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(1 R ,2 S ,5 R )-5-Methyl-2-(propan-2-yl)cyclohexyl 4-amino-3-phenylbutanoate hydrochloride: Synthesis and anticonvulsant activity
Publikation
Nesterkina M,
Musatov V,
Honcharova O,
Kravchenko I
(2022)
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189
Open Chemistry, 20, 1, 703-707, 10.1515/chem-2022-0189
An Efficient Way to Screen Inhibitors of Energy-Coupling Factor (ECF) Transporters in a Bacterial Uptake Assay
Publikation
Bousis S,
Winkler S,
Haupenthal J,
Fulco F,
Diamanti E,
Hirsch A
(2022)
International journal of molecular sciences, 23, 5, 10.3390/ijms23052637, 35269783
International journal of molecular sciences, 23, 5, 10.3390/ijms23052637, 35269783
First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization
Publikation
Gierse R,
Oerlemans R,
Reddem E,
Gawriljuk V,
Alhayek A,
Baitinger D,
Jakobi H,
Laber B,
Lange G,
Hirsch A,
Groves M
(2022)
Sci. Rep., 12, 1, 10.1038/s41598-022-11205-9, 35508530
Sci. Rep., 12, 1, 10.1038/s41598-022-11205-9, 35508530
Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis
Publikation
Camberlein V,
Fléau C,
Sierocki P,
Li L,
Gealageas R,
Bosc D,
Guillaume V,
Warenghem S,
Leroux F,
Rosell M,
Cheng K,
Medve L,
Prigent M,
Decanter M,
Piveteau C,
Biela A,
Eveque M,
Dumont J,
Mpakali A,
Giastas P,
Herledan A,
Couturier C,
Haupenthal J,
Lesire L,
Hirsch A,
Deprez B,
Stratikos E,
Bouvier M,
Deprez-Poulain R
(2022)
Angew. Chemie, 134, 39, 10.1002/ange.202203560
Angew. Chemie, 134, 39, 10.1002/ange.202203560
Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa
Publikation
Kaya C,
Walter I,
Alhayek A,
Shafiei R,
Jézéquel G,
Andreas A,
Konstantinovic J,
Schönauer E,
Sikandar A,
Haupenthal J,
Müller R,
Brandstetter H,
Hartmann R,
Hirsch A
(2022)
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824
PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE
Publikation
Polish N,
Nesterkina M,
Karkhut A,
Marintsova N,
Zhurakhivska L,
Volianiuk K,
Pokynbroda T,
Kravchenko I,
Karpenko E
(2022)
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956
Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Publikation
Hamid R,
Adam S,
Lacour A,
Gomez L,
Hirsch A
(2022)
bioRxiv, 10.1101/2022.07.04.498669
bioRxiv, 10.1101/2022.07.04.498669
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
Publikation
Chen F,
Elgaher W,
Winterhoff M,
Büssow K,
Waqas F,
Graner E,
Pires-Afonso Y,
Casares Perez L,
La Vega L,
Sahini N,
Czichon L,
Zobl W,
Zillinger T,
Shehata M,
Pleschka S,
Bähre H,
Falk C,
Michelucci A,
Schuchardt S,
Blankenfeldt W,
Hirsch A,
Pessler F
(2022)
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026
Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents
Publikation
Kaya C,
Hirsch A
(2022)
Chimia, 76, 5, 10.2533/chimia.2022.402
Chimia, 76, 5, 10.2533/chimia.2022.402
Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties
Publikation
Kibe A,
Elgaher W,
Rand U,
Zimmer M,
Kany A,
Hermann J,
Müller R,
Cicin-Sain L,
Hirsch A,
Caliskan N
(2022)
SSRN Journal, 10.2139/ssrn.4157446
SSRN Journal, 10.2139/ssrn.4157446