EN | DE

Dr Ahmed S. Abdelsamie

About

Dr. Ahmed S. Abdelsamie is a postdoctoral researcher at the Helmholtz institute for Pharmaceutical Research Saarland (HIPS) in the department of Drug Design and Optimization (DDOP). Dr. Abdelsamie works in the field of medicinal chemistry with focus in the design and optimization of novel antiinfective and antivirulence agents. Additionally, he is contributing to the design, the synthesis and the biological evaluation of inhibitors of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenases (17β-HSDs) in collaboration with Pharmaceutical and Medicinal Chemistry department, Faculty of Pharmacy, Saarland University. Dr. Abdelsamie received his B.Sc. and his Master degree in medicinal chemistry from Ain Shams University, Cairo, Egypt. In 2013, he received his PhD in medicinal chemistry from Saarland University.


2021

Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor

Khairat S, Omar M, Ragab F, Roy S, Turab Naqvi A, Abdelsamie A, Hirsch A, Galal S, Hassan M, El Diwani H (2021)

Archiv der Pharmazie 354 (9)DOI: 10.1002/ardp.202100080

A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Schütz C, Ho D, Hamed M, Abdelsamie A, Röhrig T, Herr C, Kany A, Rox K, Schmelz S, Siebenbürger L, …, Lehr C, Empting M (2021)

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12)DOI: 10.1002/advs.202004369

2015

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

Abdelsamie A, Bey E, Gargano E, van Koppen C, Empting M, Frotscher M (2015)

European journal of medicinal chemistry 103: 56-68DOI: 10.1016/j.ejmech.2015.08.030

2014

Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker

Abdelsamie A, Bey E, Hanke N, Empting M, Hartmann R, Frotscher M (2014)

European journal of medicinal chemistry 82: 394-406DOI: 10.1016/j.ejmech.2014.05.074