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Gesucht nach "drug". Zeige Ergebnisse 551 bis 560 von 588.

Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor

Publikation
Fittler H, Avrutina O, Empting M, Kolmar H (2014)
Journal of peptide science : an official publication of the European Peptide Society, 20, 6, 415-20, 10.1002/psc.2629, 24723440

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents

Publikation
Masini T, Hirsch A (2014)
Journal of medicinal chemistry, 57, 23, 9740-63, 10.1021/jm5010978, 25210872

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry

Publikation
Mondal M, Radeva N, Köster H, Park A, Potamitis C, Zervou M, Klebe G, Hirsch A (2014)
Angewandte Chemie (International ed. in English), 53, 12, 3259-63, 10.1002/anie.201309682, 24532096

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors

Publikation
Schmitt C, Kail D, Mariano M, Empting M, Weber N, Paul T, Hartmann R, Engel M (2014)
PLoS ONE, 9, 3, 10.1371/journal.pone.0087851, 24676346

A natural-product switch for a dynamic protein interface

Publikation
Scheepstra M, Nieto L, Hirsch A, Fuchs S, Leysen S, Lam C, het Panhuis L, van Boeckel C, Wienk H, Boelens R, Ottmann C, Milroy L, Brunsveld L (2014)
Angewandte Chemie (International ed. in English), 53, 25, 6443-8, 10.1002/anie.201403773, 24821627

Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker

Publikation
Abdelsamie A, Bey E, Hanke N, Empting M, Hartmann R, Frotscher M (2014)
European journal of medicinal chemistry, 82, 394-406, 10.1016/j.ejmech.2014.05.074, 24929290

Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions

Publikation
Hirsch A, Reutenauer P, Le Moignan M, Ulrich S, Boul P, Harrowfield J, Jarowski P, Lehn J (2014)
Chemistry (Weinheim an der Bergstrasse, Germany), 20, 4, 1073-80, 10.1002/chem.201303276, 24339005

PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides

Publikation
Körner M, Sauer G, Heil A, Nasu D, Empting M, Tietze D, Voigt S, Weidler H, Gutmann T, Avrutina O, Kolmar H, Ratajczyk T, Buntkowsky G (2013)
Chemical communications (Cambridge, England), 49, 71, 7839-41, 10.1039/c3cc43978j, 23887355

Total synthesis, stereochemical elucidation and biological evaluation of Ac 2 SGL; a 1,3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis

Publikation
Geerdink D, Horst B, Lepore M, Mori L, Puzo G, Hirsch A, Gilleron M, Libero G, Minnaard A (2013)
, 10.1039/C2SC21620E

Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site

Publikation
Mombelli P, Le Chapelain C, Munzinger N, Joliat E, Illarionov B, Schweizer W, Hirsch A, Fischer M, Bacher A, Diederich F (2013)
, 10.1002/EJOC.201201467