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Researchers in HIPS Laboratory

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Searched for "drug". Displaying results 71 to 80 of 718.

Consistent Prediction of Mutation Effect on Drug Binding in HIV-1 Protease Using Alchemical Calculations

Publication
Bastys T, Gapsys V, Doncheva N, Kaiser R, Groot B, Kalinina O (2018)
Journal of chemical theory and computation, 14, 7, 3397-3408, 10.1021/acs.jctc.7b01109, 29847122

Expression and characterization of pantothenate energy-coupling factor transporters as an anti-infective drug target

Publication
Shams A, Bousis S, Diamanti E, Elgaher W, Zeimetz L, Haupenthal J, Slotboom D, Hirsch A (2024)
Protein Sci., 33, 11, 10.1002/pro.5195, 39473025

Simulated tempering-enhanced umbrella sampling improves convergence of free energy calculations of drug membrane permeation

Publication
Sousa C, Becker R, Lehr C, Kalinina O, Hub J (2022)
bioRxiv, 10.1101/2022.11.13.516136

Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization

Publication
Fittler H, Avrutina O, Glotzbach B, Empting M, Kolmar H (2013)
Org. Biomol. Chem., 11, 11, 1848-57, 10.1039/c3ob27469a, 23361403

Pulmonary drug delivery: from generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges

Publication
Ruge C, Kirch J, Lehr C (2013)
The Lancet. Respiratory medicine, 1, 5, 402-413, 10.1016/S2213-2600(13)70072-9, 24429205

Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis

Publication
Salomon J, Galeron P, Schulte N, Morow P, Severynse-Stevens D, Huwer H, Daum N, Lehr C, Hickey A, Ehrhardt C (2013)
Therapeutic delivery, 4, 8, 915-923, 10.4155/tde.13.62

Influence of the application area on finite dose permeation in relation to drug type applied

Publication
Hahn T, Selzer D, Neumann D, Kostka K, Lehr C, Schaefer U (2012)
Experimental Dermatology, 21, 3, 233-235, 10.1111/j.1600-0625.2011.01424.x

Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo

Publication
Linn M, Collnot E, Djuric D, Hempel K, Fabian E, Kolter K, Lehr C (2012)
European Journal of Pharmaceutical Sciences, 45, 3, 336-343, 10.1016/j.ejps.2011.11.025

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products

Publication
Hittinger M, Schneider-Daum N, Lehr C (2017)
European Journal of Pharmaceutics and Biopharmaceutics, 118, 73-78, 10.1016/j.ejpb.2017.02.019

The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery

Publication
Sommer R, Wagner S, Varrot A, Nycholat C, Khaledi A, Häussler S, Paulson J, Imberty A, Titz A (2016)
Chem Sci, 7, 8, 4990-5001, 10.1039/c6sc00696e, 30155149