Genome Mining for Secondary Metabolites

, and economic development. In addition to the fact that antibiotic misuse causes the emergence of drug-resistant microorganisms, the scarce amount of new antibiotic classes in the drug development pipeline [...] is urgently needed.…

Drug Design and Optimisation

adopt a target-based strategy focused on a diverse portfolio of biologically relevant, underexplored drug targets, including enzymes, transporters, and regulators within bacterial pathogens. These targets [...] microbiota. We employ a range…

Antimicrobials through Chemoenzymatic Synthesis

Natural products (NPs) have historically played a crucial role in drug discovery due to their bioactivity-rich scaffolds, which serve as valuable templates for therapeutic agents. However, their use in drug development has dwindled,…

Natural products from underexplored pathways and extreme environments

Natural products exhibit versatile bioactivities and provide valuable lead structures for drug discovery. Although the total number of characterized natural products increased over the last [...] required for the development of…

Natural Product Biotechnology

interesting enzymes usable in the lab, and applying them for efficient biocatalytic or chemo-enzymatic drug synthesis. Overall, our research not only enables efficient exploration of natural products, but