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Dr Alwin Hartman

About

-    Public relations at HIPS: co-responsible for the content of the HIPS website and social media
-    Contact person for internal and public events 


2020

Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry

Hartman A, Elgaher W, Hertrich N, Andrei S, Ottmann C, Hirsch A (2020)

ACS medicinal chemistry letters 11 (5): 1041-1046DOI: 10.1021/acsmedchemlett.9b00541

Flotillin-mediated membrane fluidity controls peptidoglycan synthesis and MreB movement

Zielinska A, Savietto A, Sousa Borges A, Martinez D, Berbon M, Roelofsen J, Hartman A, Boer R, van der Klei I, Hirsch A, …, Bramkamp M, Scheffers D (2020)

eLife 9DOI: 10.7554/eLife.57179

Potential Dental Biofilm Inhibitors: Dynamic Combinatorial Chemistry Affords Sugar-Based Molecules that Target Bacterial Glucosyltransferase

Hartman A, Jumde V, Elgaher W, Te Poele E, Dijkhuizen L, Hirsch A (2020)

ChemMedChemDOI: 10.1002/cmdc.202000222

2019

Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol

Hartman A, Gierse R, Hirsch A (2019)

European journal of organic chemistry 2019 (22): 3581-3590DOI: 10.1002/ejoc.201900327

Concepts and Core Principles of Fragment-Based Drug Design

Kirsch P, Hartman A, Hirsch A, Empting M (2019)

Molecules (Basel, Switzerland) 24 (23)DOI: 10.3390/molecules24234309

2018

Lipid-DNAs as Solubilizers of m THPC

Liu Y, de Vries J, Liu Q, Hartman A, Wieland G, Wieczorek S, Börner H, Wiehe A, Buhler E, Stuart M, …, Herrmann A, Hirsch A (2018)

Chem. Eur. J. 24 (4): 798-802DOI: 10.1002/chem.201705206

Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments

Lozinska I, Swierczynska A, Moleda Z, Hartman A, Hirsch A, Czarnocki Z (2018)

Archiv der Pharmazie 351 (11)DOI: 10.1002/ardp.201800194

2017

Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3

Hartman A, Hirsch A (2017)

European journal of medicinal chemistry 136DOI: 10.1016/j.ejmech.2017.04.058

Pentapeptide‐rich peptidoglycan at the Bacillus subtilis cell‐division site

Morales Angeles D, Liu Y, Hartman A, Borisova M, Sousa Borges A, Kok N, Beilharz K, veening j, Mayer C, Hirsch A, Scheffers D (2017)

Molecular microbiology 104 (2): 319-333DOI: 10.1111/mmi.13629

2015

Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

Hartman A, Mondal M, Radeva N, Klebe G, Hirsch A (2015)

International journal of molecular sciences 16 (8): 19184-94DOI: 10.3390/ijms160819184