Jeannine Jung


Jeannine Jung worked until 2010 as a biology laboratory assistant in the pharmaceutical chemistry department at Saarland University. Her subsequent activities at HIPS deal with the biological testing of newly synthesized substances, e.g. on cell cultures, on different bacterial strains and on enzymes.


Towards the sustainable discovery and development of new antibiotics

Miethke M, Pieroni M, Weber T, Brönstrup M, Hammann P, Halby L, Arimondo P, Glaser P, Aigle B, Bode H, …, Moser H, Müller R (2021)

Nat Rev Chem: 1-24DOI: 10.1038/s41570-021-00313-1

Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners

Frank N, Széles M, Akone S, Rasheed S, Hüttel S, Frewert S, Hamed M, Herrmann J, Schuler S, Hirsch A, Müller R (2021)

Molecules 26 (16)DOI: 10.3390/molecules26164929

Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

Groß S, Panter F, Pogorevc D, Seyfert C, Deckarm S, Bader C, Herrmann J, Müller R (2021)

Chemical ScienceDOI: 10.1039/d1sc02725e

Zebrafish: An Attractive Model to Study Staphylococcus aureus Infection and Its Use as a Drug Discovery Tool

Rasheed S, Fries F, Müller R, Herrmann J (2021)

Pharmaceuticals 14 (6)DOI: 10.3390/ph14060594


Semisynthesis and biological evaluation of amidochelocardin derivatives as broad-spectrum antibiotics

Grandclaudon C, Birudukota N, Elgaher W, Jumde R, Yahiaoui S, Arisetti N, Hennessen F, Hüttel S, Stadler M, Herrmann J, …, Hirsch A, Brönstrup M (2020)

European journal of medicinal chemistry 188DOI: 10.1016/j.ejmech.2019.112005

Synthetic and Biological Studies on New Urea and Triazole Containing Cystobactamid Derivatives

Planke T, Cirnski K, Herrmann J, Müller R, Kirschning A (2020)

Chem. Eur. J. 26 (19): 4289-4296DOI: 10.1002/chem.201904073

The glucocorticoid-induced leucine zipper mediates statin-induced muscle damage

Hoppstädter J, Valbuena Perez J, Linnenberger R, Dahlem C, Legroux T, Hecksteden A, Tse W, Flamini S, Andreas A, Herrmann J, …, Bruscoli S, Kiemer A (2020)

FASEB j. 34 (3): 4684-4701DOI: 10.1096/fj.201902557RRR

Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine

Gampfer T, Wagmann L, Park Y, Cannaert A, Herrmann J, Fischmann S, Westphal F, Müller R, Stove C, Meyer M (2020)

Arch. Toxicol. 94 (6): 2009-2025DOI: 10.1007/s00204-020-02726-1

Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics

Elgaher W, Hamed M, Baumann S, Herrmann J, Siebenbürger L, Krull J, Cirnski K, Kirschning A, Brönstrup M, Müller R, Hartmann R (2020)

Chem. Eur. J. 26 (32): 7219-7225DOI: 10.1002/chem.202000117

Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin

Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukežic T, Bernecker S, Hüttel S, Jansen R, Schmiedel J, Fritzenwanker M, …, Herrmann J, Müller R (2020)

Antibiotics 9 (9)DOI: 10.3390/antibiotics9090619

How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae

Wagmann L, Frankenfeld F, Park Y, Herrmann J, Fischmann S, Westphal F, Müller R, Flockerzi V, Meyer M (2020)

Frontiers in chemistry 8DOI: 10.3389/fchem.2020.00539

The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase

Lilic M, Chen J, Boyaci H, Braffman N, Hubin E, Herrmann J, Müller R, Mooney R, Landick R, Darst S, Campbell E (2020)

Proc. Natl. Acad. Sci. U.S.A.DOI: 10.1073/pnas.2013706117

Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry

Cirnski K, Coetzee J, Herrmann J, Müller R (2020)

J. Vis. Exp. (164)DOI: 10.3791/61703

Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model

Park Y, Meyer M, Müller R, Herrmann J (2020)

