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Jun. Prof. Dr. Gregor Fuhrmann
Über
Gregor studierte Pharmazie in Berlin und promovierte 2013 an der Eidgenössischen Technischen Hochschule (EHT). Nach einem Marie-Curie Postdoc-Aufenthalt am Imperial College London initiierte er 2016 seine Nachwuchsgruppe Biogene Nanotherapeutika (BION) am HIPS. Seine Forschungsinteressen sind extrazelluläre Vesikel von menschlichen und bakteriellen Zellen und ihre mögliche Rolle bei Infektionen.Gregor studierte Pharmazie in Berlin und promovierte 2013 an der Eidgenössischen Technischen Hochschule (EHT). Nach einem Marie-Curie Postdoc-Aufenthalt am Imperial College London initiierte er 2016 seine Nachwuchsgruppe Biogene Nanotherapeutika (BION) am HIPS. Seine Forschungsinteressen sind extrazelluläre Vesikel von menschlichen und bakteriellen Zellen und ihre mögliche Rolle bei Infektionen.
2024
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
Mashayekhi V, Schomisch A, Rasheed S, Aparicio-Puerta E, Risch T, Yildiz D, Koch M, Both S, Ludwig N, Legroux T, …, Hoppstädter J, Kiemer A (2024)
Cell communication and signaling : CCS 22 (1)DOI: 10.1186/s12964-024-01701-y
2023
Cell-Derived Vesicles for Antibiotic Delivery-Understanding the Challenges of a Biogenic Carrier System
Heinrich E, Hartwig O, Walt C, Kardani A, Koch M, Jahromi L, Hoppstädter J, Kiemer A, Loretz B, Lehr C, Fuhrmann G (2023)
Small (Weinheim an der Bergstrasse, Germany) 19 (25)DOI: 10.1002/smll.202207479
Ageing-associated small RNA cargo of extracellular vesicles
Kern F, Kuhn T, Ludwig N, Simon M, Gröger L, Fabis N, Aparicio-Puerta E, Salhab A, Fehlmann T, Hahn O, …, Laschke M, Keller A (2023)
RNA biology 20 (1): 482-494DOI: 10.1080/15476286.2023.2234713
2022
The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation
Lapuhs P, Heinrich E, Garcia R, Goes A, Frank N, Bollenbach L, Stibane V, Kuhn T, Koch M, Kiemer A, …, Fuhrmann K, Fuhrmann G (2022)
NanoscaleDOI: 10.1039/d2nr02743g
Themed issue: Extracellular vesicles in drug delivery and bioengineering
Fuhrmann G, Lehr C, Schiffelers R (2022)
Advanced Drug Delivery Reviews 181DOI: 10.1016/j.addr.2021.114073
An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability
Richter R, Kamal M, Koch M, Niebuur B, Huber A, Goes A, Volz C, Vergalli J, Kraus T, Müller R, …, Pagès J, Lehr C (2022)
Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101180
Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization
Mehanny M, Boese A, Bornamehr B, Hoppstädter J, Presser V, Kiemer A, Lehr C, Fuhrmann G (2022)
International journal of pharmaceutics 621DOI: 10.1016/j.ijpharm.2022.121794
Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase
Mehanny M, Kroniger T, Koch M, Hoppstädter J, Becher D, Kiemer A, Lehr C, Fuhrmann G (2022)
Advanced healthcare materials 11 (5)DOI: 10.1002/adhm.202101151
Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor
Drost M, Diamanti E, Fuhrmann K, Goes A, Shams A, Haupenthal J, Koch M, Hirsch A, Fuhrmann G (2022)
Pharmaceutics 14 (1)DOI: 10.3390/pharmaceutics14010004
2021
Extracellular vesicles as antigen carriers for novel vaccination avenues
Mehanny M, Lehr C, Fuhrmann G (2021)
Advanced Drug Delivery Reviews 173: 164-180DOI: 10.1016/j.addr.2021.03.016
Stimulation of Probiotic Bacteria Induces Release of Membrane Vesicles with Augmented Anti-inflammatory Activity
Müller L, Kuhn T, Koch M, Fuhrmann G (2021)
ACS Appl. Bio Mater.DOI: 10.1021/acsabm.0c01136
2020
Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections
Goes A, Lapuhs P, Kuhn T, Schulz E, Richter R, Panter F, Dahlem C, Koch M, Garcia R, Kiemer A, Müller R, Fuhrmann G (2020)
Cells 9 (1)DOI: 10.3390/cells9010194
Editorial: Mechanisms of Prokaryotic Predation
Whitworth D, Jurkevitch E, Pérez J, Fuhrmann G, Koval S (2020)
Frontiers in microbiology 11DOI: 10.3389/fmicb.2020.02071
Probiomimetics-Novel Lactobacillus-Mimicking Microparticles Show Anti-Inflammatory and Barrier-Protecting Effects in Gastrointestinal Models
