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N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa
Publikation
Yahiaoui S,
Voos K,
Haupenthal J,
Wichelhaus T,
Frank D,
Weizel L,
Rotter M,
Brunst S,
Kramer J,
Proschak E,
Ducho C,
Hirsch A
(2021)
RSC Med. Chem., 10.1039/D1MD00187F
RSC Med. Chem., 10.1039/D1MD00187F
Hit-optimization using target-directed dynamic combinatorial chemistry: Development of inhibitors of the anti-infective target 1-deoxy-D-xylulose-5-phosphate synthase
Publikation
Jumde R,
Guadigni M,
Gierse R,
Alhayek A,
Di Zhu,
Hamid Z,
Johannsen S,
Elgaher W,
Neusens P,
Nehls C,
Haupenthal J,
Reiling N,
Hirsch A
(2021)
Chemical Science, 10.1039/D1SC00330E
Chemical Science, 10.1039/D1SC00330E
Citatronic Acid and Derivates thereof for use as a medicament
Publikation
Pessler F.,
Chen F.,
Winterhoff M.,
Büssow K.,
Blankenfeldt W.,
Hirsch A. K. H.,
Elgaher W
(2021)
Patent, WO2022223778, 2022
Patent, WO2022223778, 2022
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis
Publikation
Rosenberger L,
Essen C,
Khutia A,
Kühn C,
Georgi K,
Hirsch A,
Hartmann R,
Badolo L
(2021)
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 164, 10.1016/j.ejps.2021.105884, 34161782
Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies
Publikation
Nesterkina M,
Smola S,
Rusakova N,
Kravchenko I
(2021)
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438
Molecules (Basel, Switzerland), 27, 1, 10.3390/molecules27010206, 35011438
Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization
Publikation
Della Volpe S,
Linciano P,
Listro R,
Tumminelli E,
Amadio M,
Bonomo I,
Elgaher W,
Adam S,
Hirsch A,
Boeckler F,
Vasile F,
Rossi D,
Collina S
(2021)
Bioorganic chemistry, 116, 10.1016/j.bioorg.2021.105305, 34482166
Bioorganic chemistry, 116, 10.1016/j.bioorg.2021.105305, 34482166
Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier
Publikation
Abdallah M,
Hamed M,
Frakolaki E,
Katsamakas S,
Vassilaki N,
Bartenschlager R,
Zoidis G,
Hirsch A,
Abdel-Halim M,
Abadi A
(2021)
European journal of medicinal chemistry, 10.1016/j.ejmech.2021.114034
European journal of medicinal chemistry, 10.1016/j.ejmech.2021.114034
Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class
Publikation
Diamanti E,
Hamed M,
Lacour A,
Bravo P,
Illarionov B,
Fischer M,
Rottmann M,
Witschel M,
Hirsch A
(2021)
ChemMedChem, 10.1002/cmdc.202100679, 34918860
ChemMedChem, 10.1002/cmdc.202100679, 34918860
Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021)
Publikation
Voos K,
Schönauer E,
Alhayek A,
Haupenthal J,
Andreas A,
Müller R,
Hartmann R,
Brandstetter H,
Hirsch A,
Ducho C
(2021)
ChemMedChem, 16, 8, 1198-1198, 10.1002/cmdc.202100229
ChemMedChem, 16, 8, 1198-1198, 10.1002/cmdc.202100229
Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents
Publikation
Nesterkina M,
Barbalat D,
Konovalova I,
Shishkina S,
Atakay M,
Salih B,
Kravchenko I
(2021)
Natural product research, 35, 23, 4978-4987, 10.1080/14786419.2020.1756804, 32336164
Natural product research, 35, 23, 4978-4987, 10.1080/14786419.2020.1756804, 32336164