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Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli
Publication
Müller R,
Risch T,
Kolling D,
Mostert D,
Seedorf T,
Heimann D,
Kohnhäuser D,
Deschner F,
Fries F,
Solga D,
Hilgers J,
Dastbaz J,
Hirsch A,
Brönstrup M,
Kirschning A,
Herrmann J,
Sieber S
(2024)
Book, 10.21203/rs.3.rs-3751821/v1
Book, 10.21203/rs.3.rs-3751821/v1
Development and evaluation of 2,4-disubstituted-5-aryl pyrimidine derivatives as antibacterial agents
Publication
Khalifa H,
Rasheed S,
Haupenthal J,
Herrmann J,
Mandour Y,
Abadi A,
Engel M,
Müller R,
Hirsch A,
Abdel-Halim* M,
Hamed* M
(2024)
Archiv der Pharmazie, 10.1002/ardp.202300656, 38304944
Archiv der Pharmazie, 10.1002/ardp.202300656, 38304944
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections
Publication
Konstantinovic J,
Kany A,
Alhayek A,
Abdelsamie A,
Sikandar A,
Voos K,
Yao Y,
Andreas A,
Shafiei R,
Loretz B,
Schönauer E,
Bals R,
Brandstetter H,
Hartmann R,
Ducho C,
Lehr C,
Beisswenger C,
Müller R,
Rox K,
Haupenthal J,
Hirsch A
(2023)
ACS Cent. Sci., 9, 12, 2205-2215, 10.1021/acscentsci.3c01102, 38161367
ACS Cent. Sci., 9, 12, 2205-2215, 10.1021/acscentsci.3c01102, 38161367
Fighting antibiotic resistance-strategies and (pre)clinical developments to find new antibacterials
Publication
Walesch S,
Birkelbach J,
Jézéquel G,
Haeckl F,
Hegemann J,
Hesterkamp T,
Hirsch A,
Hammann P,
Müller R
(2023)
EMBO reports, 24, 1, 10.15252/embr.202256033, 36533629
EMBO reports, 24, 1, 10.15252/embr.202256033, 36533629
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins
Publication
Gao Y,
Walt C,
Bader C,
Müller R
(2023)
ACS chemical biology, 18, 4, 924-932, 10.1021/acschembio.3c00063, 37014749
ACS chemical biology, 18, 4, 924-932, 10.1021/acschembio.3c00063, 37014749
An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability
Publication
Richter R,
Kamal M,
Koch M,
Niebuur B,
Huber A,
Goes A,
Volz C,
Vergalli J,
Kraus T,
Müller R,
Schneider-Daum N,
Fuhrmann G,
Pagès J,
Lehr C
(2022)
Advanced healthcare materials, 11, 5, 10.1002/adhm.202101180, 34614289
Advanced healthcare materials, 11, 5, 10.1002/adhm.202101180, 34614289
PLSDB: advancing a comprehensive database of bacterial plasmids
Publication
Schmartz G,
Hartung A,
Hirsch P,
Kern F,
Fehlmann T,
Müller R,
Keller A
(2022)
Nucleic Acids Res, 50, D1, 273-, 10.1093/nar/gkab1111, 34850116
Nucleic Acids Res, 50, D1, 273-, 10.1093/nar/gkab1111, 34850116
Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering
Publication
Seyfert C,
Porten C,
Yuan B,
Deckarm S,
Panter F,
Bader C,
Coetzee J,
Deschner F,
Tehrani K,
Higgins P,
Seifert H,
Marlovits T,
Herrmann J,
Müller R
(2022)
Angewandte Chemie (International ed. in English), 10.1002/anie.202214094, 36308277
Angewandte Chemie (International ed. in English), 10.1002/anie.202214094, 36308277
Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA-Virus Inhibitors
Publication
Haack P,
Harmrolfs K,
Bader C,
Garcia R,
Gunesch A,
Haid S,
Popoff A,
Voltz A,
Kim H,
Bartenschlager R,
Pietschmann T,
Müller R
(2022)
Angewandte Chemie (International ed. in English), 10.1002/anie.202212946, 36208117
Angewandte Chemie (International ed. in English), 10.1002/anie.202212946, 36208117
Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA
Publication
Fathalla R,
Fröhner W,
Bader C,
Fischer P,
Dahlem C,
Chatterjee D,
Mathea S,
Kiemer A,
Arthanari H,
Müller R,
Abdel-Halim M,
Ducho C,
Engel M
(2022)
Journal of medicinal chemistry, 10.1021/acs.jmedchem.2c01275, 36269107
Journal of medicinal chemistry, 10.1021/acs.jmedchem.2c01275, 36269107