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Targeting the Energy-Coupling Factor Transporters: A Novel Antibiotic Drug Target in Streptococcus pneumoniae
Publication
Diamanti E,
Cremers A,
Li Y,
Exapicheidou I,
Baumann C,
Gibson P,
Shams A,
Martin L,
Becker R,
Setyawati I,
Zeimetz L,
Haupenthal J,
Witschel M,
Slotboom D,
Herrmann J,
Rox K,
Hamed M,
Veening J,
Hirsch A
(2026)
Journal of medicinal chemistry, 69, 12, 14054-14068, 10.1021/acs.jmedchem.5c03638, 42284150
Journal of medicinal chemistry, 69, 12, 14054-14068, 10.1021/acs.jmedchem.5c03638, 42284150
DVD-IgG1 antibody-drug conjugates: Expanding the landscape of targeted cancer therapy
Publication
Kiefer A,
Steele A,
Rader C,
Shen B
(2026)
Current opinion in chemical biology, 92, 10.1016/j.cbpa.2026.102653, 41734646
Current opinion in chemical biology, 92, 10.1016/j.cbpa.2026.102653, 41734646
Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa
Publication
Meiers J,
Zahorska E,
Röhrig T,
Hauck D,
Wagner S,
Titz A
(2020)
Journal of medicinal chemistry, 63, 20, 11707-11724, 10.1021/acs.jmedchem.0c00856, 32924479
Journal of medicinal chemistry, 63, 20, 11707-11724, 10.1021/acs.jmedchem.0c00856, 32924479
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1
Publication
van der Vlag R,
Guo H,
Hapko U,
Eleftheriadis N,
Monjas L,
Dekker F,
Hirsch A
(2019)
European journal of medicinal chemistry, 174, 45-55, 10.1016/j.ejmech.2019.04.021, 31026746
European journal of medicinal chemistry, 174, 45-55, 10.1016/j.ejmech.2019.04.021, 31026746
Epistatic Interactions in NS5A of Hepatitis C Virus Suggest Drug Resistance Mechanisms
Publication
Knops E,
Sierra S,
Kalaghatgi P,
Heger E,
Kaiser R,
Kalinina O
(2018)
Genes, 9, 7, 10.3390/genes9070343, 29986475
Genes, 9, 7, 10.3390/genes9070343, 29986475
Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections
Publication
Calvert M,
Jumde V,
Titz A
(2018)
Beilstein journal of organic chemistry, 14, 2607-2617, 10.3762/bjoc.14.239, 30410623
Beilstein journal of organic chemistry, 14, 2607-2617, 10.3762/bjoc.14.239, 30410623
The role of mucus on drug transport and its potential to affect therapeutic outcomes
Publication
Murgia X,
Loretz B,
Hartwig O,
Hittinger M,
Lehr C
(2018)
Advanced Drug Delivery Reviews, 124, 82-97, 10.1016/j.addr.2017.10.009, 29106910
Advanced Drug Delivery Reviews, 124, 82-97, 10.1016/j.addr.2017.10.009, 29106910
Raman microscopy for cellular investigations--From single cell imaging to drug carrier uptake visualization
Publication
Kann B,
Offerhaus H,
Windbergs M,
Otto C
(2015)
Advanced Drug Delivery Reviews, 89, 71-90, 10.1016/j.addr.2015.02.006, 25728764
Advanced Drug Delivery Reviews, 89, 71-90, 10.1016/j.addr.2015.02.006, 25728764
The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets
Publication
Hirsch A,
Diederich F
(2008)
CHIMIA, 62, 4, 226-230, 10.2533/chimia.2008.226
CHIMIA, 62, 4, 226-230, 10.2533/chimia.2008.226
Fragment Based Drug Discovery by Microscale Thermophoresis Targeting Klebsiella pneumoniae and Escherichia coli IspE
Publication
Walsh D,
Willocx D,
Hamid R,
Hamed M,
Hirsch A
(2025)
Drug design, development and therapy, 19, 11345-11353, 10.2147/DDDT.S538771, 41439264
Drug design, development and therapy, 19, 11345-11353, 10.2147/DDDT.S538771, 41439264