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Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model
Publication
Sousa C,
Coimbra J,
Richter R,
Morais-Cabral J,
Ramos M,
Lehr C,
Fernandes P,
Gameiro P
(2022)
Biochimica et biophysica acta. Biomembranes, 1864, 3, 10.1016/j.bbamem.2021.183838, 34896074
Biochimica et biophysica acta. Biomembranes, 1864, 3, 10.1016/j.bbamem.2021.183838, 34896074
Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier
Publication
Kuehn A,
Kletting S,
Souza Carvalho-Wodarz C,
Repnik U,
Griffiths G,
Fischer U,
Meese E,
Huwer H,
Wirth D,
May T,
Schneider-Daum N,
Lehr C
(2016)
ALTEX, 33, 3, 251-60, 10.14573/altex.1511131, 26985677
ALTEX, 33, 3, 251-60, 10.14573/altex.1511131, 26985677
Optical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus
Publication
Kirch J,
Schneider A,
Abou B,
Hopf A,
Schaefer U,
Schneider M,
Schall C,
Wagner C,
Lehr C
(2012)
Proceedings of the National Academy of Sciences of the United States of America, 109, 45, 18355-18360, 10.1073/pnas.1214066109
Proceedings of the National Academy of Sciences of the United States of America, 109, 45, 18355-18360, 10.1073/pnas.1214066109
A three-dimensional coculture of enterocytes, monocytes and dendritic cells to model inflamed intestinal mucosa in vitro
Publication
Leonard F,
Collnot E,
Lehr C
(2010)
Molecular pharmaceutics, 7, 6, 2103-2119, 10.1021/mp1000795
Molecular pharmaceutics, 7, 6, 2103-2119, 10.1021/mp1000795
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms
Publication
Schütz C,
Ho D,
Hamed M,
Abdelsamie A,
Röhrig T,
Herr C,
Kany A,
Rox K,
Schmelz S,
Siebenbürger L,
Wirth M,
Börger C,
Yahiaoui S,
Bals R,
Scrima A,
Blankenfeldt W,
Horstmann J,
Christmann R,
Murgia X,
Koch M,
Berwanger A,
Loretz B,
Hirsch A,
Hartmann R,
Lehr C,
Empting M
(2021)
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8, 12, 10.1002/advs.202004369, 34165899
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8, 12, 10.1002/advs.202004369, 34165899
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria
Publication
Richter R,
Kamal M,
García-Rivera M,
Kaspar J,
Junk M,
Elgaher W,
Srikakulam S,
Gress A,
Beckmann A,
Grißmer A,
Meier C,
Vielhaber M,
Kalinina O,
Hirsch A,
Hartmann R,
Brönstrup M,
Schneider-Daum N,
Lehr C
(2020)
Materials today. Bio, 8, 10.1016/j.mtbio.2020.100084, 33313504
Materials today. Bio, 8, 10.1016/j.mtbio.2020.100084, 33313504
pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers
Publication
Lee S,
Kaya C,
Jang H,
Koch M,
Loretz B,
Buhler E,
Lehr C,
Hirsch A
(2020)
Mater. Chem. Front., 4, 3, 905-909, 10.1039/C9QM00651F
Mater. Chem. Front., 4, 3, 905-909, 10.1039/C9QM00651F
Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection
Publication
Murgia X,
Kany A,
Herr C,
Ho D,
Rossi C,
Bals R,
Lehr C,
Hirsch A,
Hartmann R,
Empting M,
Röhrig T
(2020)
Scientific Reports, 10, 1, 10.1038/s41598-020-73459-5, 33020513
Scientific Reports, 10, 1, 10.1038/s41598-020-73459-5, 33020513
Transferring Microclusters of P. aeruginosa Biofilms to the Air-Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin
Publication
Horstmann J,
Laric A,
Boese A,
Yildiz D,
Röhrig T,
Empting M,
Frank N,
Krug D,
Müller R,
Schneider-Daum N,
Souza Carvalho-Wodarz C,
Lehr C
(2022)
ACS infectious diseases, 8, 1, 137-149, 10.1021/acsinfecdis.1c00444, 34919390
ACS infectious diseases, 8, 1, 137-149, 10.1021/acsinfecdis.1c00444, 34919390
Intracellular Dynamics of Extracellular Vesicles by Segmented Trajectory Analysis
Publication
Rautaniemi K,
John T,
Richter M,
Huck B,
Zini J,
Loretz B,
Lehr C,
Vuorimaa-Laukkanen E,
Lisitsyna E,
Laaksonen T
(2022)
Analytical chemistry, 94, 51, 17770-17778, 10.1021/acs.analchem.2c02928, 36512439
Analytical chemistry, 94, 51, 17770-17778, 10.1021/acs.analchem.2c02928, 36512439