Researcher in Laboratory © HIPS

Carsten Seyfert


Carsten Seyfert studied molecular biology at the University of Basel from September 2014 to February 2019 and got his Bachelor and Master degree in Molecular biology at the Biocenter of the University of Basel. During his Master studies, he was employed full-time from September 2017 to February 2019 in the research group of Prof. Christoph Dehio in the focal area of infection biology. During this time he established a nanobody expression platform to characterize Bartonella effector proteins (Beps) resulting in the elucidation of first full-length structure of a Bep. After this study time in Basel, he went to Heidelberg for an internship at Octapharma Biopharmaceuticals and worked in the Cell line development and engineering group. Since January 2020, he is working on his PhD project in the Microbial Natural Products department of the HIPS under the supervision of Prof. Rolf Müller. His research interest is the genetic engineering of microbial secondary metabolite biosynthetic pathways to produce new antibiotics.


Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering

Seyfert C, Porten C, Yuan B, Deckarm S, Panter F, Bader C, Coetzee J, Deschner F, Tehrani K, Higgins P, …, Herrmann J, Müller R (2022)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214094


Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

Groß S, Panter F, Pogorevc D, Seyfert C, Deckarm S, Bader C, Herrmann J, Müller R (2021)

Chem. Sci. 12 (35): 11882-11893DOI: 10.1039/d1sc02725e