EN | DE
 info(at)helmholtz-hips.de +49681988063001
 Directions to Google
EN | DE
[Translate to Deutsch:]

Suche

Gesucht nach "drug". Zeige Ergebnisse 561 bis 570 von 680.

First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Publikation
Gierse R, Oerlemans R, Reddem E, Gawriljuk V, Alhayek A, Baitinger D, Jakobi H, Laber B, Lange G, Hirsch A, Groves M (2022)
Sci. Rep., 12, 1, 10.1038/s41598-022-11205-9, 35508530

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Publikation
Camberlein V, Fléau C, Sierocki P, Li L, Gealageas R, Bosc D, Guillaume V, Warenghem S, Leroux F, Rosell M, Cheng K, Medve L, Prigent M, Decanter M, Piveteau C, Biela A, Eveque M, Dumont J, Mpakali A, Giastas P, Herledan A, Couturier C, Haupenthal J, Lesire L, Hirsch A, Deprez B, Stratikos E, Bouvier M, Deprez-Poulain R (2022)
Angew. Chemie, 134, 39, 10.1002/ange.202203560

Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Publikation
Kaya C, Walter I, Alhayek A, Shafiei R, Jézéquel G, Andreas A, Konstantinovic J, Schönauer E, Sikandar A, Haupenthal J, Müller R, Brandstetter H, Hartmann R, Hirsch A (2022)
ACS Infect. Dis., 10.1021/acsinfecdis.1c00628, 35451824

PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE

Publikation
Polish N, Nesterkina M, Karkhut A, Marintsova N, Zhurakhivska L, Volianiuk K, Pokynbroda T, Kravchenko I, Karpenko E (2022)
J microb biotech food sci, 12, 3, 10.55251/jmbfs.5956

Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding

Publikation
Hamid R, Adam S, Lacour A, Gomez L, Hirsch A (2022)
bioRxiv, 10.1101/2022.07.04.498669

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism

Publikation
Chen F, Elgaher W, Winterhoff M, Büssow K, Waqas F, Graner E, Pires-Afonso Y, Casares Perez L, La Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch A, Pessler F (2022)
Nature metabolism, 4, 5, 534-546, 10.1038/s42255-022-00577-x, 35655026

Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents

Publikation
Kaya C, Hirsch A (2022)
Chimia, 76, 5, 10.2533/chimia.2022.402

Screening of Natural Products and Small Molecules Uncovers Novel Coronavirus 1a/1b Frameshifting Inhibitors with Antiviral Properties

Publikation
Kibe A, Elgaher W, Rand U, Zimmer M, Kany A, Hermann J, Müller R, Cicin-Sain L, Hirsch A, Caliskan N (2022)
SSRN Journal, 10.2139/ssrn.4157446

Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages

Publikation
Sake S, Kosch C, Blockus S, Haid S, Gunesch A, Zhang X, Friesland M, Trummer S, Grethe C, Kühnel A, Rückert J, Duprex W, Huang J, Rameix-Welti M, Empting M, Fischer N, Hirsch A, Schulz T, Pietschmann T (2022)
Antimicrobial agents and chemotherapy, 10.1128/aac.01032-22, 36346232

Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

Publikation
Bagnolini G, Balboni B, Schipani F, Gioia D, Veronesi M, Franco F, Kaya C, Jumde R, Ortega J, Girotto S, Hirsch A, Roberti M, Cavalli A (2022)
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685