Molecules 25 (19)DOI: 10.3390/molecules25194474

PLGA nanocapsules improve the delivery of clarithromycin to kill intracellular Staphylococcus aureus and Mycobacterium abscessus

Anversa Dimer F, Souza Carvalho-Wodarz C, Goes A, Cirnski K, Herrmann J, Schmitt V, Pätzold L, Abed N, Rossi C, Bischoff M, …, Müller R, Lehr C (2020)

Nanomedicine : nanotechnology, biology, and medicine 24DOI: 10.1016/j.nano.2019.102125

Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Ho D, Murgia X, Rossi C, Christmann R, Hüfner de Mello Martins A, Koch M, Andreas A, Herrmann J, Müller R, Empting M, …, Couvreur P, Lehr C (2020)

Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202001407

Protein‐Templated Hit Identification via an Ugi Four‐Component Reaction

Mancini F, Unver M, Elgaher W, Jumde V, Alhayek A, Lukat P, Herrmann J, Witte M, Köck M, Blankenfeldt W, Müller R, Hirsch A (2020)

Chem. Eur. J.DOI: 10.1002/chem.202002250

Synthesis and Biological Evaluation of Novel 2-Substituted ­Analogues of (–)-Pentenomycin I

Zisopoulou S, Bousis S, Haupenthal J, Herrmann J, Müller R, Hirsch A, Komiotis D, Gallos J, Stathakis C (2020)

Synlett 31 (05): 475-481DOI: 10.1055/s-0039-1690772

Discovery of Antibacterial Agents Inhibiting the Energy-Coupling Factor (ECF) Transporters by Structure-Based Virtual Screening

Diamanti E, Setyawati I, Bousis S, mojas l, Swier L, Haupenthal J, Gibson P, Volz C, stanek w, Jaeger m, …, Slotboom D, Hirsch A (2020)

BookDOI: 10.26434/chemrxiv.11728710.v1

Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy

Testolin G, Cirnski K, Rox K, Prochnow H, Fetz V, Grandclaudon C, Mollner T, Baiyoumy A, Ritter A, Leitner C, …, Müller R, Brönstrup M (2020)

Chemical Science 11 (5): 1316-1334DOI: 10.1039/C9SC04769G


Engineering Atypical Tetracycline Formation in Amycolatopsis sulphurea for the Production of Modified Chelocardin Antibiotics

Lukežic T, Fayad A, Bader C, Harmrolfs K, Bartuli J, Groß S, Lešnik U, Hennessen F, Herrmann J, Pikl Š, Petkovic H, Müller R (2019)

ACS Chem. Biol. 14 (3): 468-477DOI: 10.1021/acschembio.8b01125


Starch-Chitosan Polyplexes

Yasar H, Ho D, Rossi C, Herrmann J, Gordon S, Loretz B, Lehr C (2018)

Polymers 10 (3)DOI: 10.3390/polym10030252

Activation of the NLRP3 inflammasome by hyaboron, a new asymmetric boron-containing macrodiolide from the Myxobacterium Hyalangium minutum

Surup F, Chauhan D, Niggemann J, Bartok E, Herrmann J, Koeck M, Zander W, Stadler M, Hornung V, Müller R (2018)

ACS Chem. Biol. 13 (10): 2981-2988DOI: 10.1021/acschembio.8b00659

Octapeptins: lipopeptide antibiotics against multidrug-resistant superbugs

Abou Fayad A, Herrmann J, Müller R (2018)

Cell Chem. Biol. 25 (4): 351-353DOI: 10.1016/j.chembiol.2018.04.003

Biosynthesis of the Klebsiella oxytoca Pathogenicity Factor Tilivalline: Heterologous Expression, in Vitro Biosynthesis, and Inhibitor Development

Tesmar A, Hoffmann M, Abou Fayad A, Hüttel S, Schmitt V, Herrmann J, Müller R (2018)

ACS Chem. Biol. 13 (3): 812-819DOI: 10.1021/acschembio.7b00990


Novel and revisited approaches in antituberculosis drug discovery

Herrmann J, Rybniker J, Müller R (2017)

