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Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry
Publikation
Bizzarri L,
Steinbrunn D,
Quennesson T,
Lacour A,
Bianchino G,
Bravo P,
Chaignon P,
Lohse J,
Mäser P,
Seemann M,
van Calenbergh S,
Hirsch A,
Hahne H
(2024)
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
ACS Infect. Dis., 10, 12, 4087-4102, 10.1021/acsinfecdis.4c00417, 39566904
Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide
Publikation
Martsynko ?,
Nesterkina M,
Finik ?,
Tsymbaliuk K,
Dyakonenko V,
Shishkina S,
Kravchenko I
(2024)
Molbank, 2024, 2, 10.3390/M1819
Molbank, 2024, 2, 10.3390/M1819
Target repurposing unravels avermectins and derivatives as novel antibiotics inhibiting energy-coupling factor transporters (ECFTs)
Publikation
Haupenthal J,
Rafehi M,
Kany A,
Lespine A,
Stefan K,
Hirsch* A,
Stefan* S
(2024)
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Arch. Pharm., 10.1002/ardp.202400267, 38896404
Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign
Publikation
Johannsen S,
Gierse R,
Olshanova A,
Smerznak E,
Laggner C,
Eschweiler L,
Adeli Z,
Hamid R,
Alhayek A,
Reiling N,
Haupenthal J,
Hirsch A
(2023)
ChemMedChem, 10.1002/cmdc.202200590, 36896721
ChemMedChem, 10.1002/cmdc.202200590, 36896721
Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors
Publikation
Ropponen H,
Diamanti E,
Johannsen S,
Illarionov B,
Hamid R,
Jaki M,
Sass P,
Fischer M,
Haupenthal J,
Hirsch A
(2023)
ChemMedChem, 10.1002/cmdc.202300346, 37718320
ChemMedChem, 10.1002/cmdc.202300346, 37718320
PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides
Publikation
Körner M,
Sauer G,
Heil A,
Nasu D,
Empting M,
Tietze D,
Voigt S,
Weidler H,
Gutmann T,
Avrutina O,
Kolmar H,
Ratajczyk T,
Buntkowsky G
(2013)
Chemical communications (Cambridge, England), 49, 71, 7839-41, 10.1039/c3cc43978j, 23887355
Chemical communications (Cambridge, England), 49, 71, 7839-41, 10.1039/c3cc43978j, 23887355
Total synthesis, stereochemical elucidation and biological evaluation of Ac 2 SGL; a 1,3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis
Publikation
Geerdink D,
Horst B,
Lepore M,
Mori L,
Puzo G,
Hirsch A,
Gilleron M,
Libero G,
Minnaard A
(2013)
, 10.1039/C2SC21620E
, 10.1039/C2SC21620E
Imidazole- and Benzimidazole-Based Inhibitors of the Kinase IspE: Targeting the Substrate-Binding Site and the Triphosphate-Binding Loop of the ATP Site
Publikation
Mombelli P,
Le Chapelain C,
Munzinger N,
Joliat E,
Illarionov B,
Schweizer W,
Hirsch A,
Fischer M,
Bacher A,
Diederich F
(2013)
, 10.1002/EJOC.201201467
, 10.1002/EJOC.201201467
The isoprenoid-precursor dependence of Plasmodium spp
Publikation
van der Meer J,
Hirsch A
(2012)
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Natural product reports, 29, 7, 721-8, 10.1039/c2np20013a, 22555616
Metal-ion-induced shape switching: Stereoselective formation of a dinuclear Hg(II) double helicate from a hydrazonobis(acylhydrazone) ligand
Publikation
Schaeffer G,
Harrowfield J,
Lehn J,
Hirsch A
(2012)
, 10.1016/J.POLY.2012.04.013
, 10.1016/J.POLY.2012.04.013