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Dirk Hauck

About

Dirk Hauck made an apprenticeship as Chemielaborant at Merck in Darmstadt and received a Vordiplom in Chemistry from the University of Frankfurt. Since February 2011 he is in the Titz group as lab technician. 
He is mainly involved in chemical synthesis and analysis, support of lab members, and organizes the lab routine and maintenance of the equipment.


2020

Directing Drugs to Bugs: Antibiotic-Carbohydrate Conjugates Targeting Biofilm-Associated Lectins of Pseudomonas aeruginosa

Meiers J, Zahorska E, Röhrig T, Hauck D, Wagner S, Titz A (2020)

Journal of medicinal chemistry 63 (20): 11707-11724DOI: 10.1021/acs.jmedchem.0c00856

2019

Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors

Sommer R, Rox K, Wagner S, Hauck D, Henrikus S, Newsad S, Arnold T, Ryckmans T, Brönstrup M, Imberty A, …, Hartmann R, Titz A (2019)

Journal of medicinal chemistry 62 (20): 9201-9216DOI: 10.1021/acs.jmedchem.9b01120

2018

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa

Sommer R, Wagner S, Rox K, Varrot A, Hauck D, Wamhoff E, Schreiber J, Ryckmans T, Brunner T, Rademacher C, …, Imberty A, Titz A (2018)

Journal of the American Chemical Society 140 (7): 2537-2545DOI: 10.1021/jacs.7b11133

2017

Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging

Wagner S, Hauck D, Hoffmann M, Sommer R, Joachim I, Müller R, Imberty A, Varrot A, Titz A (2017)

Angewandte Chemie (International ed. in English) 56 (52): 16559-16564DOI: 10.1002/anie.201709368

Photorhabdus luminescens lectin A (PllA): A new probe for detecting α-galactoside-terminating glycoconjugates

Beshr G, Sikandar A, Jemiller E, Klymiuk N, Hauck D, Wagner S, Wolf E, Koehnke J, Titz A (2017)

J Biol Chem 292 (48): 19935-19951DOI: 10.1074/jbc.M117.812792

Efficient Two Step β-Glycoside Synthesis from N-Acetyl d-Glucosamine: Scope and Limitations of Copper(II) Triflate-Catalyzed Glycosylation

Sommer R, Hauck D, Titz A (2017)

ChemistrySelect 2 (15)DOI: 10.1002/slct.201700161

2016

O-Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2-O-methyl-L-selenofucopyranoside

Sommer R, Hauck D, Varrot A, Imberty A, Künzler M, Titz A (2016)

Beilstein journal of organic chemistry 12: 2828-2833DOI: 10.3762/bjoc.12.282

Development of a competitive binding assay for the Burkholderia cenocepacia lectin BC2L-A and structure activity relationship of natural and synthetic inhibitors

Beshr G, Sommer R, Hauck D, Siebert D, Hofmann A, Imberty A, Titz A (2016)

Med Chem Commun 7 (3): 519-530DOI: 10.1039/C5MD00557D

Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa

Joachim I, Rikker S, Hauck D, Ponader D, Boden S, Sommer R, Hartmann L, Titz A (2016)

Org. Biomol. Chem. 14 (33): 7933-48DOI: 10.1039/c6ob01313a

2015

Cinnamide Derivatives of d-Mannose as Inhibitors of the Bacterial Virulence Factor LecB from Pseudomonas aeruginosa

Sommer R, Hauck D, Varrot A, Wagner S, Audfray A, Prestel A, Möller H, Imberty A, Titz A (2015)

ChemistryOpen 4 (6): 756-67DOI: 10.1002/open.201500162

Synthesis of mannoheptose derivatives and their evaluation as inhibitors of the lectin LecB from the opportunistic pathogen Pseudomonas aeruginosa

Hofmann A, Sommer R, Hauck D, Stifel J, Göttker-Schnetmann I, Titz A (2015)

Carbohydrate research 412: 34-42DOI: 10.1016/j.carres.2015.04.010

2014

Methylated glycans as conserved targets of animal and fungal innate defense

Wohlschlager T, Butschi A, Grassi P, Sutov G, Gauss R, Hauck D, Schmieder S, Knobel M, Titz A, Dell A, …, Aebi M, Künzler M (2014)

Proceedings of the National Academy of Sciences of the United States of America 111 (27): 2787-96DOI: 10.1073/pnas.1401176111

2013

Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes

Hauck D, Joachim I, Frommeyer B, Varrot A, Philipp B, Möller H, Imberty A, Exner T, Titz A (2013)

ACS chemical biology 8 (8): 1775-84DOI: 10.1021/cb400371r