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Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS)
Publication
Floroiu A,
Loretz B,
Krämer J,
Lehr C
(2024)
Eur J Pharm Biopharm, 197, 10.1016/j.ejpb.2024.114206, 38316234
Eur J Pharm Biopharm, 197, 10.1016/j.ejpb.2024.114206, 38316234
Drug transport across pulmonary epithelial cell monolayers: effects of particle size, apical liquid volume, and deposition technique
Publication
Bur M,
Huwer H,
Muys L,
Lehr C
(2010)
Journal of aerosol medicine and pulmonary drug delivery, 23, 3, 119-27, 10.1089/jamp.2009.0757, 20073555
Journal of aerosol medicine and pulmonary drug delivery, 23, 3, 119-27, 10.1089/jamp.2009.0757, 20073555
Models using native tracheobronchial mucus in the context of pulmonary drug delivery research: Composition, structure and barrier properties
Publication
Huck B,
Murgia X,
Frisch S,
Hittinger M,
Hidalgo A,
Loretz B,
Lehr C
(2022)
Advanced Drug Delivery Reviews, 183, 10.1016/j.addr.2022.114141, 35149123
Advanced Drug Delivery Reviews, 183, 10.1016/j.addr.2022.114141, 35149123
A Custom-Made Device for Reproducibly Depositing Pre-metered Doses of Nebulized Drugs on Pulmonary Cells in vitro
Publication
Horstmann J,
Thorn C,
Carius P,
Graef F,
Murgia X,
Souza Carvalho-Wodarz C,
Lehr C
(2021)
Frontiers in Bioengineering and Biotechnology, 9, 10.3389/fbioe.2021.643491, 33968912
Frontiers in Bioengineering and Biotechnology, 9, 10.3389/fbioe.2021.643491, 33968912
Facile Production of the Pseudomonas aeruginosa Virulence Factor LasB in E. coli for Structure-Based Drug Design
Publication
Kolling D,
Haupenthal J,
Hirsch A,
Köhnke J
(2023)
ChemBioChem, 10.1002/cbic.202300185, 37195753
ChemBioChem, 10.1002/cbic.202300185, 37195753
Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery
Publication
de Souza Carvalho C,
Daum N,
Lehr C
(2014)
Advanced Drug Delivery Reviews, 75, 129-140, 10.1016/j.addr.2014.05.014, 24880145
Advanced Drug Delivery Reviews, 75, 129-140, 10.1016/j.addr.2014.05.014, 24880145
Drug delivery to the inflamed intestinal mucosa- targeting technologies and human cell culture models for better therapies of IBD
Publication
Olga H,
Shetab Boushehri Maryam A,
Shalaby Karim S,
Brigitta L,
Alf L,
Claus-Michael L
(2021)
Advanced Drug Delivery Reviews, 10.1016/j.addr.2021.113828, 34157320
Advanced Drug Delivery Reviews, 10.1016/j.addr.2021.113828, 34157320
A Monoclonal Human Alveolar Epithelial Cell Line ("Arlo") with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections
Publication
Carius P,
Jungmann A,
Bechtel M,
Grißmer A,
Boese A,
Gasparoni G,
Salhab A,
Seipelt R,
Urbschat K,
Richter C,
Meier C,
Bojkova D,
Cinatl J,
Walter J,
Schneider-Daum N,
Lehr C
(2023)
Adv. Sci., 10, 8, 10.1002/advs.202207301, 36748276
Adv. Sci., 10, 8, 10.1002/advs.202207301, 36748276
Second Generation Tiancimycin-Based Antibody–Drug Conjugates Enabled by Highly Efficient Semi-synthetic Approach Specifically Targeting B-Cell Malignancies
Publication
Kiefer A,
Thirugnanasambantham P,
Jin Y,
Steele A,
Hwang D,
Jiang Y,
Adhikari A,
Yang D,
Chang J,
Tafesse R,
Rader C,
Muthusamy N,
Shen B
(2025)
JACS Au, 10.1021/jacsau.5c00353
JACS Au, 10.1021/jacsau.5c00353
Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa - A first in vivo study in human patients
Publication
Schmidt C,
Lautenschlaeger C,
Collnot E,
Schumann M,
Bojarski C,
Schulzke J,
Lehr C,
Stallmach A
(2013)
Journal of Controlled Release, 165, 2, 139-145, 10.1016/j.jconrel.2012.10.019, 23127508
Journal of Controlled Release, 165, 2, 139-145, 10.1016/j.jconrel.2012.10.019, 23127508