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Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?
Publikation
Weidel E,
Negri M,
Empting M,
Hinsberger S,
Hartmann R
(2014)
Future medicinal chemistry, 6, 18, 2057-72, 10.4155/fmc.14.142, 25531968
Future medicinal chemistry, 6, 18, 2057-72, 10.4155/fmc.14.142, 25531968
Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections
Publikation
Hinsberger S,
Jong J,
Groh M,
Haupenthal J,
Hartmann R
(2014)
European journal of medicinal chemistry, 76, 343-51, 10.1016/j.ejmech.2014.02.014, 24589489
European journal of medicinal chemistry, 76, 343-51, 10.1016/j.ejmech.2014.02.014, 24589489
Simultaneous Complexation and Microextraction Using Verbenone Hydrazone as the Ligand with Slotted Quartz Tube-Flame Atomic Absorption Spectrometry (FAAS) for the Sensitive Determination of Copper
Publikation
Özzeybek G,
Borahan T,
Nesterkina M,
Kravchenko I,
Bakirdere S
(2021)
Analytical letters, 54, 14, 2376-2386, 10.1080/00032719.2020.1866594
Analytical letters, 54, 14, 2376-2386, 10.1080/00032719.2020.1866594
Unveiling Adatoms in On-Surface Reactions: Combining Scanning Probe Microscopy with van't Hoff Plots
Publikation
Moreno-López J,
Pérez Paz A,
Gottardi S,
Solianyk L,
Li J,
Monjas L,
Hirsch A,
Mowbray D,
Stöhr M
(2021)
The journal of physical chemistry. C, Nanomaterials and interfaces, 125, 18, 9847-9854, 10.1021/acs.jpcc.1c03134, 34276856
The journal of physical chemistry. C, Nanomaterials and interfaces, 125, 18, 9847-9854, 10.1021/acs.jpcc.1c03134, 34276856
New PqsR Inverse Agonist
Publikation
Schütz C,
Empting M,
Ahmed S,
Hamed M,
Hartmann R,
Röhrig T,
Kany A,
Hirsch A
(2021)
Patent, A61K31/4439; A61K31/506; A61P31/04; C07D401/12; C07D403/12;, WO2021136803A1
Patent, A61K31/4439; A61K31/506; A61P31/04; C07D401/12; C07D403/12;, WO2021136803A1
Quantitative structure–activity relationship study on prolonged anticonvulsant activity of terpene derivatives in pentylenetetrazole test
Publikation
Nesterkina M,
Muratov V,
Ognichenko L,
Kravchenko I,
Kuz’min V
(2021)
Open Chemistry, 19, 1, 1184-1192, 10.1515/chem-2021-0108
Open Chemistry, 19, 1, 1184-1192, 10.1515/chem-2021-0108
Assessment of the rules related to gaining activity against Gram-negative bacteria
Publikation
Ropponen H,
Diamanti E,
Siemens A,
Illarionov B,
Haupenthal J,
Fischer M,
Rottmann M,
Witschel M,
Hirsch A
(2021)
RSC Med. Chem., 10.1039/D0MD00409J
RSC Med. Chem., 10.1039/D0MD00409J
Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes
Publikation
Erdeljac N,
Thiehoff C,
Jumde R,
Daniliuc C,
Höppner S,
Faust A,
Hirsch A,
Gilmour R
(2020)
Journal of medicinal chemistry, 63, 11, 6225-6237, 10.1021/acs.jmedchem.0c00648, 32379447
Journal of medicinal chemistry, 63, 11, 6225-6237, 10.1021/acs.jmedchem.0c00648, 32379447
Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus
Publikation
Kirsch P,
Jakob V,
Elgaher W,
Walt C,
Oberhausen K,
Schulz T,
Empting M
(2020)
ACS chemical biology, 15, 2, 388-395, 10.1021/acschembio.9b00845, 31944659
ACS chemical biology, 15, 2, 388-395, 10.1021/acschembio.9b00845, 31944659
Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry
Publikation
Hartman A,
Elgaher W,
Hertrich N,
Andrei S,
Ottmann C,
Hirsch A
(2020)
ACS medicinal chemistry letters, 11, 5, 1041-1046, 10.1021/acsmedchemlett.9b00541, 32435423
ACS medicinal chemistry letters, 11, 5, 1041-1046, 10.1021/acsmedchemlett.9b00541, 32435423