Curr. Opin. Biotechnol. 48: 94-101DOI: 10.1016/j.copbio.2017.03.023

Thioholgamides: Thioamide-Containing Cytotoxic RiPP Natural Products

Kjaerulff L, Sikandar A, Zaburannyi N, Adam S, Herrmann J, Koehnke J, Müller R (2017)

ACS Chem. Biol. 12 (11): 2837-2841DOI: 10.1021/acschembio.7b00676

Pyxipyrrolones: Structure elucidation and biosynthesis of cytotoxic myxobacterial metabolites

Kjaerulff L, Raju R, Panter F, Scheid U, Garcia R, Herrmann J, Müller R (2017)

Angew. Chem. Int. Ed. 56 (32): 9614-9618DOI: 10.1002/anie.201704790

The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

Fu C, Sikandar A, Donner J, Zaburannyi N, Herrmann J, Reck M, Wagner-Döbler I, Koehnke J, Müller R (2017)

Nat Commun 8 (1)DOI: 10.1038/s41467-017-01671-5

Structure and biosynthesis of crocagins: polycyclic postranslationally modified ribosomal peptides from Chondromyces crocatus

Viehrig K, Surup F, Volz C, Herrmann J, Abou Fayad A, Adam S, Kohnke J, Trauner D, Müller R (2017)

Angew. Chem. (56): 1-5DOI: 10.1002/anie.201612640

Natural products from myxobacteria: novel metabolites and bioactivities

Herrmann J, Fayad A, Müller R (2017)

Nat. Prod. Rep. 34 (2): 135-160DOI: 10.1039/C6NP00106H


Strategies for the discovery and development of new antibiotics from natural products: Three case studies

Herrmann J, Lukezic T, Kling A, Baumann S, Hüttel S, Petkovic H, Müller R (2016)

Contribution: 1-25DOI: 10.1007/82_2016_498

Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies

Maurer C, Fruth M, Empting M, Avrutina O, Hossmann J, Nadmid S, Gorges J, Herrmann J, Kazmaier U, Dersch P, Muller R, Hartmann R (2016)

Future medicinal chemistry 8 (9): 931-47DOI: 10.4155/fmc-2016-0033

Isolation, structure elucidation, and (bio)synthesis of Haprolid, a cell-type-specific myxobacterial cytotoxin

Steinmetz H, Li J, Fu C, Zaburannyi N, Kunze B, Harmrolfs K, Schmitt V, Herrmann J, Reichenbach H, Hofle G, Kalesse M, Müller R (2016)

Angew. Chem. Int. Ed. Engl. 55 (34): 10113-7DOI: 10.1002/anie.201603288

Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency

Tu Q, Yin J, Fu J, Herrmann J, Li Y, Yin Y, Stewart A, Müller R, Zhang Y (2016)

Sci. Rep. 6DOI: 10.1038/srep24648

Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering

Tu Q, Herrmann J, Hu S, Raju R, Bian X, Zhang Y, Müller R (2016)

Sci. Rep. 6DOI: 10.1038/srep21066


Squalenoylation of Chitosan: A Platform for Drug Delivery?

Lepeltier E, Loretz B, Desmaele D, Zapp J, Herrmann J, Couvreur P, Lehr C (2015)

Biomacromolecules 16 (9): 2930-9DOI: 10.1021/acs.biomac.5b00840

Biosynthetic studies of telomycin reveal new lipopeptides with enhanced activity

Fu C, Keller L, Bauer A, Brönstrup M, Froidbise A, Hammann P, Herrmann J, Mondesert G, Kurz M, Schiell M, …, Wink J, Müller R (2015)

J. Am. Chem. Soc. 137 (24): 7692-7705DOI: 10.1021/jacs.5b01794

Targeting DnaN for tuberculosis therapy using novel griselimycins

Kling A, Lukat P, Almeida D, Bauer A, Fontaine E, Sordello S, Zaburannyi N, Herrmann J, Wenzel S, König C, …, Lagrange S, Müller R (2015)

Science 348 (6239): 1106-1112DOI: 10.1126/science.aaa4690

Synthesis and biological evaluation of cystobactamid 507: a bacterial topoisomerase inhibitor from Cystobacter sp

Moreno M, Elgaher W, Herrmann J, Schläger N, Hamed M, Baumann S, Müller R, Hartmann R, Kirschning A (2015)

Synlett 26 (9): 1175-1178DOI: 10.1055/s-0034-1380509

Cystodienoic acid: A new diterpene isolated from the myxobacterium Cystobacter sp.