Kuhn T, Koch M, Fuhrmann G (2020)
Small (Weinheim an der Bergstrasse, Germany) 16 (40)DOI: 10.1002/smll.202003158
Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility
Montefusco-Pereira C, Formicola B, Goes A, Re F, Marrano C, Mantegazza F, Carvalho-Wodarz C, Fuhrmann G, Caneva E, Nicotra F, Lehr C, Russo L (2020)
European Journal of Pharmaceutics and Biopharmaceutics 149: 12-20DOI: 10.1016/j.ejpb.2020.01.013
Liver-derived extracellular vesicles: A cell by cell overview to isolation and characterization practices
Zivko C, Fuhrmann G, Luciani P (2020)
Biochimica et Biophysica Acta - General Subjects 1865 (4)DOI: 10.1016/j.bbagen.2020.129559
Diffusion and transport of extracellular vesicles
Fuhrmann G (2020)
Nature Nanotechnology 15 (3): 168-169DOI: 10.1038/s41565-020-0651-3
Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release
Mehanny M, Koch M, Lehr C, Fuhrmann G (2020)
Frontiers in immunology 11DOI: 10.3389/fimmu.2020.00080
Hot EVs – how temperature affects extracellular vesicles
Schulz E, Karagianni A, Koch M, Fuhrmann G (2020)
European Journal of Pharmaceutics and Biopharmaceutics 146: 55-63DOI: 10.1016/j.ejpb.2019.11.010
2019
Engineering strategies for oral therapeutic enzymes to enhance their stability and activity
Lapuhs P, Fuhrmann G (2019)
Book 1148DOI: 10.1007/978-981-13-7709-9_8
Author Correction: Extracellular vesicles protect glucuronidase model enzymes during freeze-drying (Scientific Reports, (2018), 8, 1, (12377), 10.1038/s41598-018-30786-y)
Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2019)
Scientific Reports 9 (1)DOI: 10.1038/s41598-019-48221-1
Corrigendum to biocompatible bacteria-derived vesicles show inherent antimicrobial activity (Journal of Controlled Release (2018) 290 (46–55), (S0168365918305698) (10.1016/j.jconrel.2018.09.030))
Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2019)
Journal of Controlled Release 293: 155-157DOI: 10.1016/j.jconrel.2018.11.027
Toll-Like Receptor 2 Release by Macrophages: An Anti-inflammatory Program Induced by Glucocorticoids and Lipopolysaccharide
Hoppstädter J, Dembek A, Linnenberger R, Dahlem C, Barghash A, Fecher-Trost C, Fuhrmann G, Koch M, Kraegeloh A, Huwer H, Kiemer A (2019)
Front. Immunol. 10DOI: 10.3389/fimmu.2019.01634
Extracellular Vesicles—Connecting Kingdoms
Woith E, Fuhrmann G, Melzig M (2019)
International journal of molecular sciences 20 (22)DOI: 10.3390/ijms20225695
Evaluation of the Storage Stability of Extracellular Vesicles
Richter M, Fuhrmann K, Fuhrmann G (2019)
Journal of visualized experiments : JoVE (147)DOI: 10.3791/59584
2018
Luminal coating of the intestine
Fuhrmann G (2018)
Nature Materials 17 (9): 754-755DOI: 10.1038/s41563-018-0143-0
Extracellular vesicles protect glucuronidase model enzymes during freeze-drying
Frank J, Richter M, Rossi C, Lehr C, Fuhrmann K, Fuhrmann G (2018)
Scientific Reports 8 (1)DOI: 10.1038/s41598-018-30786-y
Biocompatible bacteria-derived vesicles show inherent antimicrobial activity
Schulz E, Goes A, Garcia R, Panter F, Koch M, Müller R, Fuhrmann K, Fuhrmann G (2018)
Journal of Controlled Release 290: 46-55DOI: 10.1016/j.jconrel.2018.09.030
Biogenic and Biomimetic Carriers as Versatile Transporters To Treat Infections
Goes A, Fuhrmann G (2018)
ACS infectious diseases 4 (6): 881-892DOI: 10.1021/acsinfecdis.8b00030
Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy
Fuhrmann G, Chandrawati R, Parmar P, Keane T, Maynard S, Bertazzo S, Stevens M (2018)
Advanced materials (Deerfield Beach, Fla.) 30 (15)DOI: 10.1002/adma.201706616
2017
Recent advances in oral delivery of macromolecular drugs and benefits of polymer conjugation
Kathrin Fuhrmann G (2017)
Current Opinion in Colloid & Interface Science 31: 67-74DOI: 10.1016/j.cocis.2017.07.002
Extracellular vesicles - A promising avenue for the detection and treatment of infectious diseases?
