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Dr Danica Walsh

About

In 2020, Danica obtained her Ph.D. in chemistry from Montana State University (Bozeman MT, United states), where her research focused on the design and synthesis of prodrug antimicrobials to target biofilms.  

Then she moved on as a postdoc at The University of Notre Dame (Notre Dame, IN, United States). Here her work focused on the use of small molecule adjuvants to restore the efficacy of beta-lactam antibiotics towards drug resistant strains of S. aureus

Since September 2022 she is a postdoctoral researcher in the Hirsch lab, studying anti-infective agents targeting multidrug-resistant bacteria. 


2024

Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD

Willocx D, D'Auria L, Walsh D, Scherer H, Alhayek A, Hamed M, Borel F, Diamanti E, Hirsch A (2024)

Angew. Chem., Int. Ed. Engl.DOI: 10.1002/anie.202414615

IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding

Hamid R, Walsh D, Diamanti E, Aguilar D, Lacour A, Hamed M, Hirsch A (2024)

Structure (London, England : 1993) 32 (12): 2390-2398DOI: 10.1016/j.str.2024.10.009

2023

New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development

Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)

J. Med. Chem.DOI: 10.1021/acs.jmedchem.3c01660

New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development

Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)

BookDOI: 10.26434/chemrxiv-2023-24tmj