
Dr Felix Deschner
About
Felix studied Applied Biology at the Bonn-Rhein-Sieg University of Applied Sciences and finished his double degree in corporation with the Robert Gordon University in Scotland where he completed the Honours Program in Bioscience and Biomedical Science. For his performance, he was awarded the Top Biological Science Student Award from the Royal Society of Biology. As a postgraduate, he followed up his studies in Molecular Biology at the Saarland University where he worked in the group of Prof. Rolf Müller. He established an in vivo infection model using zebrafish larvae, which can be applied at early stages of the drug discovery process.
In 2024, he successfully completed his PhD thesis in the department of Microbial Natural Products where he focused on mode-of-action studies of Chlorotonils as well as their ADMET profiling. Additionally, he is involved in the activity-guided identification of novel antibacterial natural products and the elucidation of structure-activity relationships.
2024
Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application
Hofer W, Deschner F, Jézéquel G, Pessanha de Carvalho L, Abdel-Wadood N, Pätzold L, Bernecker S, Morgenstern B, Kany A, Große M, …, Herrmann J, Müller R (2024)
Angewandte Chemie (International ed. in English) 63 (19)DOI: 10.1002/anie.202319765
Point mutations in the ygiV promoter region lead to cystobactamid resistance and reduced virulence in E. coli
Müller R, Risch T, Kolling D, Mostert D, Seedorf T, Heimann D, Kohnhäuser D, Deschner F, Fries F, Solga D, …, Herrmann J, Sieber S (2024)
BookDOI: 10.21203/rs.3.rs-3751821/v1
Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli
Deschner F, Risch T, Baier C, Schlüter D, Herrmann J, Müller R (2024)
Microbiology Spectrum 12 (1)DOI: 10.1128/spectrum.03079-23
2023
The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection
Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker T, Neumann-Schaal M, Paul L, Nübel U, …, Fuchs T, Strowig T (2023)
Cell Host MicrobeDOI: 10.1016/j.chom.2023.04.003
2022
Darobactins Exhibiting Superior Antibiotic Activity by Cryo-EM Structure Guided Biosynthetic Engineering
Seyfert C, Porten C, Yuan B, Deckarm S, Panter F, Bader C, Coetzee J, Deschner F, Tehrani K, Higgins P, …, Herrmann J, Müller R (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202214094
Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives
Müller R, Hofer W, Oueis E, Abou Fayad A, Deschner F, Andreas A, Carvalho L, Hüttel S, Bernecker S, Pätzold L, …, Held J, Herrmann J (2022)
Angewandte Chemie (International ed. in English)DOI: 10.1002/anie.202202816