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Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa
Publication
Meiers J,
Zahorska E,
Röhrig T,
Hauck D,
Wagner S,
Titz A
(2020)
Journal of medicinal chemistry, 63, 20, 11707-11724, 10.1021/acs.jmedchem.0c00856, 32924479
Journal of medicinal chemistry, 63, 20, 11707-11724, 10.1021/acs.jmedchem.0c00856, 32924479
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1
Publication
van der Vlag R,
Guo H,
Hapko U,
Eleftheriadis N,
Monjas L,
Dekker F,
Hirsch A
(2019)
European journal of medicinal chemistry, 174, 45-55, 10.1016/j.ejmech.2019.04.021, 31026746
European journal of medicinal chemistry, 174, 45-55, 10.1016/j.ejmech.2019.04.021, 31026746
Design of Poly-Catechol Biodynamers for Potentiation of Antibiotic Efficacy against Drug-Resistant Bacteria
Publication
Zeroug-Metz L,
Shehu K,
Bassil J,
Podlecki J,
Sonntag P,
Koch M,
Christoulaki A,
Buhler E,
Hirsch A,
Kraegeloh A,
Schneider M,
Lee S
(2026)
Biomacromolecules, 27, 3, 1949-1968, 10.1021/acs.biomac.5c02130, 41730198
Biomacromolecules, 27, 3, 1949-1968, 10.1021/acs.biomac.5c02130, 41730198
DVD-IgG1 antibody-drug conjugates: Expanding the landscape of targeted cancer therapy
Publication
Kiefer A,
Steele A,
Rader C,
Shen B
(2026)
Current opinion in chemical biology, 92, 10.1016/j.cbpa.2026.102653, 41734646
Current opinion in chemical biology, 92, 10.1016/j.cbpa.2026.102653, 41734646
The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets
Publication
Hirsch A,
Diederich F
(2008)
CHIMIA, 62, 4, 226-230, 10.2533/chimia.2008.226
CHIMIA, 62, 4, 226-230, 10.2533/chimia.2008.226
Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization
Publication
Fittler H,
Avrutina O,
Glotzbach B,
Empting M,
Kolmar H
(2013)
Org. Biomol. Chem., 11, 11, 1848-57, 10.1039/c3ob27469a, 23361403
Org. Biomol. Chem., 11, 11, 1848-57, 10.1039/c3ob27469a, 23361403
Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery**
Publication
Afanasenko A,
Wu X,
Santi A,
Elgaher W,
Kany A,
Shafiei R,
Schulze M,
Schulz T,
Haupenthal J,
Hirsch A,
Barta K
(2024)
Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 136, 4, 10.1002/ange.202308131
Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 136, 4, 10.1002/ange.202308131
Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery
Publication
Afanasenko A,
Wu X,
Santi A,
Elgaher W,
Kany A,
Shafiei R,
Schulze M,
Schulz T,
Haupenthal J,
Hirsch A,
Barta K
(2023)
Angew. Chem. Int. Ed., 10.1002/anie.202308131, 37840425
Angew. Chem. Int. Ed., 10.1002/anie.202308131, 37840425
Thermoresponsive cholesteric liquid-crystal systems doped with terpenoids as drug delivery systems for skin applications
Publication
Nesterkina M,
Vashchenko O,
Vashchenko P,
Lisetski L,
Kravchenko I,
Hirsch A,
Lehr C
(2023)
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 10.1016/j.ejpb.2023.09.002, 37669726
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 10.1016/j.ejpb.2023.09.002, 37669726
Simulated Tempering-Enhanced Umbrella Sampling Improves Convergence of Free Energy Calculations of Drug Membrane Permeation
Publication
Sousa C,
Becker R,
Lehr C,
Kalinina O,
Hub J
(2023)
Journal of chemical theory and computation, 19, 6, 1898-1907, 10.1021/acs.jctc.2c01162, 36853966
Journal of chemical theory and computation, 19, 6, 1898-1907, 10.1021/acs.jctc.2c01162, 36853966