Dr Joachim Hug
About
Joachim Hug received his Bachelor of Science in “Pharmaceutical Science” in 2012 and his Diplom-Pharmacy degree in 2015 for his diploma thesis “Enzymatic logic in biosynthesis of benzoxazole antibiotics” carried out at the University of Cambridge in Prof. Peter Leadlay’s laboratory, from the University of Freiburg. In 2016, he became a registered pharmacist and he started as a PhD student at HIPS in the department Microbial Natural Products under the supervision of Prof. Dr. Rolf Müller. At the same time, he started his postgraduate specialisation in Pharmaceutical Analysis and in 2017, he received a scholarship from the Boehringer Ingelheim Fonds. His research focuses on the biosynthesis of microbial natural products from myxobacteria with an emphasis on downregulated biosynthetic pathways.
2022
New Deoxyenhygrolides from Plesiocystis pacifica Provide Insights into Butenolide Core Biosynthesis
Hug J, Kjaerulff L, Garcia R, Müller R (2022)
Marine drugs 20 (1)DOI: 10.3390/md20010072
2021
Genome-Guided Discovery of the First Myxobacterial Biarylitide Myxarylin Reveals Distinct C-N Biaryl Crosslinking in RiPP Biosynthesis
Hug J, Frank N, Walt C, Šenica P, Panter F, Müller R (2021)
Molecules 26 (24)DOI: 10.3390/molecules26247483
Structure and Biosynthesis of Myxofacyclines: Unique Myxobacterial Polyketides Featuring Varing and Rare Heterocycles *
Popoff A, Hug J, Walesch S, Garcia R, Keller L, Müller R (2021)
Chem. Eur. J. 27 (67): 16654-16661DOI: 10.1002/chem.202103095
Structure and biosynthesis of sorangipyranone - a new γ-dihydropyrone from the myxobacterial strain MSr12020
Okoth D, Hug J, Mándi A, Kurtán T, Garcia R, Müller R (2021)
Journal of Industrial Microbiology & Biotechnology 48 (3-4)DOI: 10.1093/jimb/kuab029
2020
2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside
Okoth D, Hug J, Garcia R, Spröer C, Overmann J, Müller R (2020)
Molecules (Basel, Switzerland) 25 (11)DOI: 10.3390/molecules25112676
Biosynthesis of Cittilins, Unusual Ribosomally Synthesized and Post-translationally Modified Peptides from Myxococcus xanthus
Hug J, Dastbaz J, Adam S, Revermann O, Koehnke J, Krug D, Müller R (2020)
ACS chemical biology 15 (8): 2221-2231DOI: 10.1021/acschembio.0c00430
Bacteria as genetically programmable producers of bioactive natural products
Hug J, Krug D, Müller R (2020)
Nat. rev. chem. 4 (4): 172-193DOI: 10.1038/s41570-020-0176-1
Host Development for Heterologous Expression and Biosynthetic Studies of Myxobacterial Natural Products
Hug J, Müller R (2020)
In press: 149-216DOI: 10.1016/B978-0-12-409547-2.14818-8
2019
Heterologous expression of bacterial natural product biosynthetic pathways
Huo L, Hug J, Fu C, Bian X, Zhang Y, Müller R (2019)
Nat. Prod. Rep. 36: 1412-1436DOI: 10.1039/C8NP00091C
Genome mining reveals uncommon alkylpyrones as type III PKS products from myxobacteria
Hug J, Panter F, Krug D, Müller R (2019)
J. Ind. Microbiol. Biotechnol. 46 (3-4): 319-334DOI: 10.1007/s10295-018-2105-6
2018
Concepts and Methods to Access Novel Antibiotics from Actinomycetes
Hug J, Bader C, Remškar M, Cirnski K, Müller R (2018)
Antibiotics 7 (2)DOI: 10.3390/antibiotics7020044