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Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization
Publikation
Fittler H,
Avrutina O,
Glotzbach B,
Empting M,
Kolmar H
(2013)
Org. Biomol. Chem., 11, 11, 1848-57, 10.1039/c3ob27469a, 23361403
Org. Biomol. Chem., 11, 11, 1848-57, 10.1039/c3ob27469a, 23361403
Biopharmaceutical in vitro characterization of CPZEN-45, a drug candidate for inhalation therapy of tuberculosis
Publikation
Salomon J,
Galeron P,
Schulte N,
Morow P,
Severynse-Stevens D,
Huwer H,
Daum N,
Lehr C,
Hickey A,
Ehrhardt C
(2013)
Therapeutic delivery, 4, 8, 915-923, 10.4155/tde.13.62
Therapeutic delivery, 4, 8, 915-923, 10.4155/tde.13.62
Pulmonary drug delivery: From generating aerosols to overcoming biological barriers-therapeutic possibilities and technological challenges
Publikation
Ruge C,
Kirch J,
Lehr C
(2013)
The Lancet Respiratory Medicine, 1, 5, 402-413, 10.1016/S2213-2600(13)70072-9, 24429205
The Lancet Respiratory Medicine, 1, 5, 402-413, 10.1016/S2213-2600(13)70072-9, 24429205
Influence of the application area on finite dose permeation in relation to drug type applied
Publikation
Hahn T,
Selzer D,
Neumann D,
Kostka K,
Lehr C,
Schaefer U
(2012)
Experimental Dermatology, 21, 3, 233-235, 10.1111/j.1600-0625.2011.01424.x
Experimental Dermatology, 21, 3, 233-235, 10.1111/j.1600-0625.2011.01424.x
Soluplus® as an effective absorption enhancer of poorly soluble drugs in vitro and in vivo
Publikation
Linn M,
Collnot E,
Djuric D,
Hempel K,
Fabian E,
Kolter K,
Lehr C
(2012)
European Journal of Pharmaceutical Sciences, 45, 3, 336-343, 10.1016/j.ejps.2011.11.025
European Journal of Pharmaceutical Sciences, 45, 3, 336-343, 10.1016/j.ejps.2011.11.025
A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response
Publikation
Richter C,
Latta L,
Harig D,
Carius P,
Stucki J,
Hobi N,
Hugi A,
Schumacher P,
Krebs T,
Gamrekeli A,
Stöckle F,
Urbschat K,
Montalvo G,
Lautenschläger F,
Loretz B,
Hidalgo A,
Schneider-Daum N,
Lehr C
(2024)
Bioengineering & Transla Med, 10.1002/btm2.10715
Bioengineering & Transla Med, 10.1002/btm2.10715
The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
Publikation
Formicola B,
Dal Magro R,
Montefusco-Pereira C,
Lehr C,
Koch M,
Russo L,
Grasso G,
Deriu M,
Danani A,
Bourdoulous S,
Re F
(2019)
Journal of nanobiotechnology, 17, 1, 10.1186/s12951-019-0546-3, 31711496
Journal of nanobiotechnology, 17, 1, 10.1186/s12951-019-0546-3, 31711496
Cell and tissue-based in vitro models for improving the development of oral inhalation drug products
Publikation
Hittinger M,
Schneider-Daum N,
Lehr C
(2017)
European Journal of Pharmaceutics and Biopharmaceutics, 118, 73-78, 10.1016/j.ejpb.2017.02.019
European Journal of Pharmaceutics and Biopharmaceutics, 118, 73-78, 10.1016/j.ejpb.2017.02.019
The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery
Publikation
Sommer R,
Wagner S,
Varrot A,
Nycholat C,
Khaledi A,
Häussler S,
Paulson J,
Imberty A,
Titz A
(2016)
Chem Sci, 7, 8, 4990-5001, 10.1039/c6sc00696e, 30155149
Chem Sci, 7, 8, 4990-5001, 10.1039/c6sc00696e, 30155149
In situ drug release monitoring with a fiber-optic system: Overcoming matrix interferences using derivative spectrophotometry
Publikation
Guillot A,
Limberge M,
Krämer J,
Lehr C
(2013)
Dissolution Technologies, 20, 2, 15-19
Dissolution Technologies, 20, 2, 15-19