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Gesucht nach "drug". Zeige Ergebnisse 541 bis 550 von 664.

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

Publikation
Abdelsamie A, Bey E, Gargano E, van Koppen C, Empting M, Frotscher M (2015)
European journal of medicinal chemistry, 103, 56-68, 10.1016/j.ejmech.2015.08.030, 26322835

Novel PqsR Inverse Agonists

Publikation
Hamed M (2015)
Patent, EP 201523196

Fragment growing exploiting dynamic combinatorial chemistry of inhibitors of the aspartic protease endothiapepsin

Publikation
Mondal M, Groothuis D, Hirsch A (2015)
, 10.1039/C5MD00157A

Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS

Publikation
Masini T, Lacy B, Monjas L, Hawksley D, Voogd A, Illarionov B, Iqbal A, Leeper F, Fischer M, Kontoyianni M, Hirsch A (2015)
Organic & biomolecular chemistry, 13, 46, 11263-77, 10.1039/c5ob01666e, 26411373

Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine

Publikation
Swier L, Monjas L, Guskov A, Voogd A, Erkens G, slotboom d, Hirsch A (2015)
ChemBioChem, 16, 5, 819-26, 10.1002/cbic.201402673, 25676607

Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors

Publikation
Huizing A, Mondal M, Hirsch A (2015)
Journal of medicinal chemistry, 58, 13, 5151-63, 10.1021/jm5014133, 25719272

Supramolecular chemistry … and beyond

Publikation
Hirsch A (2015)
Angewandte Chemie (International ed. in English), 54, 38, 11013-4, 10.1002/anie.201506536, 26306880

Engineering a Constrained Peptidic Scaffold towards Potent and Selective Furin Inhibitors

Publikation
Fittler H, Depp A, Avrutina O, Dahms S, Than M, Empting M, Kolmar H (2015)
Chembiochem : a European journal of chemical biology, 16, 17, 2441-4, 10.1002/cbic.201500447, 26426719

Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD

Publikation
Allegretta G, Weidel E, Empting M, Hartmann R (2015)
European journal of medicinal chemistry, 90, 351-9, 10.1016/j.ejmech.2014.11.055, 25437621

Harnessing dynamic combinatorial chemistry in the search for new ligands for protein targets

Publikation
Monjas L, Hirsch A (2015)
Future medicinal chemistry, 7, 16, 2095-8, 10.4155/fmc.15.146, 26510895