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New PqsR Inverse Agonist
Publikation
Schütz C,
Empting M,
Ahmed S,
Hamed M,
Hartmann R,
Röhrig T,
Kany A,
Hirsch A
(2021)
Patent, A61K31/4439; A61K31/506; A61P31/04; C07D401/12; C07D403/12;, WO2021136803A1
Patent, A61K31/4439; A61K31/506; A61P31/04; C07D401/12; C07D403/12;, WO2021136803A1
Quantitative structure–activity relationship study on prolonged anticonvulsant activity of terpene derivatives in pentylenetetrazole test
Publikation
Nesterkina M,
Muratov V,
Ognichenko L,
Kravchenko I,
Kuz’min V
(2021)
Open Chemistry, 19, 1, 1184-1192, 10.1515/chem-2021-0108
Open Chemistry, 19, 1, 1184-1192, 10.1515/chem-2021-0108
Assessment of the rules related to gaining activity against Gram-negative bacteria
Publikation
Ropponen H,
Diamanti E,
Siemens A,
Illarionov B,
Haupenthal J,
Fischer M,
Rottmann M,
Witschel M,
Hirsch A
(2021)
RSC Med. Chem., 10.1039/D0MD00409J
RSC Med. Chem., 10.1039/D0MD00409J
Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes
Publikation
Erdeljac N,
Thiehoff C,
Jumde R,
Daniliuc C,
Höppner S,
Faust A,
Hirsch A,
Gilmour R
(2020)
Journal of medicinal chemistry, 63, 11, 6225-6237, 10.1021/acs.jmedchem.0c00648, 32379447
Journal of medicinal chemistry, 63, 11, 6225-6237, 10.1021/acs.jmedchem.0c00648, 32379447
Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi's Sarcoma-Associated Herpesvirus
Publikation
Kirsch P,
Jakob V,
Elgaher W,
Walt C,
Oberhausen K,
Schulz T,
Empting M
(2020)
ACS chemical biology, 15, 2, 388-395, 10.1021/acschembio.9b00845, 31944659
ACS chemical biology, 15, 2, 388-395, 10.1021/acschembio.9b00845, 31944659
Discovery of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions via Dynamic Combinatorial Chemistry
Publikation
Hartman A,
Elgaher W,
Hertrich N,
Andrei S,
Ottmann C,
Hirsch A
(2020)
ACS medicinal chemistry letters, 11, 5, 1041-1046, 10.1021/acsmedchemlett.9b00541, 32435423
ACS medicinal chemistry letters, 11, 5, 1041-1046, 10.1021/acsmedchemlett.9b00541, 32435423
Protein-Templated Dynamic Combinatorial Chemistry: Brief Overview and Experimental Protocol
Publikation
Hartman A,
Gierse R,
Hirsch A
(2019)
European journal of organic chemistry, 2019, 22, 3581-3590, 10.1002/ejoc.201900327, 31680778
European journal of organic chemistry, 2019, 22, 3581-3590, 10.1002/ejoc.201900327, 31680778
Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry
Publikation
Prismawan D,
van der Vlag R,
Guo H,
Dekker F,
Hirsch A
(2019)
HCA, 102, 5, 10.1002/hlca.201900040, 31231138
HCA, 102, 5, 10.1002/hlca.201900040, 31231138
Spray-drying of inhalable, multifunctional formulations for the treatment of biofilms formed in cystic fibrosis
Publikation
Lababidi N,
Ofosu Kissi E,
Elgaher W,
Sigal V,
Haupenthal J,
Schwarz B,
Hirsch A,
Rades T,
Schneider M
(2019)
Journal of Controlled Release, 314, 62-71, 10.1016/j.jconrel.2019.10.038
Journal of Controlled Release, 314, 62-71, 10.1016/j.jconrel.2019.10.038
Low-Dimensional Metal-Organic Coordination Structures on Graphene
Publikation
Li J,
Solianyk L,
Schmidt N,
Baker B,
Gottardi S,
Moreno Lopez J,
Enache M,
Monjas L,
van der Vlag R,
Havenith R,
Hirsch A,
Stöhr M
(2019)
The journal of physical chemistry. C, Nanomaterials and interfaces, 123, 20, 12730-12735, 10.1021/acs.jpcc.9b00326, 31156737
The journal of physical chemistry. C, Nanomaterials and interfaces, 123, 20, 12730-12735, 10.1021/acs.jpcc.9b00326, 31156737