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Targeting the Energy-Coupling Factor Transporters: A Novel Antibiotic Drug Target in Streptococcus pneumoniae
Publication
Diamanti E,
Cremers A,
Li Y,
Exapicheidou I,
Baumann C,
Gibson P,
Shams A,
Martin L,
Becker R,
Setyawati I,
Zeimetz L,
Haupenthal J,
Witschel M,
Slotboom D,
Herrmann J,
Rox K,
Hamed M,
Veening J,
Hirsch A
(2026)
Journal of medicinal chemistry, 69, 12, 14054-14068, 10.1021/acs.jmedchem.5c03638, 42284150
Journal of medicinal chemistry, 69, 12, 14054-14068, 10.1021/acs.jmedchem.5c03638, 42284150
DVD-IgG1 antibody-drug conjugates: Expanding the landscape of targeted cancer therapy
Publication
Kiefer A,
Steele A,
Rader C,
Shen B
(2026)
Current opinion in chemical biology, 92, 10.1016/j.cbpa.2026.102653, 41734646
Current opinion in chemical biology, 92, 10.1016/j.cbpa.2026.102653, 41734646
The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets
Publication
Hirsch A,
Diederich F
(2008)
CHIMIA, 62, 4, 226-230, 10.2533/chimia.2008.226
CHIMIA, 62, 4, 226-230, 10.2533/chimia.2008.226
Consistent Prediction of Mutation Effect on Drug Binding in HIV-1 Protease Using Alchemical Calculations
Publication
Bastys T,
Gapsys V,
Doncheva N,
Kaiser R,
Groot B,
Kalinina O
(2018)
Journal of chemical theory and computation, 14, 7, 3397-3408, 10.1021/acs.jctc.7b01109, 29847122
Journal of chemical theory and computation, 14, 7, 3397-3408, 10.1021/acs.jctc.7b01109, 29847122
Simulated tempering-enhanced umbrella sampling improves convergence of free energy calculations of drug membrane permeation
Publication
Sousa C,
Becker R,
Lehr C,
Kalinina O,
Hub J
(2022)
bioRxiv, 10.1101/2022.11.13.516136
bioRxiv, 10.1101/2022.11.13.516136
Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization
Publication
Fittler H,
Avrutina O,
Glotzbach B,
Empting M,
Kolmar H
(2013)
Org. Biomol. Chem., 11, 11, 1848-57, 10.1039/c3ob27469a, 23361403
Org. Biomol. Chem., 11, 11, 1848-57, 10.1039/c3ob27469a, 23361403
Pulmonary drug delivery: from generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges
Publication
Ruge C,
Kirch J,
Lehr C
(2013)
The Lancet. Respiratory medicine, 1, 5, 402-413, 10.1016/S2213-2600(13)70072-9, 24429205
The Lancet. Respiratory medicine, 1, 5, 402-413, 10.1016/S2213-2600(13)70072-9, 24429205
Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis
Publication
Salomon J,
Galeron P,
Schulte N,
Morow P,
Severynse-Stevens D,
Huwer H,
Daum N,
Lehr C,
Hickey A,
Ehrhardt C
(2013)
Therapeutic delivery, 4, 8, 915-923, 10.4155/tde.13.62
Therapeutic delivery, 4, 8, 915-923, 10.4155/tde.13.62
In vitro models for evaluating safety and efficacy of novel technologies for skin drug delivery
Publication
Planz V,
Lehr C,
Windbergs M
(2016)
Journal of Controlled Release, 242, 89-104, 10.1016/j.jconrel.2016.09.002
Journal of Controlled Release, 242, 89-104, 10.1016/j.jconrel.2016.09.002
Label-free analysis of drug delivery systems and cellular interaction studies using confocal Raman microscopy
Publication
Kann B
(2016)
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