Raju R, Mohr K, Bernecker S, Herrmann J, Müller R (2015)

J. Antibiot. 68: 473-475DOI: 10.1038/ja.2015.8

Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin

Tang Y, Frewert S, Harmrolfs K, Herrmann J, Karmann L, Kazmaier U, Xia L, Zhang Y, Müller R (2015)

J. Biotechnol. 194: 112-114DOI: 10.1016/j.jbiotec.2014.12.008


Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity

Baumann S, Herrmann J, Raju R, Steinmetz H, Mohr K, Hüttel S, Harmrolfs K, Stadler M, Müller R (2014)

Angew. Chem. Int. Ed. 53 (52): 14605-14609DOI: 10.1002/anie.201409964

Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant staphylococci

Surup F, Viehrig K, Mohr K, Herrmann J, Jansen R, Müller R (2014)

Angew. Chem. Int. Ed. Engl. 49 (53): 13588-13591DOI: 10.1002/anie.201406973

Cystobactamid und Derivate als Antibiotika

Baumann S, Herrmann J, Mohr K, Steinmetz H, Gerth K, Raju R, Müller R (2014)

Patent (1451)


Discovery and biological activity of new chondramides from Chondromyces sp.

Herrmann J, Hüttel S, Müller R (2013)

ChemBioChem 14 (13): 1573-1580DOI: 10.1002/cbic.201300140

Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues

Li X, Herrmann J, Zang Y, Grellier P, Prado S, Müller R, Nay B (2013)

Beilstein J. Org. Chem. 9: 1551-1558DOI: 10.3762/bjoc.9.176

In vivo evidence for a prodrug activation mechanism during colibactin maturation

Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart A, Zhang Y, Müller R (2013)

ChemBioChem 14 (10): 1194-1197DOI: 10.1002/cbic.201300208

Activity-guided screening of bioactive natural compounds implementing a new glucocorticoid-receptor-translocation assay and detection of new anti-inflammatory steroids from bacteria

Kaufmann K, Simmons L, Herrmann J, Schwär G, Luniak N, Müller R (2013)

Biotechnol. Lett. 35 (1): 11-20DOI: 10.1007/s10529-012-1042-0


The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles

Ruge C, Schaefer U, Herrmann J, Kirch J, Cañadas O, Echaide M, Pérez-Gil J, Casals C, Müller R, Lehr C (2012)

PLoS ONE 7 (7)DOI: 10.1371/journal.pone.0040775

Rubimycinone A, a new anthraquinone from a terrestrial Streptomyces sp.

Raju R, Gromyko O, Fedorenko V, Herrmann J, Luzhetskyy A, Müller R (2012)

Tetrahedron Lett. 54 (8): 900-902DOI: 10.1016/j.tetlet.2012.11.130

Pretubulysin: From hypothetical biosynthetic intermediate to potential lead in tumor therapy

Herrmann J, Elnakady Y, Wiedmann R, Ullrich A, Rohde M, Kazmaier U, Vollmar A, Müller R (2012)

PLoS ONE 7 (5)DOI: 10.1371/journal.pone.0037416


Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors

Rachid S, Huo L, Herrmann J, Stadler M, Köpcke B, Bitzer J, Müller R (2011)

ChemBioChem 12 (6): 922-931DOI: 10.1002/cbic.201100024


Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis

Ullrich A, Chai Y, Pistorius D, Elnakady Y, Herrmann J, Weissman K, Kazmaier U, Müller R (2009)

Angew. Chem. Int. Ed. Engl. 48 (24): 4422-4425DOI: 10.1002/anie.200900406

Synthesis and Biological Evaluation of Pretubulysin and Derivatives

Ullrich A, Herrmann J, Müller R, Kazmaier U (2009)

Eur. J. Org. Chem. 2009 (36): 6367-6378