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Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis
Publikation
Hirsch A,
Alphey M,
Lauw S,
Seet M,
Barandun L,
Eisenreich W,
Rohdich F,
Hunter W,
Bacher A,
Diederich F
(2008)
Organic & biomolecular chemistry, 6, 15, 2719-30, 10.1039/b804375b, 18633530
Organic & biomolecular chemistry, 6, 15, 2719-30, 10.1039/b804375b, 18633530
Synthesis and characterization of cytidine derivatives that inhibit the kinase IspE of the non-mevalonate pathway for isoprenoid biosynthesis
Publikation
Crane C,
Hirsch A,
Alphey M,
Sgraja T,
Lauw S,
Illarionova V,
Rohdich F,
Eisenreich W,
Hunter W,
Bacher A,
Diederich F
(2008)
ChemMedChem, 3, 1, 91-101, 10.1002/cmdc.200700208, 18033714
ChemMedChem, 3, 1, 91-101, 10.1002/cmdc.200700208, 18033714
Phosphate recognition in structural biology
Publikation
Hirsch A,
Fischer F,
Diederich F
(2007)
Angewandte Chemie (International ed. in English), 46, 3, 338-52, 10.1002/anie.200603420, 17154432
Angewandte Chemie (International ed. in English), 46, 3, 338-52, 10.1002/anie.200603420, 17154432
Nonphosphate inhibitors of IspE protein, a kinase in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy
Publikation
Hirsch A,
Lauw S,
Gersbach P,
Schweizer W,
Rohdich F,
Eisenreich W,
Bacher A,
Diederich F
(2007)
ChemMedChem, 2, 6, 806-10, 10.1002/cmdc.200700014, 17361977
ChemMedChem, 2, 6, 806-10, 10.1002/cmdc.200700014, 17361977
Double conjugate addition of dithiols to propargylic carbonyl systems to generate protected 1,3-dicarbonyl compounds
Publikation
Sneddon H,
van den Heuvel A,
Hirsch A,
Booth R,
Shaw D,
Gaunt M,
Ley S
(2006)
The Journal of organic chemistry, 71, 7, 2715-25, 10.1021/jo052514s, 16555825
The Journal of organic chemistry, 71, 7, 2715-25, 10.1021/jo052514s, 16555825
pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA
Publikation
Liu Y,
Ashmawy S,
Latta L,
Weiss A,
Kiefer A,
Nasr S,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2023)
Biomacromolecules, 24, 8, 3742-3754, 10.1021/acs.biomac.3c00424, 37523746
Biomacromolecules, 24, 8, 3742-3754, 10.1021/acs.biomac.3c00424, 37523746
N -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases
Publikation
Konstantinovic J,
Yahiaoui S,
Alhayek A,
Haupenthal J,
Schönauer E,
Andreas A,
Kany A,
Müller R,
Koehnke J,
Berger F,
Bischoff M,
Hartmann R,
Brandstetter H,
Hirsch A
(2020)
J. Med. Chem., 63, 15, 8359-8368, 10.1021/acs.jmedchem.0c00584
J. Med. Chem., 63, 15, 8359-8368, 10.1021/acs.jmedchem.0c00584
Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies
Publikation
Maurer C,
Fruth M,
Empting M,
Avrutina O,
Hossmann J,
Nadmid S,
Gorges J,
Herrmann J,
Kazmaier U,
Dersch P,
Muller R,
Hartmann R
(2016)
Future medicinal chemistry, 8, 9, 931-47, 10.4155/fmc-2016-0033, 27253623
Future medicinal chemistry, 8, 9, 931-47, 10.4155/fmc-2016-0033, 27253623
Crystobactamides
Publikation
Sascha Baumann,
Jennifer Herrmann,
Kathrin Mohr,
Heinrich Steinmetz,
Klaus Gerth,
Ritesh Raju,
Rolf Müller,
Rolf W. Hartmann,
Mostafa Hamed,
Walid A. M. Elgaher,
Maria Moreno,
Franziska Gille,
Liang Liang Wang,
Andreas Kirschning,
Stephan Huettel
(2022)
Patent, C07C237/42; C07C237/44; C07K5/065; C07K7/06; C12N15/52; C12P13/02; A61K38/00, US11225503B2
Patent, C07C237/42; C07C237/44; C07K5/065; C07K7/06; C12N15/52; C12P13/02; A61K38/00, US11225503B2
Novel and Extremely Sensitive NiAl2O4-NiO Nanostructures on an ITO Sensing Electrode for Enhanced Detection of Ascorbic Acid
Publikation
Hammami A,
Bardaoui A,
Eissa S,
Elgaher W,
Chtourou R,
Messaoud O
(2024)
Molecules (Basel, Switzerland), 29, 12, 10.3390/molecules29122837, 38930902
Molecules (Basel, Switzerland), 29, 12, 10.3390/molecules29122837, 38930902