Researcher in Laboratory © HIPS

Christine Walt


Christine Walt studied chemistry at the University of Saarland and obtained her bachelor’s degree in 2016 for her research on the HPLC-MS-based investigation of in vitro metabolic stability of anti-infectives against Pseudomonas aeruginosa at the HIPS, under supervision of Prof. Rolf Hartmann. She proceeded with her studies in chemistry, concluding with the preparation of her master thesis in 2018 with Prof. Hartmann as well. Herein, she focused on analytical techniques like fluorescence polarization (FP), saturation transfer difference (STD) NMR and microscale thermophoresis (MST) for evaluation of the binding and activity of predefined hit compounds against nucleic-acid binding target proteins, like CsrA and LANA. Her strong interest in analytical chemistry of natural products finally led Christine to Prof. Rolf Müllers group at the HIPS, where she started her PhD in 2018. Her work is dedicated to the isolation and structure elucidation of novel secondary metabolites from myxobacteria following a metabolomics-based statistical approach to access chemically new natural products as well as the classical bioactivity-guided approach for identification of secondary metabolites especially targeting Mycobacterium tuberculosis.


Total synthesis of Myxoprincomide, a secondary metabolite from Myxococcus xanthus

Kohr M, Walt C, Dastbaz J, Müller R, Kazmaier U (2022)

Org. Biomol. Chem.DOI: 10.1039/d2ob02021a

Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium

Bader C, Panter F, Garcia R, Tchesnokov E, Haid S, Walt C, Spröer C, Kiefer A, Götte M, Overmann J, Pietschmann T, Müller R (2022)

Chem. Eur. J. 28 (10)DOI: 10.1002/chem.202104484


Genome-Guided Discovery of the First Myxobacterial Biarylitide Myxarylin Reveals Distinct C-N Biaryl Crosslinking in RiPP Biosynthesis

Hug J, Frank N, Walt C, Šenica P, Panter F, Müller R (2021)

Molecules 26 (24)DOI: 10.3390/molecules26247483


Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus

Kirsch P, Jakob V, Elgaher W, Walt C, Oberhausen K, Schulz T, Empting M (2020)

ACS chemical biology 15 (2): 388-395DOI: 10.1021/acschembio.9b00845