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Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis
Publikation
Salomon J,
Galeron P,
Schulte N,
Morow P,
Severynse-Stevens D,
Huwer H,
Daum N,
Lehr C,
Hickey A,
Ehrhardt C
(2013)
Therapeutic delivery, 4, 8, 915-923, 10.4155/tde.13.62
Therapeutic delivery, 4, 8, 915-923, 10.4155/tde.13.62
Pulmonary drug delivery: From generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges
Publikation
Ruge C,
Kirch J,
Lehr C
(2013)
The Lancet Respiratory Medicine, 1, 5, 402-413, 10.1016/S2213-2600(13)70072-9, 24429205
The Lancet Respiratory Medicine, 1, 5, 402-413, 10.1016/S2213-2600(13)70072-9, 24429205
Influence of the application area on finite dose permeation in relation to drug type applied
Publikation
Hahn T,
Selzer D,
Neumann D,
Kostka K,
Lehr C,
Schaefer U
(2012)
Experimental Dermatology, 21, 3, 233-235, 10.1111/j.1600-0625.2011.01424.x
Experimental Dermatology, 21, 3, 233-235, 10.1111/j.1600-0625.2011.01424.x
Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo
Publikation
Linn M,
Collnot E,
Djuric D,
Hempel K,
Fabian E,
Kolter K,
Lehr C
(2012)
European Journal of Pharmaceutical Sciences, 45, 3, 336-343, 10.1016/j.ejps.2011.11.025
European Journal of Pharmaceutical Sciences, 45, 3, 336-343, 10.1016/j.ejps.2011.11.025
Consistent Prediction of Mutation Effect on Drug Binding in HIV-1 Protease Using Alchemical Calculations
Publikation
Bastys T,
Gapsys V,
Doncheva N,
Kaiser R,
Groot B,
Kalinina O
(2018)
Journal of chemical theory and computation, 14, 7, 3397-3408, 10.1021/acs.jctc.7b01109, 29847122
Journal of chemical theory and computation, 14, 7, 3397-3408, 10.1021/acs.jctc.7b01109, 29847122
Fragment Based Drug Discovery by Microscale Thermophoresis Targeting Klebsiella pneumoniae and Escherichia coli IspE
Publikation
Walsh D,
Willocx D,
Hamid R,
Hamed M,
Hirsch A
(2025)
Drug design, development and therapy, 19, 11345-11353, 10.2147/DDDT.S538771, 41439264
Drug design, development and therapy, 19, 11345-11353, 10.2147/DDDT.S538771, 41439264
Tailored phenyl ureas eradicate drug-resistant Mycobacterium tuberculosis by targeting mycolic acid cell wall assembly
Publikation
Mostert D,
Braun J,
Zimmerman M,
Engelhart C,
Berndl S,
Quoika P,
Kany A,
Proietto J,
Penalva-Lopez S,
Wallach J,
Hirsch A,
Zacharias M,
Schnappinger D,
Dartois V,
Sieber S
(2025)
Chem. Sci., 10.1039/d5sc02565f, 40313523
Chem. Sci., 10.1039/d5sc02565f, 40313523
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
Publikation
Formicola B,
Dal Magro R,
Montefusco-Pereira C,
Lehr C,
Koch M,
Russo L,
Grasso G,
Deriu M,
Danani A,
Bourdoulous S,
Re F
(2019)
Journal of nanobiotechnology, 17, 1, 10.1186/s12951-019-0546-3, 31711496
Journal of nanobiotechnology, 17, 1, 10.1186/s12951-019-0546-3, 31711496
A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response
Publikation
Richter C,
Latta L,
Harig D,
Carius P,
Stucki J,
Hobi N,
Hugi A,
Schumacher P,
Krebs T,
Gamrekeli A,
Stöckle F,
Urbschat K,
Montalvo G,
Lautenschläger F,
Loretz B,
Hidalgo A,
Schneider-Daum N,
Lehr C
(2024)
Bioengineering & Transla Med, 10.1002/btm2.10715
Bioengineering & Transla Med, 10.1002/btm2.10715
The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery
Publikation
Sommer R,
Wagner S,
Varrot A,
Nycholat C,
Khaledi A,
Häussler S,
Paulson J,
Imberty A,
Titz A
(2016)
Chem Sci, 7, 8, 4990-5001, 10.1039/c6sc00696e, 30155149
Chem Sci, 7, 8, 4990-5001, 10.1039/c6sc00696e, 30155149