Dr Danica Walsh
About
In 2020, Danica obtained her Ph.D. in chemistry from Montana State University (Bozeman MT, United states), where her research focused on the design and synthesis of prodrug antimicrobials to target biofilms.
Then she moved on as a postdoc at The University of Notre Dame (Notre Dame, IN, United States). Here her work focused on the use of small molecule adjuvants to restore the efficacy of beta-lactam antibiotics towards drug resistant strains of S. aureus.
Since September 2022 she is a postdoctoral researcher in the Hirsch lab, studying anti-infective agents targeting multidrug-resistant bacteria.
2024
Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD
Willocx D, D'Auria L, Walsh D, Scherer H, Alhayek A, Hamed M, Borel F, Diamanti E, Hirsch A (2024)
Angew. Chem., Int. Ed. Engl.DOI: 10.1002/anie.202414615
IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding
Hamid R, Walsh D, Diamanti E, Aguilar D, Lacour A, Hamed M, Hirsch A (2024)
Structure (London, England : 1993) 32 (12): 2390-2398DOI: 10.1016/j.str.2024.10.009
2023
New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development
Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)
J. Med. Chem.DOI: 10.1021/acs.jmedchem.3c01660
New Genetically Engineered Derivatives of Antibacterial Darobac-tins Underpin their Potential for Antibiotic Development
Seyfert C, Müller A, Walsh D, Birkelbach J, Kany A, Porten C, Yuan B, Krug D, Herrmann J, Marlovits T, Hirsch A, Müller R (2023)
BookDOI: 10.26434/chemrxiv-2023-24tmj