Dr Florian Hubrich
About
Florian Hubrich studied chemistry and biology at the University of Freiburg. Following his Staatsexamen, he started a PhD in chemical biology supervised by Jennifer Andexer and Michael Müller at the Institute of Pharmaceutical Sciences in Freiburg and graduated at the end of 2014. Afterwards, Florian Hubrich moved to Switzerland and worked for the Bachem AG, a world leading company for peptide drug manufacturing, as project chemist for analytical method development and group leader for in-process control. In 2019, he returned to academia and joined Jörn Piel’s lab as a postdoctoral researcher at the ETH Zurich. For his postdoctoral research, he studied the biosynthesis of ribosomally synthesized and post-translational modified peptides (RiPPs). In 2024, Hubrich started his junior research group at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) and the Saarland University.
Florian Hubrich’s research interest is the expansion of the natural product chemical space at the interface of primary and secondary metabolism. His group will focus on the bioengineering of antimicrobial lipopeptides to understand the effect of distinct lipid moieties on bioactivity and therapeutic properties.
2024
Ribosomal peptides with polycyclic isoprenoid moieties
Hubrich F, Kandy S, Chepkirui C, Padhi C, Mordhorst S, Moosmann P, Zhu T, Gugger M, Chekan J, Piel J (2024)
Chem 10 (10): 3224-3242
Ribosomal peptides with polycyclic isoprenoid moieties
Hubrich F, Kandy S, Chepkirui C, Padhi C, Mordhorst S, Moosmann P, Zhu T, Gugger M, Chekan J, Piel J (2024)
Chem 10 (10): 3224-3242
2022
Biosynthesis of Menaquinone in E. coli: Identification of an Elusive Isomer of SEPHCHC
Fries A, Mazzaferro L, Bisel P, Hubrich F, Andexer J, Müller M (2022)
ChemBioChem 23 (18)DOI: 10.1002/cbic.202200181
Widespread microbial utilization of ribosomal β-amino acid-containing peptides and proteins
Scott T, Verest M, Farnung J, Forneris C, Robinson S, Ji X, Hubrich F, Chepkirui C, Richter D, Huber S, …, Bode J, Piel J (2022)
Chem 8 (10): 2659-2677
Widespread microbial utilization of ribosomal β-amino acid-containing peptides and proteins
Scott T, Verest M, Farnung J, Forneris C, Robinson S, Ji X, Hubrich F, Chepkirui C, Richter D, Huber S, …, Bode J, Piel J (2022)
Chem 8 (10): 2659-2677
Biosynthetic potential of the global ocean microbiome
Paoli L, Ruscheweyh H, Forneris C, Hubrich F, Kautsar S, Bhushan A, Lotti A, Clayssen Q, Salazar G, Milanese A, …, Piel J, Sunagawa S (2022)
Nature 607 (7917): 111-118DOI: 10.1038/s41586-022-04862-3
Ribosomally derived lipopeptides containing distinct fatty acyl moieties
Hubrich F, Bösch N, Chepkirui C, Morinaka B, Rust M, Gugger M, Robinson S, Vagstad A, Piel J (2022)
Proc. Natl. Acad. Sci. U.S.A. 119 (3)DOI: 10.1073/pnas.2113120119
2021
Uncovering Novel Peptide Chemistry from Bacterial Natural Products
Hubrich F, Lotti A, Scott T, Piel J (2021)
Chimia (Aarau) 75 (6): 543-547DOI: 10.2533/chimia.2021.543
Chorismate- and isochorismate converting enzymes: versatile catalysts acting on an important metabolic node
Hubrich F, Müller M, Andexer J (2021)
Chem. Commun. (Camb) 57 (20): 2441-2463DOI: 10.1039/d0cc08078k
2019
Chorismatases - the family is growing
Grüninger M, Buchholz P, Mordhorst S, Strack P, Müller M, Hubrich F, Pleiss J, Andexer J (2019)
Org. Biomol. Chem. 17 (8): 2092-2098DOI: 10.1039/c8ob03038c
2015
Chorismatase Mechanisms Reveal Fundamentally Different Types of Reaction in a Single Conserved Protein Fold
Hubrich F, Juneja P, Müller M, Diederichs K, Welte W, Andexer J (2015)
J. Am. Chem. Soc. 137 (34): 11032-7DOI: 10.1021/jacs.5b05559
2014
Mechanistic implications for the chorismatase FkbO based on the crystal structure
Juneja P, Hubrich F, Diederichs K, Welte W, Andexer J (2014)
J. Mol. Biol. 426 (1): 105-15DOI: 10.1016/j.jmb.2013.09.006
In vitro production and purification of isochorismate using a two-enzyme cascade
Hubrich F, Müller M, Andexer J (2014)
J. Biotechnol. 191: 93-8DOI: 10.1016/j.jbiotec.2014.06.003
2013
Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases
Hubrich F, Mordhorst S, Andexer J (2013)
Bioorg. Med. Chem. Lett. 23 (5): 1477-81DOI: 10.1016/j.bmcl.2012.12.059
2011
Engineering the respiratory complex I to energy-converting NADPH:ubiquinone oxidoreductase
Morina K, Schulte M, Hubrich F, Dörner K, Steimle S, Stolpe S, Friedrich T (2011)
J. Biol. Chem. 286 (40): 34627-34DOI: 10.1074/jbc.M111.274571