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Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
Publikation
Chen F,
Elgaher W,
Winterhoff M,
Büssow K,
Waqas F,
Graner E,
Pires-Afonso Y,
Casares Perez L,
La Vega L,
Sahini N,
Czichon L,
Zobl W,
Zillinger T,
Shehata M,
Pleschka S,
Bähre H,
Falk C,
Michelucci A,
Schuchardt S,
Blankenfeldt W,
Hirsch A,
Pessler F
(2022)
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026
Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents
Publikation
Kaya C,
Hirsch A
(2022)
Chimia, 76, 5, 10.2533/chimia.2022.402
Chimia, 76, 5, 10.2533/chimia.2022.402
Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties
Publikation
Kibe A,
Elgaher W,
Rand U,
Zimmer M,
Kany A,
Hermann J,
Müller R,
Cicin-Sain L,
Hirsch A,
Caliskan N
(2022)
SSRN Journal, 10.2139/ssrn.4157446
SSRN Journal, 10.2139/ssrn.4157446
Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages
Publikation
Sake S,
Kosch C,
Blockus S,
Haid S,
Gunesch A,
Zhang X,
Friesland M,
Trummer S,
Grethe C,
Kühnel A,
Rückert J,
Duprex W,
Huang J,
Rameix-Welti M,
Empting M,
Fischer N,
Hirsch A,
Schulz T,
Pietschmann T
(2022)
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232
Identification of inhibitors targeting the energy-coupling factor (ECF) transporters
Publikation
Diamanti E,
Souza P,
Setyawati I,
Bousis S,
Monjas L,
Swier L,
Shams A,
Tsarenko A,
Stanek W,
Jäger M,
Marrink S,
slotboom d,
Hirsch A
(2024)
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
Communications Biology, 7, 1, 10.1038/s42003-024-05770-0, 38195913
IspE kinase as an anti-infective target: Role of a hydrophobic pocket in inhibitor binding
Publikation
Hamid R,
Walsh D,
Diamanti E,
Aguilar D,
Lacour A,
Hamed M,
Hirsch A
(2024)
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
Structure (London, England : 1993), 32, 12, 2390-2398, 10.1016/j.str.2024.10.009, 39510075
High Target Homology Does Not Guarantee Inhibition: Aminothiazoles Emerge as Inhibitors of Plasmodium falciparum
Publikation
Johannsen S,
Gierse R,
Krüger A,
Edwards R,
Nanna V,
Fontana A,
Di Zhu,
Masini T,
Carvalho L,
Poizat M,
Kieftenbelt B,
Hodge D,
Alvarez S,
Bunt D,
Lacour A,
Shams A,
Meissner K,
Souza E,
Dröge M,
van Vliet B,
Hartog J,
Hutter M,
Held J,
Odom John A,
Wrenger C,
Hirsch* A
(2024)
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
ACS Infect. Dis., 10.1021/acsinfecdis.3c00670, 38367280
Targeting the Plasmodium falciparum IspE Enzyme
Publikation
Diamanti E,
Steinbach A,
Carvalho L,
Ropponen H,
Lacour A,
Hamid R,
Eisa S,
Bravo P,
Bousis S,
Illarionov B,
Fischer M,
Hamed M,
Bach N,
Rottmann M,
Held J,
Witschel M,
Sieber S,
Hirsch A
(2024)
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
ACS omega, 9, 44, 44465-44473, 10.1021/acsomega.4c06038, 39524657
Behavioral and electrophysiological responses of the male medfly, Ceratitis capitata, to thymol and carvacrol ethers
Publikation
Tabanca N,
Cloonan K,
Nesterkina M,
Gill M,
Montgomery W,
Kravchenko I,
Kendra P
(2024)
Pest management science, 10.1002/ps.8324, 39096116
Pest management science, 10.1002/ps.8324, 39096116
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
Publikation
Chan A,
Ho T,
Fathoni I,
Hamid R,
Hirsch A,
Saliba K,
Leeper F
(2024)
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473
RSC Med. Chem., 15, 5, 1773-1781, 10.1039/D4MD00083H, 38784473