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Jun Prof Dr Gregor Fuhrmann

About

Gregor studied Pharmacy in Berlin and received his PhD from the Swiss Federal Institute of Technology (EHT) in 2013. After a Marie Curie Postdoctoral Fellowship at Imperial College London, he initiated the Biogenic Nanotherapeutics group (BION) at HIPS in 2016. His research interests are extracellular vesicles from human and bacterial cells and their potential role during infection therapy.


2022

Themed issue: Extracellular vesicles in drug delivery and bioengineering

Fuhrmann G, Lehr C, Schiffelers R (2022)

Advanced Drug Delivery Reviews 181DOI: 10.1016/j.addr.2021.114073

An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability

Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, …, Pagès J, Lehr C (2022)

Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101180

Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization

Mehanny M, Boese A, Bornamehr B, Hoppstädter J, Presser V, Kiemer A, Lehr C, Fuhrmann G (2022)

International journal of pharmaceutics 621DOI: 10.1016/j.ijpharm.2022.121794

Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase

Mehanny M, Kroniger T, Koch M, Hoppstädter J, Becher D, Kiemer A, Lehr C, Fuhrmann G (2022)

Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101151

Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor

Drost M, Diamanti E, Fuhrmann K, Goes A, Shams A, Haupenthal J, Koch M, Hirsch A, Fuhrmann G (2022)

Pharmaceutics 14 (1)DOI: 10.3390/pharmaceutics14010004

2021

Extracellular vesicles as antigen carriers for novel vaccination avenues

Mehanny M, Lehr C, Fuhrmann G (2021)

Advanced Drug Delivery Reviews 173: 164-180DOI: 10.1016/j.addr.2021.03.016

Stimulation of Probiotic Bacteria Induces Release of Membrane Vesicles with Augmented Anti-inflammatory Activity

Müller L, Kuhn T, Koch M, Fuhrmann G (2021)

ACS Appl. Bio Mater.DOI: 10.1021/acsabm.0c01136

2020

Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections

Goes A, Lapuhs P, Kuhn T, Schulz E, Richter R, Panter F, Dahlem C, Koch M, Garcia R, Kiemer A, Müller R, Fuhrmann G (2020)

Cells 9 (1)DOI: 10.3390/cells9010194

Editorial: Mechanisms of Prokaryotic Predation

Whitworth D, Jurkevitch E, Pérez J, Fuhrmann G, Koval S (2020)

Frontiers in microbiology 11DOI: 10.3389/fmicb.2020.02071

Probiomimetics-Novel Lactobacillus-Mimicking Microparticles Show Anti-Inflammatory and Barrier-Protecting Effects in Gastrointestinal Models

Kuhn T, Koch M, Fuhrmann G (2020)

Small (Weinheim an der Bergstrasse, Germany) 16 (40)DOI: 10.1002/smll.202003158

Diffusion and transport of extracellular vesicles

Fuhrmann G (2020)

Nature Nanotechnology 15 (3): 168-169DOI: 10.1038/s41565-020-0651-3

Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility

Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano C, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr C, Russo L (2020)

European Journal of Pharmaceutics and Biopharmaceutics 149: 12-20DOI: 10.1016/j.ejpb.2020.01.013

Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices

Zivko C, Fuhrmann G, Luciani P (2020)

Biochimica et Biophysica Acta - General Subjects 1865 (4)DOI: 10.1016/j.bbagen.2020.129559

Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release

Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)

Frontiers in immunology 11DOI: 10.3389/fimmu.2020.00080

Hot EVs – how temperature affects extracellular vesicles

Schulz E, Karagianni A, Koch M, Fuhrmann G (2020)

European Journal of Pharmaceutics and Biopharmaceutics 146: 55-63DOI: 10.1016/j.ejpb.2019.11.010

2019

Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide

Hoppstädter J, Dembek A, Linnenberger R, Dahlem C, Barghash A, Fecher-Trost C, Fuhrmann G, Koch M, Kraegeloh A, Huwer H, Kiemer A (2019)

Front. Immunol. 10DOI: 10.3389/fimmu.2019.01634

Engineering strategies for oral therapeutic enzymes to enhance their stability and activity

Lapuhs P, Fuhrmann G (2019)

Book 1148DOI: 10.1007/978-981-13-7709-9_8

Author Correction: Extracellular vesicles protect glucuronidase model enzymes during freeze-drying (Scientific Reports, (2018), 8, 1, (12377), 10.1038/s41598-018-30786-y)

Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2019)

Scientific Reports 9 (1)DOI: 10.1038/s41598-019-48221-1

Corrigendum to biocompatible bacteria-derived vesicles show inherent antimicrobial activity (Journal of Controlled Release (2018) 290 (46–55), (S0168365918305698) (10.1016/j.jconrel.2018.09.030))

Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2019)

Journal of Controlled Release 293: 155-157DOI: 10.1016/j.jconrel.2018.11.027

Extracellular Vesicles—Connecting Kingdoms

Woith E, Fuhrmann G, Melzig M (2019)

International journal of molecular sciences 20 (22)DOI: 10.3390/ijms20225695

Evaluation of the Storage Stability of Extracellular Vesicles

Richter M, Fuhrmann K, Fuhrmann G (2019)

