
(2016)
ACS chemical biology, 11, 5, 1279-86, 10.1021/acschembio.6b00117, 26882081
ACS chemical biology, 11, 5, 1279-86, 10.1021/acschembio.6b00117, 26882081
Exploring the chemical space of ureidothiophene-2-carboxylic acids as inhibitors of the quorum sensing enzyme PqsD from Pseudomonas aeruginosa
Publication
Sahner J,
Empting M,
Kamal A,
Weidel E,
Groh M,
Börger C,
Hartmann R
(2015)
European journal of medicinal chemistry, 96, 14-21, 10.1016/j.ejmech.2015.04.007, 25874327
European journal of medicinal chemistry, 96, 14-21, 10.1016/j.ejmech.2015.04.007, 25874327
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity
Publication
Abdelsamie A,
Hamed M,
Schütz C,
Röhrig T,
Kany A,
Schmelz S,
Blankenfeldt W,
Hirsch A,
Hartmann R,
Empting M
(2024)
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991
Eur. J. Med. Chem., 276, 10.1016/j.ejmech.2024.116685, 39042991
Supramolecular chemistry … and beyond
Publication
Hirsch A
(2015)
Angewandte Chemie (International ed. in English), 54, 38, 11013-4, 10.1002/anie.201506536, 26306880
Angewandte Chemie (International ed. in English), 54, 38, 11013-4, 10.1002/anie.201506536, 26306880
Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors
Publication
Fittler H,
Depp A,
Avrutina O,
Dahms S,
Than M,
Empting M,
Kolmar H
(2015)
Chembiochem : a European journal of chemical biology, 16, 17, 2441-4, 10.1002/cbic.201500447, 26426719
Chembiochem : a European journal of chemical biology, 16, 17, 2441-4, 10.1002/cbic.201500447, 26426719