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Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships
Publication
Steele A,
Kiefer A,
Hwang D,
Yang D,
Teijaro C,
Adhikari A,
Rader C,
Shen B
(2023)
Journal of medicinal chemistry, 66, 2, 1562-1573, 10.1021/acs.jmedchem.2c01771, 36599039
Journal of medicinal chemistry, 66, 2, 1562-1573, 10.1021/acs.jmedchem.2c01771, 36599039
Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening
Publication
Di Zhu,
Johannsen S,
Masini T,
Simonin C,
Haupenthal J,
Illarionov B,
Andreas A,
Awale M,
Gierse R,
van der Laan T,
van der Vlag R,
Nasti R,
Poizat M,
Buhler E,
Reiling N,
Müller R,
Fischer M,
Reymond J,
Hirsch A
(2022)
Chem. Sci., 13, 36, 10686-10698, 10.1039/D2SC02371G, 36320685
Chem. Sci., 13, 36, 10686-10698, 10.1039/D2SC02371G, 36320685
Ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery system intended for the treatment of bacterial infections in cystic fibrosis
Publication
Torge A,
Wagner S,
Chaves P,
Oliveira E,
Guterres S,
Pohlmann A,
Titz A,
Schneider M,
Beck R
(2017)
Int J Pharm, 527, 1-2, 92-102, 10.1016/j.ijpharm.2017.05.013, 28499793
Int J Pharm, 527, 1-2, 92-102, 10.1016/j.ijpharm.2017.05.013, 28499793
A new cell line-based coculture model of the human air-blood barrier to evaluate the interaction with aerosolized drug carriers
Publication
Kletting S
(2016)
Book
Book
Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin
Publication
Mondal M,
Unver M,
Pal A,
Bakker M,
Berrier S,
Hirsch A
(2016)
Chem. Eur. J., 22, 42, 14826-14830, 10.1002/chem.201603001, 27604032
Chem. Eur. J., 22, 42, 14826-14830, 10.1002/chem.201603001, 27604032
A new Pharmaceutical Aerosol Deposition Device on Cell Cultures (PADDOCC) to evaluate pulmonary drug absorption for metered dose dry powder formulations
Publication
Hein S,
Bur M,
Schaefer U,
Lehr C
(2011)
European Journal of Pharmaceutics and Biopharmaceutics, 77, 1, 132-138, 10.1016/j.ejpb.2010.10.003
European Journal of Pharmaceutics and Biopharmaceutics, 77, 1, 132-138, 10.1016/j.ejpb.2010.10.003
Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism
Publication
Park Y,
Dahlem C,
Meyer M,
Kiemer A,
Müller R,
Herrmann J
(2022)
Molecules (Basel, Switzerland), 27, 4, 10.3390/molecules27041290, 35209079
Molecules (Basel, Switzerland), 27, 4, 10.3390/molecules27041290, 35209079
3D air-liquid interface culture of Cystic Fibrosis bronchial epithelia, macrophages and P. aeruginosa to assess host-pathogen interaction and drug efficacy
Publication
Montefusco C,
Montefusco-Pereira C
(2020)
Book, 10.22028/D291-31815
Book, 10.22028/D291-31815
Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
Publication
Park Y,
Meyer M,
Müller R,
Herrmann J
(2023)
International journal of molecular sciences, 24, 12, 10.3390/ijms241210076, 37373226
International journal of molecular sciences, 24, 12, 10.3390/ijms241210076, 37373226
Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos
Publication
Fries F,
Kany A,
Rasheed S,
Hirsch A,
Müller R,
Herrmann J
(2023)
International journal of molecular sciences, 24, 16, 10.3390/ijms241612791
International journal of molecular sciences, 24, 16, 10.3390/ijms241612791