Journal of visualized experiments : JoVE (147)DOI: 10.3791/59584

2018

Luminal coating of the intestine

Fuhrmann G (2018)

Nature Materials 17 (9): 754-755DOI: 10.1038/s41563-018-0143-0

Extracellular vesicles protect glucuronidase model enzymes during freeze-drying

Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2018)

Scientific Reports 8 (1)DOI: 10.1038/s41598-018-30786-y

Biocompatible bacteria-derived vesicles show inherent antimicrobial activity

Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2018)

Journal of Controlled Release 290: 46-55DOI: 10.1016/j.jconrel.2018.09.030

Biogenic and Biomimetic Carriers as Versatile Transporters To Treat Infections

Goes A, Fuhrmann G (2018)

ACS infectious diseases 4 (6): 881-892DOI: 10.1021/acsinfecdis.8b00030

Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy

Fuhrmann G, Chandrawati R, Parmar P, Keane T, Maynard S, Bertazzo S, Stevens M (2018)

Advanced materials (Deerfield Beach, Fla.) 30 (15)DOI: 10.1002/adma.201706616

2017

Recent advances in oral delivery of macromolecular drugs and benefits of polymer conjugation

Kathrin Fuhrmann G (2017)

Current Opinion in Colloid & Interface Science 31: 67-74DOI: 10.1016/j.cocis.2017.07.002

Extracellular vesicles - A promising avenue for the detection and treatment of infectious diseases?

Fuhrmann G, Neuer A, Herrmann I (2017)

Eur J Pharm Biopharm 118: 56-61DOI: 10.1016/j.ejpb.2017.04.005

2016

Erratum: Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates (Nature Chemistry (2013) 5 (582-589))

Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Yu H, Zhang B, Walde P, Schlüter A, Gauthier M, Leroux J (2016)

Nature chemistry 8 (3)DOI: 10.1038/nchem.2458

2015

Extracellular Stiffness Modulates the Expression of Functional Proteins and Growth Factors in Endothelial Cells

Santos L, Fuhrmann G, Juenet M, Amdursky N, Horejs C, Campagnolo P, Stevens M (2015)

Advanced healthcare materials 4 (14): 2056-2063DOI: 10.1002/adhm.201500338

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

Fuhrmann G, Serio A, Mazo M, Nair R, Stevens M (2015)

Journal of Controlled Release 205: 35-44DOI: 10.1016/j.jconrel.2014.11.029

Cell-derived vesicles for drug therapy and diagnostics

Fuhrmann G, Herrmann I, Stevens M (2015)

Nano Today 10 (3): 397-409DOI: 10.1016/j.nantod.2015.04.004

2013

Polymer-enzyme conjugates for oral drug delivery applications

Fuhrmann G, Gauthier M, Leroux J (2013)

Chimia 67 (9)DOI: 10.2533/chimia.2013.685

Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates

Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Yu H, Zhang B, Walde P, Schlüter A, Gauthier M, Leroux J (2013)

Nature chemistry 5 (7): 582-589DOI: 10.1038/nchem.1675

Celiac disease: A challenging disease for pharmaceutical scientists

Matoori S, Fuhrmann G, Leroux J (2013)

Pharmaceutical research 30 (3): 619-626DOI: 10.1007/s11095-012-0951-x

2012

The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues

Pinier M, Fuhrmann G, Galipeau H, Rivard N, Murray J, David C, Drasarova H, Tuckova L, Leroux J, Verdu E (2012)

Gastroenterology 142 (2): 316-325DOI: 10.1053/j.gastro.2011.10.038

Erratum: In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 22 (9032-9037) DOI: 10.1073/pnas. 1100285108)

Fuhrmann G, Leroux J (2012)

Proceedings of the National Academy of Sciences of the United States of America 109 (42)DOI: 10.1073/pnas.1216389109

2011

Erratum: Prevention measures and exploratory pharmacological treatments of celiac disease (American Journal of Gastroenterology (2010) 105 (2551-2561) DOI: 10.1038/ ajg.2010.372)

Pinier M, Fuhrmann G, Verdu E, Leroux J (2011)

American Journal of Gastroenterology 106 (2)DOI: 10.1038/ajg.2010.454

In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract

Fuhrmann G, Leroux J (2011)

Proceedings of the National Academy of Sciences of the United States of America 108 (22): 9032-9037DOI: 10.1073/pnas.1100285108

2010

In vitro evaluation of the stability of proline-specific endopeptidases under simulated gastrointestinal conditions

Fuhrmann G, Leroux J (2010)

J Control Release 148 (1): 37-39DOI: 10.1016/j.jconrel.2010.07.046

Prevention measures and exploratory pharmacological treatments of celiac disease

Pinier M, Fuhrmann G, Verdu E, Leroux J (2010)

American Journal of Gastroenterology 105 (12): 2551-2561DOI: 10.1038/ajg.2010.372

Tyrosine-based rivastigmine-loaded organogels in the treatment of Alzheimer's disease

Bastiat G, Plourde F, Motulsky A, Furtos A, Dumont Y, Quirion R, Fuhrmann G, Leroux J (2010)

Biomaterials 31 (23): 6031-6038DOI: 10.1016/j.biomaterials.2010.04.009