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Gesucht nach "drug". Zeige Ergebnisse 461 bis 470 von 664.

Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?

Publikation
Weidel E, Negri M, Empting M, Hinsberger S, Hartmann R (2014)
Future medicinal chemistry, 6, 18, 2057-72, 10.4155/fmc.14.142, 25531968

Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

Publikation
Hinsberger S, Jong J, Groh M, Haupenthal J, Hartmann R (2014)
European journal of medicinal chemistry, 76, 343-51, 10.1016/j.ejmech.2014.02.014, 24589489

Synthesis, Physicochemical Properties, and Anticonvulsant Activity of the Gaba Complex with a Calix[4]Arene derivative

Publikation
Nesterkina M, Alekseeva E, Kravchenko I (2014)
Pharm Chem J, 48, 2, 82-84, 10.1007/s11094-014-1052-4

Potent inhibitors of human matriptase-1 based on the scaffold of sunflower trypsin inhibitor

Publikation
Fittler H, Avrutina O, Empting M, Kolmar H (2014)
Journal of peptide science : an official publication of the European Peptide Society, 20, 6, 415-20, 10.1002/psc.2629, 24723440

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents

Publikation
Masini T, Hirsch A (2014)
Journal of medicinal chemistry, 57, 23, 9740-63, 10.1021/jm5010978, 25210872

Overcoming the unexpected functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: an in vivo potent antivirulence agent targeting pqs quorum sensing

Publikation
Lu C, Maurer C, Kirsch B, Steinbach A, Hartmann R (2014)
Angewandte Chemie (International ed. in English), 53, 4, 1109-12, 10.1002/anie.201307547, 24338917

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry

Publikation
Mondal M, Radeva N, Köster H, Park A, Potamitis C, Zervou M, Klebe G, Hirsch A (2014)
Angewandte Chemie (International ed. in English), 53, 12, 3259-63, 10.1002/anie.201309682, 24532096

Design and synthesis of a library of lead-like 2,4-bisheterocyclic substituted thiophenes as selective Dyrk/Clk inhibitors

Publikation
Schmitt C, Kail D, Mariano M, Empting M, Weber N, Paul T, Hartmann R, Engel M (2014)
PLoS ONE, 9, 3, 10.1371/journal.pone.0087851, 24676346

A natural-product switch for a dynamic protein interface

Publikation
Scheepstra M, Nieto L, Hirsch A, Fuchs S, Leysen S, Lam C, het Panhuis L, van Boeckel C, Wienk H, Boelens R, Ottmann C, Milroy L, Brunsveld L (2014)
Angewandte Chemie (International ed. in English), 53, 25, 6443-8, 10.1002/anie.201403773, 24821627

Inhibition of 17β-HSD1: SAR of bicyclic substituted hydroxyphenylmethanones and discovery of new potent inhibitors with thioether linker

Publikation
Abdelsamie A, Bey E, Hanke N, Empting M, Hartmann R, Frotscher M (2014)
European journal of medicinal chemistry, 82, 394-406, 10.1016/j.ejmech.2014.05.074, 24929290