Genome Mining for Secondary Metabolites

are an invaluable resource for developing small-molecule drugs including antibiotics and anti-cancer drugs. A large percentage of approved drugs are related to natural products. Microorganisms not only [...] to the fact that antibiotic…

Drug Design and Optimisation

adopt a target-based strategy focused on a diverse portfolio of biologically relevant, underexplored drug targets, including enzymes, transporters, and regulators within bacterial pathogens. These targets [...] microbiota. We employ a range…

Antimicrobials through Chemoenzymatic Synthesis

historically played a crucial role in drug discovery due to their bioactivity-rich scaffolds, which serve as valuable templates for therapeutic agents. However, their use in drug development has dwindled, primarily

Natural products from underexplored pathways and extreme environments

Natural products exhibit versatile bioactivities and provide valuable lead structures for drug discovery. Although the total number of characterized natural products increased over the last decades, only [...] required for the development…

Natural Product Biotechnology

interesting enzymes usable in the lab, and applying them for efficient biocatalytic or chemo-enzymatic drug synthesis. Overall, our research not only enables efficient exploration of natural products, but also