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Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening
Publikation
Di Zhu,
Johannsen S,
Masini T,
Simonin C,
Haupenthal J,
Illarionov B,
Andreas A,
Awale M,
Gierse R,
van der Laan T,
van der Vlag R,
Nasti R,
Poizat M,
Buhler E,
Reiling N,
Müller R,
Fischer M,
Reymond J,
Hirsch A
(2022)
Chem. Sci., 13, 36, 10686-10698, 10.1039/D2SC02371G, 36320685
Chem. Sci., 13, 36, 10686-10698, 10.1039/D2SC02371G, 36320685
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships
Publikation
Steele A,
Kiefer A,
Hwang D,
Yang D,
Teijaro C,
Adhikari A,
Rader C,
Shen B
(2023)
Journal of medicinal chemistry, 66, 2, 1562-1573, 10.1021/acs.jmedchem.2c01771, 36599039
Journal of medicinal chemistry, 66, 2, 1562-1573, 10.1021/acs.jmedchem.2c01771, 36599039
3D air-liquid interface culture of Cystic Fibrosis bronchial epithelia, macrophages and P. aeruginosa to assess host-pathogen interaction and drug efficacy
Publikation
Montefusco C,
Montefusco-Pereira C
(2020)
Book, 10.22028/D291-31815
Book, 10.22028/D291-31815
Induction of Liver Size Reduction in Zebrafish Larvae by the Emerging Synthetic Cannabinoid 4F-MDMB-BINACA and Its Impact on Drug Metabolism
Publikation
Park Y,
Dahlem C,
Meyer M,
Kiemer A,
Müller R,
Herrmann J
(2022)
Molecules (Basel, Switzerland), 27, 4, 10.3390/molecules27041290, 35209079
Molecules (Basel, Switzerland), 27, 4, 10.3390/molecules27041290, 35209079
Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
Publikation
Park Y,
Meyer M,
Müller R,
Herrmann J
(2023)
International journal of molecular sciences, 24, 12, 10.3390/ijms241210076, 37373226
International journal of molecular sciences, 24, 12, 10.3390/ijms241210076, 37373226
Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro
Publikation
Selo M,
Delmas A,
Springer L,
Zoufal V,
Sake J,
Clerkin C,
Huwer H,
Schneider-Daum N,
Lehr C,
Nickel S,
Langer O,
Ehrhardt C
(2020)
Frontiers in Bioengineering and Biotechnology, 8, 10.3389/fbioe.2020.01030, 33015009
Frontiers in Bioengineering and Biotechnology, 8, 10.3389/fbioe.2020.01030, 33015009
Impact of Drug Administration Routes on the In Vivo Efficacy of the Natural Product Sorangicin a Using a Staphylococcus aureus Infection Model in Zebrafish Embryos
Publikation
Fries F,
Kany A,
Rasheed S,
Hirsch A,
Müller R,
Herrmann J
(2023)
International journal of molecular sciences, 24, 16, 10.3390/ijms241612791
International journal of molecular sciences, 24, 16, 10.3390/ijms241612791
Interaction of nanoparticles with the pulmonary barrier; The role of mucus in health and disease // The Role of Airway Mucus as a Barrier to Nanoparticles: Implications for Pulmonary Drug Delivery
Publikation
Murgia X,
Murgia Esteve X
(2019)
Book, 10.22028/D291-31240
Book, 10.22028/D291-31240
Isolation, structure elucidation and total synthesis of lajollamide A from the marine fungus Asteromyces cruciatus
Publikation
Gulder T,
Hong H,
Correa J,
Egereva E,
Wiese J,
Imhoff J,
Gross H
(2012)
Mar. Drugs, 10, 12, 2912-35, 10.3390/md10122912, 23342379
Mar. Drugs, 10, 12, 2912-35, 10.3390/md10122912, 23342379
Asperentin B, a New Inhibitor of the Protein Tyrosine Phosphatase 1B
Publikation
Wiese J,
Aldemir H,
Schmaljohann R,
Gulder T,
Imhoff J
(2017)
Mar. Drugs, 15, 6, 10.3390/md15060191, 28635658
Mar. Drugs, 15, 6, 10.3390/md15060191, 28635658