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Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors
Publikation
Ropponen H,
Diamanti E,
Johannsen S,
Illarionov B,
Hamid R,
Jaki M,
Sass P,
Fischer M,
Haupenthal J,
Hirsch A
(2023)
ChemMedChem, 10.1002/cmdc.202300346, 37718320
ChemMedChem, 10.1002/cmdc.202300346, 37718320
Genotoxic and mutational potential of monocyclic terpenoids (carvacrol, carvone and thymol) in Drosophila melanogaster
Publikation
Nesterkina M,
Bilokon S,
Alieksieieva T,
Kravchenko I,
Hirsch A
(2023)
Toxicol. Rep., 10, 10.1016/j.toxrep.2023.02.009
Toxicol. Rep., 10, 10.1016/j.toxrep.2023.02.009
Selective Activation of TRPC6 Ion Channel by Metallated Type-B Polyprenylated Polycyclic Acylphloroglucinols
Publikation
Peslalz P,
Kraus F,
Izzo F,
Bleisch A,
El Hamdaoui Y,
Schulz I,
Kany A,
Hirsch A,
Friedland K,
Plietker B
(2023)
Manuscript, 10.26434/chemrxiv-2023-6w94r
Manuscript, 10.26434/chemrxiv-2023-6w94r
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle
Publikation
Hamed M,
Abdelsamie A,
Rox K,
Schütz C,
Kany A,
Röhrig T,
Schmelz S,
Blankenfeldt W,
Arce-Rodriguez A,
Borrero-de Acuña J,
Jahn D,
Rademacher J,
Ringshausen F,
Cramer N,
Tümmler B,
Hirsch A,
Hartmann R,
Empting M
(2023)
Adv. Sci., Online, 10.1002/advs.202204443
Adv. Sci., Online, 10.1002/advs.202204443
Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation
Publikation
Chan A,
Ho T,
Irfan R,
Hamid R,
Rudge E,
Iqbal A,
Turner A,
Hirsch A.,
Leeper F
(2023)
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602
Bioorganic chemistry, 138, 10.1016/j.bioorg.2023.106602
1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding
Publikation
Hamid R,
Adam S,
Lacour A,
Monjas L,
Köhnke J,
Hirsch A
(2023)
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
The Journal of biological chemistry, 10.1016/j.jbc.2023.105152, 37567475
A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum
Publikation
Bravo P,
Diamanti E,
Hamed M,
Bizzarri L,
Wiedemar N,
Passecker A,
Brancucci N,
Albisetti A,
Gumpp C,
Illarionov B,
Fischer M,
Witschel M,
Schehl T,
Hahne H,
Mäser P,
Rottmann M,
Hirsch A
(2025)
Angew. Chem. Int. Ed., 64, 10.1002/anie.202514085, 41116297
Angew. Chem. Int. Ed., 64, 10.1002/anie.202514085, 41116297
Development of Fragment-Based Inhibitors of the Bacterial Deacetylase LpxC with Low Nanomolar Activity
Publikation
Mielniczuk S,
Hoff K,
Baselious F,
Li Y,
Haupenthal J,
Kany A,
Riedner M,
Rohde H,
Rox K,
Hirsch A,
Krimm I,
Sippl W,
Holl R
(2024)
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295
Journal of medicinal chemistry, 67, 19, 17363-17391, 10.1021/acs.jmedchem.4c01262, 39303295
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity
Publikation
Al-Saad O,
Gabr M,
Darwish S,
Rullo M,
Pisani L,
Miniero D,
Liuzzi G,
Kany A,
Hirsch A,
Abadi A,
Engel M,
Catto M,
Abdel-Halim M
(2024)
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
European journal of medicinal chemistry, 10.1016/j.ejmech.2024.116266
Two natural compounds as potential inhibitors against the Helicobacter pylori and Acinetobacter baumannii IspD enzymes
Publikation
Chen X,
Zhao H,
Wang C,
Hamed M,
Shang Q,
Yang Y,
Diao X,
Sun X,
Hu W,
Jiang X,
Zhang Y,
Hirsch A,
Wu D,
Zhuang J
(2024)
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721
Int. J. Antimicrob. Agents, 63, 5, 10.1016/j.ijantimicag.2024.107160, 38537721