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Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Publikation
Al-Saad O,
Gabr M,
Darwish S,
Rullo M,
Pisani L,
Miniero D,
Liuzzi G,
Kany A,
Hirsch A,
Abadi A,
Engel M,
Catto M,
Abdel-Halim M
(2024)
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
Publikation
Chen X,
Zhao H,
Wang C,
Hamed M,
Shang Q,
Yang Y,
Diao X,
Sun X,
Hu W,
Jiang X,
Zhang Y,
Hirsch A,
Wu D,
Zhuang J
(2024)
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain
Publikation
Gawriljuk V,
Godoy A,
Oerlemans R,
Welker L,
Hirsch A,
Groves M
(2024)
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329
Nat. Commun., 15, 1, 10.1038/s41467-024-50671-9, 39103329
Fragment Discovery by X-Ray Crystallographic Screening Targeting the CTP Binding Site of Pseudomonas Aeruginosa IspD
Publikation
Willocx D,
D'Auria L,
Walsh D,
Scherer H,
Alhayek A,
Hamed M,
Borel F,
Diamanti E,
Hirsch A
(2024)
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Angew. Chem., Int. Ed. Engl., 10.1002/anie.202414615, 39676054
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE
Publikation
Braun-Cornejo M,
Ornago C,
Sonawane V,
Haupenthal J,
Kany A,
Diamanti E,
Jézéquel G,
Reiling N,
Blankenfeldt W,
Maas P,
Hirsch A
(2024)
ACS omega, 10.1021/acsomega.4c05537
ACS omega, 10.1021/acsomega.4c05537
AI is a viable alternative to high throughput screening: a 318-target study
Publikation
Wallach I,
Hirsch,
Anna K. H. et al.
(2024)
Sci Rep, 14, 1, 10.1038/s41598-024-54655-z, 38565852
Sci Rep, 14, 1, 10.1038/s41598-024-54655-z, 38565852
Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes
Publikation
Geißler A,
Junca H,
Kany A,
Daumann L,
Hirsch A,
Pieper D,
Sieber S
(2024)
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Chem. Sci., 15, 30, 11946-11955, 10.1039/D4SC01940G, 39092115
Spray drying of a zinc complexing agent for inhalation therapy of pulmonary fibrosis
Publikation
Stella J,
Abdelaal M,
Kamal M,
Shehu K,
Alhayek A,
Haupenthal J,
Hirsch A,
Schneider M
(2024)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 202, 10.1016/j.ejps.2024.106891, 39233259
pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA
Publikation
Liu Y,
Ashmawy S,
Latta L,
Weiss A,
Kiefer A,
Nasr S,
Loretz B,
Hirsch A,
Lee S,
Lehr C
(2023)
Biomacromolecules, 24, 8, 3742-3754, 10.1021/acs.biomac.3c00424, 37523746
Biomacromolecules, 24, 8, 3742-3754, 10.1021/acs.biomac.3c00424, 37523746
Discovery of the first small-molecule CsrA-RNA interaction inhibitors using biophysical screening technologies
Publikation
Maurer C,
Fruth M,
Empting M,
Avrutina O,
Hossmann J,
Nadmid S,
Gorges J,
Herrmann J,
Kazmaier U,
Dersch P,
Muller R,
Hartmann R
(2016)
Future medicinal chemistry, 8, 9, 931-47, 10.4155/fmc-2016-0033, 27253623
Future medicinal chemistry, 8, 9, 931-47, 10.4155/fmc-2016-0033, 27253623