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Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase
Publikation
Palme P,
Grover S,
Abdelaziz R,
Mann L,
Kany A,
Ouologuem L,
Bartel K,
Sonnenkalb L,
Reiling N,
Hirsch A,
Schnappinger D,
Rubinstein J,
Imming P,
Richter A
(2025)
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
J. Med. Chem., 68, 23, 25274-25289, 10.1021/acs.jmedchem.5c02284, 41277442
1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis
Publikation
Gawriljuk V,
Oerlemans R,
Reddem E,
Gierse R,
Hirsch A,
Groves M
(2025)
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
J. Struct. Biol., 217, 3, 10.1016/j.jsb.2025.108236, 40784416
Tobramycin crosslinking improves the colloidal stability of arginine chitosan biodynamers for safe and efficient siRNA delivery
Publikation
Liu Y,
Biesel A,
Kamal M,
Latta L,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2025)
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Int. J. Biol. Macromol., 311, Pt 1, 10.1016/j.ijbiomac.2025.143420, 40274164
Domain adaptable language modeling of chemical compounds identifies potent pathoblockers for Pseudomonas aeruginosa
Publikation
Kallergis G,
Asgari E,
Empting M,
Hirsch A,
Klawonn F,
McHardy A
(2025)
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Commun. Chem., 8, 1, 10.1038/s42004-025-01484-4, 40216964
Analgesic Activity of Novel GABA Esters after Transdermal Delivery
Publikation
Nesterkina M,
Kravchenko I
(2016)
Nat. Prod. Commun., 11, 10, 10.1177/1934578X1601101001
Nat. Prod. Commun., 11, 10, 10.1177/1934578X1601101001
Single-domain antibodies for biomedical applications
Publikation
Krah S,
Schröter C,
Zielonka S,
Empting M,
Valldorf B,
Kolmar H
(2016)
Immunopharmacol. Immunotoxicol., 38, 1, 21-8, 10.3109/08923973.2015.1102934, 26551147
Immunopharmacol. Immunotoxicol., 38, 1, 21-8, 10.3109/08923973.2015.1102934, 26551147
Synthesis and Anticonvulsant Activity of New Calix[4]Arene Derivatives Containing Gamma-Aminobutyric Acid Moieties
Publikation
Nesterkina M,
Alekseeva E,
Kravchenko I
(2016)
Pharm Chem J, 49, 12, 825-829, 10.1007/s11094-016-1380-7
Pharm Chem J, 49, 12, 825-829, 10.1007/s11094-016-1380-7
Proteoid Dynamers with Tunable Properties
Publikation
Liu Y,
Stuart M,
Buhler E,
Lehn J,
Hirsch A
(2016)
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Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme
Publikation
Abdelsamie A,
Bey E,
Gargano E,
van Koppen C,
Empting M,
Frotscher M
(2015)
European journal of medicinal chemistry, 103, 56-68, 10.1016/j.ejmech.2015.08.030, 26322835
European journal of medicinal chemistry, 103, 56-68, 10.1016/j.ejmech.2015.08.030, 26322835
Novel PqsR Inverse Agonists
Publikation
Hamed M
(2015)
Patent, EP 201523196
Patent, EP 201523196