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Gesucht nach "drug". Zeige Ergebnisse 481 bis 490 von 686.

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors

Publikation
Schmitt C, Kail D, Mariano M, Empting M, Weber N, Paul T, Hartmann R, Engel M (2014)
PLoS ONE, 9, 3, 10.1371/journal.pone.0087851, 24676346

A natural-product switch for a dynamic protein interface

Publikation
Scheepstra M, Nieto L, Hirsch A, Fuchs S, Leysen S, Lam C, het Panhuis L, van Boeckel C, Wienk H, Boelens R, Ottmann C, Milroy L, Brunsveld L (2014)
Angewandte Chemie (International ed. in English), 53, 25, 6443-8, 10.1002/anie.201403773, 24821627

Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker

Publikation
Abdelsamie A, Bey E, Hanke N, Empting M, Hartmann R, Frotscher M (2014)
European journal of medicinal chemistry, 82, 394-406, 10.1016/j.ejmech.2014.05.074, 24929290

Theoretical and structural analysis of long C-C bonds in the adducts of polycyanoethylene and anthracene derivatives and their connection to the reversibility of Diels-Alder reactions

Publikation
Hirsch A, Reutenauer P, Le Moignan M, Ulrich S, Boul P, Harrowfield J, Jarowski P, Lehn J (2014)
Chemistry (Weinheim an der Bergstrasse, Germany), 20, 4, 1073-80, 10.1002/chem.201303276, 24339005

Identification of RAD51-BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry

Publikation
Bagnolini G, Balboni B, Schipani F, Gioia D, Veronesi M, Franco F, Kaya C, Jumde R, Ortega J, Girotto S, Hirsch A, Roberti M, Cavalli A (2022)
ACS Med. Chem. Lett., 13, 8, 1262-1269, 10.1021/acsmedchemlett.2c00063, 35978685

Rheological Properties of Hyaluronic Acid Diluted Solutions as Components of Cosmetics

Publikation
Svetlana Saitarly, Yuriy Pushkarev, Nesterkina M, Serhat Öztürk, Iryna Kravchenko (2021)
Biointerface Res Appl Chem, 12, 2, 1907-1915, 10.33263/BRIAC122.19071915

Identification of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) mutant with improved crystallographic properties

Publikation
Gierse R, Reddem E, Alhayek A, Baitinger D, Hamid Z, Jakobi H, Laber B, Lange G, Hirsch A, Groves (2021)
Biochemical and Biophysical Research Communications, 539, 10.1016/j.bbrc.2020.12.069, 33421767

Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors

Publikation
Kaya C, Walter I, Yahiaoui S, Sikandar A, Alhayek A, Konstantinovic J, Kany A, Haupenthal J, Köhnke J, Hartmann R, Hirsch A (2021)
Angewandte Chemie (International ed. in English), 10.1002/anie.202112295, 34762767

Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design

Publikation
Axer A, Jumde R, Adam S, Faust A, Schäfers M, Fobker M, Koehnke J, Hirsch A, Gilmour R (2021)
Chem. Sci., 12, 4, 1286-1294, 10.1039/D0SC04297H

N-Phenyl-3-Mercaptopropanamide Derivatives as Metallo-Beta-Lactamase Inhibitors for the Treatment of Bacterial Infections

Publikation
Hartmann R, Konstantinovic J, Haupenthal J, Hirsch A, Kany A, Kaya C, Yahiaoui S, Wichelhaus T, Proschak E (2021)
Patent, A61K31/5375; A61P31/04; C07C233/15; C07C233/25; C07C233/33; C07C233/43; C07C233/54; C07C319/02; C07C323/52; C07D295/22;, ‌‌WO2021191219A1