Dr Chengzhang Fu


Chengzhang Fu studied biotechnology from 2002 to 2006 at Zhejiang University, China. He received his PhD degree in biochemistry and molecular biology at Institute of Microbiology, Chinese Academy of Sciences in 2011. In 2012, he became Alexander von Humboldt fellow in the group of Professor Rolf Müller at Saarland University, Germany. He continued to work with Professor Müller as a postdoc scientist at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS). In 2019, he joined the “Helmholtz International Labs” programme at HIPS as a junior group leader. His group works on exploring and engineering biosynthetic gene pathways from bacteria and environmental DNA.


Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes

Wang Q, Xie F, Tong Y, Habisch R, Yang B, Zhang L, Müller R, Fu C (2020)

Applied Microbiology and Biotechnology 104 (1): 225-239DOI: 10.1007/s00253-019-10223-4


Armeniaspirol Antibiotic Biosynthesis: Chlorination and Oxidative Dechlorination Steps Affording Spiro4.4non-8-ene

Fu C, Xie F, Hoffmann J, Wang Q, Bauer A, Brönstrup M, Mahmud T, Müller R (2019)

ChemBioChem 20 (6): 764-769DOI: 10.1002/cbic.201800791

Heterologous expression of bacterial natural product biosynthetic pathways

Huo L, Hug J, Fu C, Bian X, Zhang Y, Müller R (2019)

Nat. Prod. Rep. 36: 1412-1436DOI: 10.1039/C8NP00091C


The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD

Fu C, Sikandar A, Donner J, Zaburannyi N, Herrmann J, Reck M, Wagner-Döbler I, Koehnke J, Müller R (2017)

Nat Commun 8 (1)DOI: 10.1038/s41467-017-01671-5

Solving the puzzle of the one-carbon loss in ripostatin biosynthesis

Fu C, Auerbach D, Li Y, Scheid U, Luxenburger E, Garcia R, Irschik H, Müller R (2017)

Angew. Chem. Int. Ed. Engl. 56 (8): 2192-2197DOI: 10.1002/anie.201609950


Isolation, structure elucidation, and (bio)synthesis of Haprolid, a cell-type-specific myxobacterial cytotoxin

Steinmetz H, Li J, Fu C, Zaburannyi N, Kunze B, Harmrolfs K, Schmitt V, Herrmann J, Reichenbach H, Hofle G, Kalesse M, Müller R (2016)

Angew. Chem. Int. Ed. Engl. 55 (34): 10113-7DOI: 10.1002/anie.201603288


Biosynthetic studies of telomycin reveal new lipopeptides with enhanced activity

Fu C, Keller L, Bauer A, Brönstrup M, Froidbise A, Hammann P, Herrmann J, Mondesert G, Kurz M, Schiell M, …, Wink J, Müller R (2015)

J. Am. Chem. Soc. 137 (24): 7692-7705DOI: 10.1021/jacs.5b01794