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Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models
Publication
Hittinger M,
Juntke J,
Kletting S,
Schneider-Daum N,
de Souza Carvalho C,
Lehr C
(2015)
Advanced Drug Delivery Reviews, 85, 44-56, 10.1016/j.addr.2014.10.011, 25453270
Advanced Drug Delivery Reviews, 85, 44-56, 10.1016/j.addr.2014.10.011, 25453270
Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs
Publication
Nasti R,
Rossi D,
Amadio M,
Pascale A,
Unver M,
Hirsch A,
Collina S
(2017)
Journal of medicinal chemistry, 60, 20, 8257-8267, 10.1021/acs.jmedchem.6b01871, 28587461
Journal of medicinal chemistry, 60, 20, 8257-8267, 10.1021/acs.jmedchem.6b01871, 28587461
Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)
Publication
Floroiu A,
Loretz B,
Krämer J,
Lehr C
(2024)
Eur J Pharm Biopharm, 197, 10.1016/j.ejpb.2024.114206, 38316234
Eur J Pharm Biopharm, 197, 10.1016/j.ejpb.2024.114206, 38316234
The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of Pseudomonas aeruginosa LecA
Publication
Leusmann S,
Siebs E,
Kuhaudomlarp S,
Varrot A,
Imberty A,
Kuhn B,
Lerner C,
Grether U,
Titz A
(2025)
Angewandte Chemie (International ed. in English), 64, 50, 10.1002/anie.202508864, 41178200
Angewandte Chemie (International ed. in English), 64, 50, 10.1002/anie.202508864, 41178200
Drug transport across pulmonary epithelial cell monolayers: effects of particle size, apical liquid volume, and deposition technique
Publication
Bur M,
Huwer H,
Muys L,
Lehr C
(2010)
Journal of aerosol medicine and pulmonary drug delivery, 23, 3, 119-27, 10.1089/jamp.2009.0757, 20073555
Journal of aerosol medicine and pulmonary drug delivery, 23, 3, 119-27, 10.1089/jamp.2009.0757, 20073555
Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties
Publication
Huck B,
Murgia X,
Frisch S,
Hittinger M,
Hidalgo A,
Loretz B,
Lehr C
(2022)
Advanced Drug Delivery Reviews, 183, 10.1016/j.addr.2022.114141, 35149123
Advanced Drug Delivery Reviews, 183, 10.1016/j.addr.2022.114141, 35149123
A Custom-Made Device for Reproducibly Depositing Pre-metered Doses of Nebulized Drugs on Pulmonary Cells in vitro
Publication
Horstmann J,
Thorn C,
Carius P,
Graef F,
Murgia X,
Souza Carvalho-Wodarz C,
Lehr C
(2021)
Frontiers in Bioengineering and Biotechnology, 9, 10.3389/fbioe.2021.643491, 33968912
Frontiers in Bioengineering and Biotechnology, 9, 10.3389/fbioe.2021.643491, 33968912
Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in E. coli for Structure-Based Drug Design
Publication
Kolling D,
Haupenthal J,
Hirsch A,
Köhnke J
(2023)
ChemBioChem, 10.1002/cbic.202300185, 37195753
ChemBioChem, 10.1002/cbic.202300185, 37195753
A new bactericidal thiourea antibiotic against drug-resistant Staphylococcus aureus with in vivo activity and no detectable resistance
Publication
Czekanska M,
Akhir A,
Arts M,
Kany A,
Saxena D,
Maitra R,
Dier A,
Sokolenko I,
Knopp C,
Kinsinger T,
Hirsch A,
Verma S,
Schneider T,
Titz A,
Chopra S
(2026)
European journal of medicinal chemistry, 10.1016/j.ejmech.2026.119078
European journal of medicinal chemistry, 10.1016/j.ejmech.2026.119078
Drug delivery to the inflamed intestinal mucosa- targeting technologies and human cell culture models for better therapies of IBD
Publication
Olga H,
Shetab Boushehri Maryam A,
Shalaby Karim S,
Brigitta L,
Alf L,
Claus-Michael L
(2021)
Advanced Drug Delivery Reviews, 10.1016/j.addr.2021.113828, 34157320
Advanced Drug Delivery Reviews, 10.1016/j.addr.2021.113828, 34157320