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Engineering an Artificial Myxopyronin Derivative with Enhanced Metabolic Stability via Mutasynthesis
Publikation
Kiefer A,
Voltz A,
Scherzer D,
Reberšek R,
Kany A,
Prosser G,
Neuber M,
Reiling N,
Hirsch A,
Müller R
(2025)
, 10.26434/chemrxiv-2025-q4h0n
, 10.26434/chemrxiv-2025-q4h0n
Unlocking the Antiviral Arsenal: Structure-Guided Optimization of Small-Molecule Inhibitors against RSV and hCoV-229E
Publikation
Karhan C,
Sake S,
Gunesch A,
Grethe C,
Hellwinkel B,
Köhler N,
Kiefer A,
Hapko U,
Kany A,
Pietschmann T,
Hirsch A
(2025)
European journal of medicinal chemistry, 10.1016/j.ejmech.2025.117282
European journal of medicinal chemistry, 10.1016/j.ejmech.2025.117282
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d -galactose pentaacetate
Publikation
Zahorska E,
Kuhaudomlarp S,
Minervini S,
Yousaf S,
Lepsik M,
Kinsinger T,
Hirsch A,
Imberty A,
Titz A
(2020)
Chem. Commun., 56, 62, 8822-8825, 10.1039/d0cc03490h
Chem. Commun., 56, 62, 8822-8825, 10.1039/d0cc03490h
Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity
Publikation
Ropponen H,
Bader C,
Diamanti E,
Illarionov B,
Rottmann M,
Fischer M,
Witschel M,
Müller R,
Hirsch A
(2021)
ChemMedChem, 16, 13, 2089-2093, 10.1002/cmdc.202100067, 33844432
ChemMedChem, 16, 13, 2089-2093, 10.1002/cmdc.202100067, 33844432
Dipeptidic Phosphonates: Potent Inhibitors of Pseudomonas aeruginosa Elastase B Showing Efficacy in a Murine Keratitis Model
Publikation
Kiefer A,
Schütz C,
Englisch C,
Kolling D,
Speicher S,
Kany A,
Shafiei R,
Wadood N,
Aljohmani A,
Wirschem N,
Jumde R,
Klein A,
Sikandar A,
Park Y,
Krasteva-Christ G,
Yildiz D,
Abdelsamie A,
Rox K,
Köhnke J,
Müller R,
Bischoff M,
Haupenthal J,
Hirsch A
(2025)
Adv. Sci., 10.1002/advs.202411807, 39973061
Adv. Sci., 10.1002/advs.202411807, 39973061
Synthesis of New Cyclomarin Derivatives and Their Biological Evaluation towards Mycobacterium Tuberculosis and Plasmodium Falciparum
Publikation
Kiefer A,
Bader C,
Held J,
Esser A,
Rybniker J,
Empting M,
Müller R,
Kazmaier U
(2019)
Chem. Eur. J., 25, 37, 8894-8902, 10.1002/chem.201901640, 31012978
Chem. Eur. J., 25, 37, 8894-8902, 10.1002/chem.201901640, 31012978