Fuhrmann G, Neuer A, Herrmann I (2017)
Eur J Pharm Biopharm 118: 56-61DOI: 10.1016/j.ejpb.2017.04.005
2016
Erratum: Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates (Nature Chemistry (2013) 5 (582-589))
Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Yu H, Zhang B, Walde P, Schlüter A, Gauthier M, Leroux J (2016)
Nature chemistry 8 (3)DOI: 10.1038/nchem.2458
2015
Extracellular Stiffness Modulates the Expression of Functional Proteins and Growth Factors in Endothelial Cells
Santos L, Fuhrmann G, Juenet M, Amdursky N, Horejs C, Campagnolo P, Stevens M (2015)
Advanced healthcare materials 4 (14): 2056-2063DOI: 10.1002/adhm.201500338
Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins
Fuhrmann G, Serio A, Mazo M, Nair R, Stevens M (2015)
Journal of Controlled Release 205: 35-44DOI: 10.1016/j.jconrel.2014.11.029
Cell-derived vesicles for drug therapy and diagnostics
Fuhrmann G, Herrmann I, Stevens M (2015)
Nano Today 10 (3): 397-409DOI: 10.1016/j.nantod.2015.04.004
2013
Polymer-enzyme conjugates for oral drug delivery applications
Fuhrmann G, Gauthier M, Leroux J (2013)
Chimia 67 (9)DOI: 10.2533/chimia.2013.685
Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates
Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Yu H, Zhang B, Walde P, Schlüter A, Gauthier M, Leroux J (2013)
Nature chemistry 5 (7): 582-589DOI: 10.1038/nchem.1675
Celiac disease: A challenging disease for pharmaceutical scientists
Matoori S, Fuhrmann G, Leroux J (2013)
Pharmaceutical research 30 (3): 619-626DOI: 10.1007/s11095-012-0951-x
2012
The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues
Pinier M, Fuhrmann G, Galipeau H, Rivard N, Murray J, David C, Drasarova H, Tuckova L, Leroux J, Verdu E (2012)
Gastroenterology 142 (2): 316-325DOI: 10.1053/j.gastro.2011.10.038
Erratum: In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 22 (9032-9037) DOI: 10.1073/pnas. 1100285108)
Fuhrmann G, Leroux J (2012)
Proceedings of the National Academy of Sciences of the United States of America 109 (42)DOI: 10.1073/pnas.1216389109
2011
Erratum: Prevention measures and exploratory pharmacological treatments of celiac disease (American Journal of Gastroenterology (2010) 105 (2551-2561) DOI: 10.1038/ ajg.2010.372)
Pinier M, Fuhrmann G, Verdu E, Leroux J (2011)
American Journal of Gastroenterology 106 (2)DOI: 10.1038/ajg.2010.454
In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract
Fuhrmann G, Leroux J (2011)
Proceedings of the National Academy of Sciences of the United States of America 108 (22): 9032-9037DOI: 10.1073/pnas.1100285108
2010
In vitro evaluation of the stability of proline-specific endopeptidases under simulated gastrointestinal conditions
Fuhrmann G, Leroux J (2010)
J Control Release 148 (1): 37-39DOI: 10.1016/j.jconrel.2010.07.046
Prevention measures and exploratory pharmacological treatments of celiac disease
Pinier M, Fuhrmann G, Verdu E, Leroux J (2010)
American Journal of Gastroenterology 105 (12): 2551-2561DOI: 10.1038/ajg.2010.372
Tyrosine-based rivastigmine-loaded organogels in the treatment of Alzheimer's disease
Bastiat G, Plourde F, Motulsky A, Furtos A, Dumont Y, Quirion R, Fuhrmann G, Leroux J (2010)
Biomaterials 31 (23): 6031-6038DOI: 10.1016/j.biomaterials.2010.04.009