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A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin
Publication
Wenzel S,
Bode H,
Kochems I,
Müller R
(2008)
ChemBioChem, 9, 16, 2711-2721, 10.1002/cbic.200800456, 18972512
ChemBioChem, 9, 16, 2711-2721, 10.1002/cbic.200800456, 18972512
Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase
Publication
Petkovic H,
Sandmann A,
Challis I,
Hecht H,
Silakowski B,
Low L,
Beeston N,
Kuscer E,
Garcia-Bernardo J,
Leadlay P,
Kendrew S,
Wilkinson B,
Müller R
(2008)
Org. Biomol. Chem., 6, 3, 500-506, 10.1039/b714804f
Org. Biomol. Chem., 6, 3, 500-506, 10.1039/b714804f
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using Red/ET recombineering
Publication
Binz T,
Wenzel S,
Schnell H,
Bechthold A,
Müller R
(2008)
ChemBioChem, 9, 3, 447-454, 10.1002/cbic.200700549
ChemBioChem, 9, 3, 447-454, 10.1002/cbic.200700549
From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes
Publication
Frank B,
Wenzel S,
Bode H,
Scharfe M,
Blöcker H,
Müller R
(2007)
J. Mol. Biol., 374, 1, 24-38, 10.1016/j.jmb.2007.09.015
J. Mol. Biol., 374, 1, 24-38, 10.1016/j.jmb.2007.09.015
Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin
Publication
Elnakady Y,
Rohde M,
Sasse F,
Backes C,
Keller A,
Lenhof H,
Weissman K,
Müller R
(2007)
ChemBioChem, 8, 11, 1261-1272, 10.1002/cbic.200700050
ChemBioChem, 8, 11, 1261-1272, 10.1002/cbic.200700050
Biosynthesis of the isoprenoid moieties of furanonaphthoquinone I and endophenazine A in Streptomyces cinnamonensis DSM 1042
Publication
Bringmann G,
Haagen Y,
Gulder T,
Gulder T,
Heide L
(2007)
J. Org. Chem., 72, 11, 4198-204, 10.1021/jo0703404, 17474781
J. Org. Chem., 72, 11, 4198-204, 10.1021/jo0703404, 17474781
A type II polyketide synthase from the gram-negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis
Publication
Sandmann A,
Dickschat J,
Jenke-Kodama H,
Kunze B,
Dittmann E,
Müller R
(2007)
Angew. Chem. Int. Ed. Engl., 46, 15, 2712-2716, 10.1002/anie.200603513, 17335090
Angew. Chem. Int. Ed. Engl., 46, 15, 2712-2716, 10.1002/anie.200603513, 17335090
Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B
Publication
Bode H,
Meiser P,
Klefisch T,
Cortina N,
Krug D,
Göhring A,
Schwär G,
Mahmud T,
Elnakady Y,
Müller R
(2007)
ChemBioChem, 8, 17, 2139-2144, 10.1002/cbic.200700401
ChemBioChem, 8, 17, 2139-2144, 10.1002/cbic.200700401
SorF, a glycosyltransferase with promiscuous donor substrate specificity in vitro
Publication
Kopp M,
Rupprath C,
Irschik H,
Bechthold A,
Elling L,
Müller R
(2007)
ChemBioChem, 8, 7, 813-819, 10.1002/cbic.200700024
ChemBioChem, 8, 7, 813-819, 10.1002/cbic.200700024
Mutational analysis of the myxovirescin biosynthetic gene cluster reveals novel insights into the functional elaboration of polyketide backbones
Publication
Simunovic V,
Müller R
(2007)
ChemBioChem, 8, 11, 1273-1280, 10.1002/cbic.200700153, 17583882
ChemBioChem, 8, 11, 1273-1280, 10.1002/cbic.200700153, 17583882